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Condition (MeSH)

Hepatitis, Chronic

ClinicalTrials.gov lists 1,914 trials for Hepatitis, Chronic or a narrower condition beneath it. Hoffmann-La Roche has the most among industry and government lead sponsors, with 132.

MeSH D006521 Digestive System Diseases C06 C23
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Phase 1 Phase 1 211 Phase 1/2 Phase 1/2 66 Phase 2 Phase 2 362 Phase 2/3 Phase 2/3 28 Phase 3 Phase 3 276 Phase 4 Phase 4 346 Not applicable Not applicable 159 Observational Observational 461 Phase 1 Phase 1 211 Phase 1/2 Phase 1/2 66 Phase 2 Phase 2 362 Phase 2/3 Phase 2/3 28 Phase 3 Phase 3 276 Phase 4 Phase 4 346 Not applicable Not applicable 159 Observational Observational 461

Trials per phase

1 more section with rows

78 of the 1,914 trials are tagged with Hepatitis, Chronic itself; the rest are tagged with a narrower condition beneath it.

Get the Hepatitis, Chronic report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Hepatitis, Chronic trials start? (32)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 126

1992: 1 trials (Observational 1) 1995: 2 trials (Observational 1, Phase 2 1) 1997: 1 trials (Phase 3 1) 1998: 1 trials (Phase 2/3 1) 1999: 1 trials (Phase 4 1) 2000: 10 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 3 4, Phase 2 2) 2001: 16 trials (Observational 1, Phase 4 1, Phase 3 4, Phase 2/3 1, Phase 2 5, Phase 1/2 1, Phase 1 3) 2002: 30 trials (Observational 2, Not applicable 1, Phase 4 8, Phase 3 12, Phase 2 7) 2003: 37 trials (Observational 3, Not applicable 1, Phase 4 14, Phase 3 9, Phase 2 5, Phase 1/2 5) 2004: 43 trials (Observational 7, Not applicable 1, Phase 4 10, Phase 3 14, Phase 2 8, Phase 1/2 3) 2005: 85 trials (Observational 19, Not applicable 4, Phase 4 24, Phase 3 20, Phase 2 16, Phase 1 2) 2006: 68 trials (Observational 14, Not applicable 1, Phase 4 20, Phase 3 12, Phase 2/3 2, Phase 2 13, Phase 1/2 1, Phase 1 5) 2007: 90 trials (Observational 14, Not applicable 4, Phase 4 28, Phase 3 12, Phase 2/3 2, Phase 2 18, Phase 1/2 4, Phase 1 8) 2008: 82 trials (Observational 11, Not applicable 8, Phase 4 21, Phase 3 14, Phase 2 13, Phase 1/2 7, Phase 1 8) 2009: 84 trials (Observational 21, Not applicable 5, Phase 4 20, Phase 3 6, Phase 2 15, Phase 1/2 6, Phase 1 11) 2010: 65 trials (Observational 19, Not applicable 2, Phase 4 11, Phase 3 12, Phase 2/3 2, Phase 2 13, Phase 1 6) 2011: 119 trials (Observational 23, Not applicable 6, Phase 4 23, Phase 3 23, Phase 2 27, Phase 1/2 5, Phase 1 12) 2012: 126 trials (Observational 29, Not applicable 6, Phase 4 15, Phase 3 32, Phase 2/3 2, Phase 2 23, Phase 1/2 3, Phase 1 16) 2013: 93 trials (Observational 16, Not applicable 7, Phase 4 17, Phase 3 18, Phase 2/3 2, Phase 2 19, Phase 1/2 3, Phase 1 11) 2014: 79 trials (Observational 21, Not applicable 8, Phase 4 8, Phase 3 15, Phase 2/3 3, Phase 2 13, Phase 1/2 4, Phase 1 7) 2015: 109 trials (Observational 27, Not applicable 3, Phase 4 25, Phase 3 18, Phase 2/3 3, Phase 2 22, Phase 1/2 3, Phase 1 8) 2016: 108 trials (Observational 27, Not applicable 19, Phase 4 22, Phase 3 15, Phase 2/3 1, Phase 2 16, Phase 1 8) 2017: 84 trials (Observational 28, Not applicable 11, Phase 4 17, Phase 3 11, Phase 2/3 2, Phase 2 7, Phase 1/2 1, Phase 1 7) 2018: 72 trials (Observational 23, Not applicable 7, Phase 4 13, Phase 3 3, Phase 2/3 2, Phase 2 11, Phase 1/2 2, Phase 1 11) 2019: 74 trials (Observational 26, Not applicable 12, Phase 4 7, Phase 3 4, Phase 2/3 1, Phase 2 17, Phase 1/2 2, Phase 1 5) 2020: 71 trials (Observational 19, Not applicable 6, Phase 4 8, Phase 3 1, Phase 2 18, Phase 1/2 2, Phase 1 17) 2021: 61 trials (Observational 15, Not applicable 6, Phase 4 11, Phase 3 2, Phase 2 14, Phase 1/2 1, Phase 1 12) 2022: 71 trials (Observational 20, Not applicable 12, Phase 4 7, Phase 3 2, Phase 2 14, Phase 1/2 2, Phase 1 14) 2023: 58 trials (Observational 21, Not applicable 5, Phase 4 1, Phase 2 15, Phase 1/2 4, Phase 1 12) 2024: 67 trials (Observational 24, Not applicable 8, Phase 4 3, Phase 2/3 1, Phase 2 13, Phase 1/2 3, Phase 1 15) 2025: 42 trials (Observational 12, Not applicable 4, Phase 4 2, Phase 3 7, Phase 2/3 1, Phase 2 9, Phase 1/2 3, Phase 1 4)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 47
2025 42
2024 67
2023 58
2022 71
2021 61
2020 71
2019 74
2018 72
2017 84

Forecast of the full-year count, planned starts included, not rows of this table: about 59 trials starting in 2026 and about 52 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 35 months from start to primary completion across 82 trials still running at the 2026-10-09 snapshot; registered median of 25 months across 1,262 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Hepatitis, Chronic trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 211
Phase 1/2 66
Phase 2 362
Phase 2/3 28
Phase 3 276
Phase 4 346
Not applicable 159
Observational 461
Expanded access 5

How many Hepatitis, Chronic trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 48
Recruiting 101
Enrolling by invitation 5
Active, not recruiting 53
Completed 1,145

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Hepatitis, Chronic trials? (11)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Hoffmann-La Roche 132
Merck Sharp & Dohme LLC 110
AbbVie 72
Gilead Sciences 71
Bristol-Myers Squibb 42

Which drugs are being tested for Hepatitis, Chronic? (7)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
PEGinterferon alfa-2a 167
Entecavir 109
Peginterferon Alfa-2B 87
GS-7340 54
LAMIVUDINE 33

Interventions as named in the registry (8)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Ribavirine 337
tenofovir disproxil fumarate 82
PEGASYS [peginterferon alfa-2a] 47
Sofosbuvir, Sovaldi 40
telbivudine/LDT600 37

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Hepatitis, Chronic trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Anaemia 440 76
Pneumonia 258 82
Pyrexia 137 56
Depression 128 56
Hepatic neoplasm malignant 126 20

Which publications cover Hepatitis, Chronic? (69)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (4)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages