Condition (MeSH)
Herpes Zoster
ClinicalTrials.gov lists 277 trials for Herpes Zoster or a narrower condition beneath it. GlaxoSmithKline has the most among industry and government lead sponsors, with 43.
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Trials per phase (log scale)
275 of the 277 trials are tagged with Herpes Zoster itself; the rest are tagged with a narrower condition beneath it.
When did Herpes Zoster trials start? (29)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 28
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 11 |
| 2025 | 28 |
| 2024 | 19 |
| 2023 | 19 |
| 2022 | 11 |
| 2021 | 7 |
| 2020 | 13 |
| 2019 | 11 |
| 2018 | 9 |
| 2017 | 8 |
Showing 10 of 29 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 16 trials starting in 2026 and about 23 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 41 trials still running at the 2026-10-09 snapshot; registered median of 16 months across 171 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Herpes Zoster trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 32 |
| Phase 1/2 | 11 |
| Phase 2 | 50 |
| Phase 2/3 | 3 |
| Phase 3 | 63 |
| Phase 4 | 28 |
| Not applicable | 50 |
| Observational | 40 |
How many Herpes Zoster trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 14 |
| Recruiting | 32 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 18 |
| Completed | 175 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Herpes Zoster trials? (9)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| GlaxoSmithKline | 43 |
| Merck Sharp & Dohme LLC | 26 |
| NeurogesX | 9 |
| National Institute of Allergy and Infectious Diseases (NIAID) | 6 |
| MAXVAX Biotechnology Limited Liability Company | 5 |
Showing 5 of 9 sponsors.
Which drugs are being tested for Herpes Zoster? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| VARIVAX | 29 |
| Famciclovir | 4 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Shingrix vaccine | 41 |
| Valacyclovir arrow | 16 |
| Recombinant Zoster Vaccine | 9 |
| V212 | 6 |
| data collection | 5 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Herpes Zoster trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Pneumonia | 1,061 | 35 |
| Plasma cell myeloma | 412 | 11 |
| Cardiac failure | 396 | 20 |
| Atrial fibrillation | 387 | 27 |
| Myocardial infarction | 366 | 26 |
Showing 5 of 10 adverse events.
Which publications cover Herpes Zoster? (324)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Immune response and safety of the adjuvanted recombinant zoster vaccine in adults 50 years of age and older in India: A randomized phase 3 trial. | Vaccine | 2025 | Yes |
| Considering recombinant herpes zoster vaccine for fragile pediatric patients: A new opportunity. | Vaccine | 2025 | Yes |
| Herpes zoster recurrence, and safety and immunogenicity of the recombinant zoster vaccine in adults aged ≥50 years with a history of herpes zoster: A phase 3, randomized controlled trial. | The Journal of infection | 2025 | Yes |
| Immunogenicity of adjuvanted recombinant zoster vaccine in patients with rheumatoid arthritis treated with upadacitinib: 60-week results from a randomised controlled trial substudy. | RMD open | 2025 | Yes |
| Immunogenicity and Safety of Recombinant Herpes Zoster Vaccine in Patients With Inflammatory Bowel Disease on Vedolizumab or Anti-Tumor Necrosis Factor Therapy. | Clinical and translational gastroenterology | 2025 | Yes |
Showing 5 of 324 publications.
Sub-conditions in MeSH (2)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.