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Condition (MeSH)

Fractures, Ununited

ClinicalTrials.gov lists 69 trials for Fractures, Ununited or a narrower condition beneath it. Zimmer Biomet has the most among industry and government lead sponsors, with 7.

MeSH D005599 Wounds and Injuries C26
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Phase 1 Phase 1 2 Phase 1/2 Phase 1/2 6 Phase 2 Phase 2 6 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 3 Phase 4 Phase 4 2 Not applicable Not applicable 21 Observational Observational 28 Phase 1 Phase 1 2 Phase 1/2 Phase 1/2 6 Phase 2 Phase 2 6 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 3 Phase 4 Phase 4 2 Not applicable Not applicable 21 Observational Observational 28

Trials per phase (log scale)

42 of the 69 trials are tagged with Fractures, Ununited itself; the rest are tagged with a narrower condition beneath it.

Get the Fractures, Ununited report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Fractures, Ununited trials start? (22)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 7

1998: 1 trials (Observational 1) 2003: 1 trials (Phase 1/2 1) 2005: 1 trials (Observational 1) 2006: 1 trials (Observational 1) 2008: 1 trials (Phase 1/2 1) 2010: 2 trials (Observational 2) 2011: 5 trials (Observational 2, Not applicable 2, Phase 2 1) 2012: 5 trials (Observational 2, Not applicable 2, Phase 2 1) 2013: 3 trials (Observational 1, Phase 2 2) 2014: 6 trials (Not applicable 3, Phase 2 1, Phase 1/2 1, Phase 1 1) 2015: 3 trials (Not applicable 1, Phase 2/3 1, Phase 2 1) 2016: 2 trials (Observational 1, Not applicable 1) 2017: 4 trials (Observational 1, Phase 4 1, Phase 3 1, Phase 1/2 1) 2018: 1 trials (Phase 1/2 1) 2019: 7 trials (Observational 5, Not applicable 1, Phase 1/2 1) 2020: 7 trials (Observational 4, Not applicable 3) 2021: 3 trials (Observational 2, Not applicable 1) 2022: 5 trials (Not applicable 3, Phase 4 1, Phase 1 1) 2023: 4 trials (Observational 1, Not applicable 2, Phase 3 1) 2024: 2 trials (Observational 1, Not applicable 1) 2025: 3 trials (Observational 2, Phase 3 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 2
2025 3
2024 2
2023 4
2022 5
2021 3
2020 7
2019 7
2018 1
2017 4

No forecast is made for this condition: it averages 3.0 trial starts a year over the five years to September, under the 5 a year the method needs.

Prediction, not a registry value: median of 36 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 32 months across 37 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Fractures, Ununited trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 2
Phase 1/2 6
Phase 2 6
Phase 2/3 1
Phase 3 3
Phase 4 2
Not applicable 21
Observational 28

How many Fractures, Ununited trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 2
Recruiting 6
Enrolling by invitation 1
Active, not recruiting 6
Completed 23

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Fractures, Ununited trials? (4)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Zimmer Biomet 7
Novadip Biosciences 2
Baxano Surgical, Inc. 1
Bone Therapeutics S.A 1

Interventions as named in the registry (15)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Percutaneous injection 1
NVD-003, an autologous 3D scaffold free osteogenic graft 1
Transplantation of allogeneic MSCs in nonunion fracture 1
Stem Cells,Mesenchymal 1
[PRP] platelet rich plasma 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Fractures, Ununited trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
General SAE 38 1
Other- Spinal stenosis 5 1
Radiculitis 5 1
Other- Adjacent level disease 4 1
Intracranial hemorrhage 2 1

Which publications cover Fractures, Ununited? (235)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Treatment of scaphoid fractures and pseudarthroses with the human allogeneic cortical bone screw. A multicentric retrospective study. Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 2023 Yes
Vascularized versus non-vascularized bone grafting for scaphoid nonunion without avascular necrosis: a randomized clinical trial. The Journal of hand surgery, European volume 2023 Yes
Arthroscopic versus open cancellous bone grafting for scaphoid delayed/nonunion in adults (SCOPE-OUT): study protocol for a randomized clinical trial. Trials 2023 Yes
Arthroscopic Treatment of Scaphoid Nonunion With Olecranon Bone Graft and Screw Fixation Leads to Union and Improved Outcomes. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2022 Yes
Minimal Pain Decrease Between 2 and 4 Weeks After Nonoperative Management of a Displaced Midshaft Clavicle Fracture Is Associated with a High Risk of Symptomatic Nonunion. Clinical orthopaedics and related research 2021 Yes

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

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