Condition (MeSH)
Hypercapnia
ClinicalTrials.gov lists 149 trials for Hypercapnia or a narrower condition beneath it.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
149 of the 149 trials are tagged with Hypercapnia itself; the rest are tagged with a narrower condition beneath it.
When did Hypercapnia trials start? (27)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 14
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 6 |
| 2025 | 7 |
| 2024 | 10 |
| 2023 | 11 |
| 2022 | 13 |
| 2021 | 9 |
| 2020 | 6 |
| 2019 | 6 |
| 2018 | 9 |
| 2017 | 3 |
Showing 10 of 27 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 7 trials starting in 2026 and about 8 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 32 months from start to primary completion across 12 trials still running at the 2026-10-09 snapshot; registered median of 15 months across 99 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Hypercapnia trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 5 |
| Phase 2/3 | 1 |
| Phase 3 | 7 |
| Phase 4 | 6 |
| Not applicable | 90 |
| Observational | 31 |
How many Hypercapnia trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 7 |
| Recruiting | 13 |
| Enrolling by invitation | 1 |
| Completed | 83 |
| Suspended | 1 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Hypercapnia trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Food and Drug Administration (FDA) | 2 |
| National Institutes of Health Clinical Center (CC) | 2 |
| ResMed | 2 |
Which drugs are being tested for Hypercapnia? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| SILDENAFIL | 3 |
Interventions as named in the registry (14)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| NORMOCAPNIA | 3 |
| citrate of caffeine | 2 |
| Cebranopadol 800 µg | 1 |
| Cebranopadol 600 µg | 1 |
| IMT | 1 |
Showing 5 of 14 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Hypercapnia trials report? (2)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| bleeding | 13 | 1 |
| Severe IVH or PVL | 3 | 1 |
Which publications cover Hypercapnia? (412)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Right Ventricular Response to Hypercapnia After Mitral Valve Repair: A Hemodynamic Assessment. | Acta anaesthesiologica Scandinavica | 2025 | Yes |
| Late Permissive Hypercapnia for Mechanically Ventilated Preterm Infants: A Randomized Trial. | Pediatric pulmonology | 2025 | Yes |
| The cost-effectiveness of mild hypercapnia after out-of-hospital cardiac arrest: a health economic evaluation alongside the TAME study. | Resuscitation | 2025 | Yes |
| Optimizing nonintubated laryngeal microsurgery: The effectiveness and safety of superior laryngeal nerve block with high-flow nasal oxygen-A prospective cohort study. | Journal of the Chinese Medical Association : JCMA | 2024 | Yes |
| Defining a phenotype of severe COPD patients who develop chronic hypercapnia. | Respiratory medicine | 2024 | Yes |
Showing 5 of 412 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.