Condition (MeSH)
Herpes Labialis
ClinicalTrials.gov lists 52 trials for Herpes Labialis or a narrower condition beneath it.
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Trials per phase
52 of the 52 trials are tagged with Herpes Labialis itself; the rest are tagged with a narrower condition beneath it.
When did Herpes Labialis trials start? (21)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2023 | 1 |
| 2022 | 2 |
| 2021 | 1 |
| 2020 | 3 |
| 2018 | 2 |
| 2017 | 2 |
| 2016 | 3 |
| 2015 | 1 |
| 2014 | 2 |
| 2013 | 3 |
Showing 10 of 21 earlier years.
No forecast is made for this condition: it averages 0.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 52 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Herpes Labialis trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 5 |
| Phase 1/2 | 3 |
| Phase 2 | 16 |
| Phase 2/3 | 1 |
| Phase 3 | 13 |
| Phase 4 | 3 |
| Not applicable | 10 |
| Observational | 1 |
How many Herpes Labialis trials are recruiting? (4)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 1 |
| Completed | 42 |
| Terminated | 4 |
| Unknown status | 5 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Herpes Labialis trials? (13)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Medivir | 4 |
| NanoBio Corporation | 4 |
| GlaxoSmithKline | 3 |
| Squarex, LLC | 3 |
| Beech Tree Labs, Inc. | 2 |
Showing 5 of 13 sponsors.
Which drugs are being tested for Herpes Labialis? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| NB-001 | 3 |
| Famciclovir | 3 |
| Squaric Acid Dibutyl Ester | 2 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| ME-609 | 4 |
| BOR15001L7 | 2 |
| Acyclovir in ME-609 vehicle (5% acyclovir) | 2 |
| BTL TML HSV | 2 |
| Current formulation | 1 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Herpes Labialis trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Allergic reaction | 1 | 1 |
| Ankle fracture | 1 | 1 |
| Atrial Fibrillation | 1 | 1 |
| Bronchitis | 1 | 1 |
| Cholelithiasis | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Herpes Labialis? (29)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Low-dose Oral Thimerosal for the Treatment of Oral Herpes: Clinical Trial Results and Improved Outcome After Post-hoc Analysis. | Journal of evidence-based integrative medicine | 2022 | Yes |
| Treatment of herpes labialis by photodynamic therapy: Study protocol clinical trial (SPIRIT compliant). | Medicine | 2020 | Yes |
| Immune characteristics correlating with HSV-1 immune control and effect of squaric acid dibutyl ester on immune characteristics of subjects with frequent herpes labialis episodes. | Immunity, inflammation and disease | 2019 | Yes |
| Treatment of herpes simplex labialis in macule and vesicle phases with photodynamic therapy. Report of two cases. | Photodiagnosis and photodynamic therapy | 2015 | Yes |
| Early treatment of cold sores with topical ME-609 decreases the frequency of ulcerative lesions: a randomized, double-blind, placebo-controlled, patient-initiated clinical trial. | Journal of the American Academy of Dermatology | 2011 | Yes |
Showing 5 of 29 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.