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Condition (MeSH)

Signs and Symptoms, Respiratory

ClinicalTrials.gov lists 3,777 trials for Signs and Symptoms, Respiratory or a narrower condition beneath it.

MeSH D012818 Pathological Conditions, Signs and Symptoms C23
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Phase 1 Phase 1 159 Phase 1/2 Phase 1/2 83 Phase 2 Phase 2 243 Phase 2/3 Phase 2/3 31 Phase 3 Phase 3 186 Phase 4 Phase 4 206 Not applicable Not applicable 1,806 Observational Observational 1,060 Phase 1 Phase 1 159 Phase 1/2 Phase 1/2 83 Phase 2 Phase 2 243 Phase 2/3 Phase 2/3 31 Phase 3 Phase 3 186 Phase 4 Phase 4 206 Not applicable Not applicable 1,806 Observational Observational 1,060

Trials per phase (log scale)

2 more sections with rows

63 of the 3,777 trials are tagged with Signs and Symptoms, Respiratory itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Signs and Symptoms, Respiratory trials start? (33)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 14 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Unknown)

Top of scale: 283

1992: 1 trials (Not applicable 1) 1994: 1 trials (Observational 1) 1995: 1 trials (Observational 1) 1996: 1 trials (Phase 3 1) 1997: 2 trials (Not applicable 1, Phase 3 1) 1999: 8 trials (Observational 1, Not applicable 2, Phase 4 1, Phase 3 2, Phase 2 2) 2000: 6 trials (Observational 2, Not applicable 1, Phase 4 2, Phase 3 1) 2001: 12 trials (Observational 4, Not applicable 3, Phase 3 1, Phase 2/3 1, Phase 2 3) 2002: 20 trials (Observational 4, Not applicable 6, Phase 3 4, Phase 2/3 1, Phase 2 3, Phase 1/2 2) 2003: 20 trials (Observational 2, Not applicable 5, Phase 4 3, Phase 3 2, Phase 2/3 1, Phase 2 3, Phase 1/2 4) 2004: 38 trials (Observational 6, Not applicable 12, Phase 4 7, Phase 3 6, Phase 2/3 1, Phase 2 1, Phase 1/2 1, Phase 1 4) 2005: 44 trials (Observational 9, Not applicable 18, Phase 4 6, Phase 3 4, Phase 2 5, Phase 1/2 1, Phase 1 1) 2006: 63 trials (Observational 21, Not applicable 12, Phase 4 7, Phase 3 8, Phase 2 8, Phase 1/2 1, Phase 1 6) 2007: 64 trials (Observational 22, Not applicable 16, Phase 4 9, Phase 3 6, Phase 2 6, Phase 1/2 2, Phase 1 3) 2008: 73 trials (Observational 15, Not applicable 33, Phase 4 8, Phase 3 2, Phase 2/3 2, Phase 2 6, Phase 1/2 2, Phase 1 5) 2009: 89 trials (Observational 29, Not applicable 30, Phase 4 9, Phase 3 7, Phase 2 9, Phase 1/2 3, Phase 1 2) 2010: 116 trials (Observational 33, Not applicable 43, Phase 4 9, Phase 3 11, Phase 2 13, Phase 1/2 3, Phase 1 4) 2011: 136 trials (Observational 34, Not applicable 50, Phase 4 9, Phase 3 14, Phase 2/3 2, Phase 2 10, Phase 1/2 5, Phase 1 12) 2012: 132 trials (Observational 38, Not applicable 55, Phase 4 10, Phase 3 8, Phase 2/3 1, Phase 2 8, Phase 1/2 6, Phase 1 6) 2013: 148 trials (Observational 33, Not applicable 66, Phase 4 13, Phase 3 7, Phase 2 11, Phase 1/2 7, Phase 1 11) 2014: 130 trials (Observational 37, Not applicable 54, Phase 4 7, Phase 3 5, Phase 2/3 2, Phase 2 9, Phase 1/2 8, Phase 1 8) 2015: 148 trials (Observational 38, Not applicable 68, Phase 4 7, Phase 3 5, Phase 2/3 3, Phase 2 19, Phase 1/2 3, Phase 1 5) 2016: 186 trials (Observational 57, Not applicable 89, Phase 4 16, Phase 3 7, Phase 2/3 2, Phase 2 5, Phase 1/2 1, Phase 1 9) 2017: 170 trials (Observational 47, Not applicable 88, Phase 4 6, Phase 3 8, Phase 2/3 2, Phase 2 10, Phase 1/2 2, Phase 1 7) 2018: 207 trials (Other 1, Observational 61, Not applicable 106, Phase 4 7, Phase 3 7, Phase 2 10, Phase 1/2 5, Phase 1 10) 2019: 182 trials (Observational 43, Not applicable 107, Phase 4 7, Phase 3 7, Phase 2 13, Phase 1/2 1, Phase 1 4) 2020: 238 trials (Observational 75, Not applicable 104, Phase 4 5, Phase 3 16, Phase 2/3 2, Phase 2 18, Phase 1/2 5, Phase 1 13) 2021: 230 trials (Observational 63, Not applicable 131, Phase 4 8, Phase 3 10, Phase 2/3 4, Phase 2 5, Phase 1/2 4, Phase 1 5) 2022: 242 trials (Observational 65, Not applicable 134, Phase 4 10, Phase 3 9, Phase 2 12, Phase 1/2 2, Phase 1 10) 2023: 283 trials (Observational 85, Not applicable 157, Phase 4 9, Phase 3 6, Phase 2/3 1, Phase 2 12, Phase 1/2 5, Phase 1 8) 2024: 267 trials (Observational 86, Not applicable 138, Phase 4 9, Phase 3 4, Phase 2/3 3, Phase 2 12, Phase 1/2 4, Phase 1 11) 2025: 243 trials (Observational 78, Not applicable 125, Phase 4 4, Phase 3 11, Phase 2/3 2, Phase 2 13, Phase 1/2 3, Phase 1 7)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 246
2025 243
2024 267
2023 283
2022 242
2021 230
2020 238
2019 182
2018 207
2017 170

Forecast of the full-year count, planned starts included, not rows of this table: about 280 trials starting in 2026 and about 260 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 35 months from start to primary completion across 268 trials still running at the 2026-10-09 snapshot; registered median of 15 months across 2,328 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Signs and Symptoms, Respiratory trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 159
Phase 1/2 83
Phase 2 243
Phase 2/3 31
Phase 3 186
Phase 4 206
Not applicable 1,806
Observational 1,060
Expanded access 2
Unknown 1

How many Signs and Symptoms, Respiratory trials are recruiting? (11)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 211
Recruiting 395
Enrolling by invitation 27
Active, not recruiting 101
Available 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Signs and Symptoms, Respiratory? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Gefapixant 16
Montelukast 15
PROPOFOL 13
DEXMEDETOMIDINE 11

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Medicinal gas - oxygen (Nippon Gases 200 bar) 36
citrate of caffeine 23
Hypoxia 20
Dexamethasone/Dexamethasone acetate 19
Acetazolamide Pill 14

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Signs and Symptoms, Respiratory trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Asthma 104 8
Pneumonia 71 26
Other 60 3
Respiratory failure 44 10
Cardiac arrest 40 5

Sub-conditions in MeSH (20)

MeSH descendants one level down with at least one trial, most trials first.

+10 more sub-conditions

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, publications, prevalence, and rare-disease identity.

Browse all condition evidence pages