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Condition (MeSH)

Hypersensitivity, Delayed

ClinicalTrials.gov lists 393 trials for Hypersensitivity, Delayed or a narrower condition beneath it. National Heart, Lung, and Blood Institute (NHLBI) has the most among industry and government lead sponsors, with 8.

MeSH D006968 Immune System Diseases C20
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Phase 1 Phase 1 20 Phase 1/2 Phase 1/2 16 Phase 2 Phase 2 45 Phase 2/3 Phase 2/3 14 Phase 3 Phase 3 18 Phase 4 Phase 4 29 Not applicable Not applicable 109 Observational Observational 141 Phase 1 Phase 1 20 Phase 1/2 Phase 1/2 16 Phase 2 Phase 2 45 Phase 2/3 Phase 2/3 14 Phase 3 Phase 3 18 Phase 4 Phase 4 29 Not applicable Not applicable 109 Observational Observational 141

Trials per phase

1 more section with rows

15 of the 393 trials are tagged with Hypersensitivity, Delayed itself; the rest are tagged with a narrower condition beneath it.

Get the Hypersensitivity, Delayed report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Hypersensitivity, Delayed trials start? (32)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access)

Top of scale: 30

1991: 1 trials (Observational 1) 1995: 1 trials (Observational 1) 1996: 2 trials (Observational 2) 1998: 1 trials (Observational 1) 1999: 2 trials (Observational 1, Phase 2 1) 2000: 1 trials (Observational 1) 2001: 1 trials (Phase 3 1) 2002: 1 trials (Observational 1) 2003: 4 trials (Phase 3 2, Phase 1/2 1, Phase 1 1) 2004: 5 trials (Observational 3, Not applicable 1, Phase 4 1) 2005: 8 trials (Observational 4, Phase 3 1, Phase 2/3 1, Phase 2 2) 2006: 13 trials (Observational 5, Not applicable 2, Phase 4 2, Phase 2 4) 2007: 7 trials (Observational 4, Not applicable 1, Phase 4 1, Phase 2/3 1) 2008: 18 trials (Observational 5, Not applicable 4, Phase 4 2, Phase 2/3 3, Phase 2 3, Phase 1 1) 2009: 15 trials (Observational 4, Not applicable 3, Phase 3 2, Phase 2 6) 2010: 8 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 1/2 3, Phase 1 1) 2011: 10 trials (Observational 5, Not applicable 3, Phase 1/2 1, Phase 1 1) 2012: 14 trials (Observational 5, Not applicable 4, Phase 4 2, Phase 3 2, Phase 1/2 1) 2013: 17 trials (Observational 2, Not applicable 9, Phase 4 1, Phase 3 2, Phase 2 1, Phase 1 2) 2014: 21 trials (Other 1, Observational 6, Not applicable 5, Phase 4 2, Phase 2/3 1, Phase 2 4, Phase 1/2 1, Phase 1 1) 2015: 19 trials (Observational 6, Not applicable 8, Phase 4 2, Phase 2/3 2, Phase 1/2 1) 2016: 20 trials (Observational 4, Not applicable 11, Phase 4 1, Phase 2/3 2, Phase 2 1, Phase 1/2 1) 2017: 15 trials (Observational 8, Not applicable 4, Phase 4 2, Phase 1 1) 2018: 20 trials (Observational 8, Not applicable 10, Phase 4 1, Phase 1 1) 2019: 30 trials (Observational 14, Not applicable 5, Phase 4 2, Phase 3 2, Phase 2 4, Phase 1/2 1, Phase 1 2) 2020: 14 trials (Observational 4, Not applicable 6, Phase 4 1, Phase 2 2, Phase 1 1) 2021: 21 trials (Observational 12, Not applicable 5, Phase 2 2, Phase 1 2) 2022: 24 trials (Observational 6, Not applicable 8, Phase 4 1, Phase 3 3, Phase 2/3 2, Phase 2 3, Phase 1/2 1) 2023: 16 trials (Observational 5, Not applicable 4, Phase 4 1, Phase 3 3, Phase 2 1, Phase 1/2 1, Phase 1 1) 2024: 22 trials (Observational 10, Not applicable 5, Phase 4 3, Phase 2 2, Phase 1/2 2) 2025: 14 trials (Observational 4, Not applicable 5, Phase 2/3 1, Phase 2 3, Phase 1/2 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 17
2025 14
2024 22
2023 16
2022 24
2021 21
2020 14
2019 30
2018 20
2017 15

Forecast of the full-year count, planned starts included, not rows of this table: about 17 trials starting in 2026 and about 16 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored. The 2026 forecast is below the 17 already registered with a 2026 start date: at the cutoff, 4 trials were already registered to start in October to December, more than the method's monthly average allows for, and the method does not use those planned starts.

Prediction, not a registry value: median of 36 months from start to primary completion across 23 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 209 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Hypersensitivity, Delayed trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 20
Phase 1/2 16
Phase 2 45
Phase 2/3 14
Phase 3 18
Phase 4 29
Not applicable 109
Observational 141
Expanded access 1

How many Hypersensitivity, Delayed trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 19
Recruiting 41
Enrolling by invitation 5
Active, not recruiting 11
Available 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Hypersensitivity, Delayed trials? (4)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Heart, Lung, and Blood Institute (NHLBI) 8
National Institute of Allergy and Infectious Diseases (NIAID) 5
National Eye Institute (NEI) 4
Allerderm 3

Which drugs are being tested for Hypersensitivity, Delayed? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Prednisone 8
INFLIXIMAB 4

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Adalimumab-US 6
Acthar low dose (40 U) 5
BLOOD SAMPLE 3
Bronchoalveolar lavage 3
gp160 Vaccine (Immuno-AG) 2

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Hypersensitivity, Delayed trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 19 6
Acute respiratory failure 5 3
Atrial fibrillation 5 3
Hypoxia 5 2
Influenza 5 4

Which publications cover Hypersensitivity, Delayed? (190)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Regional differences in cell-mediated immunity in people with diabetic peripheral neuropathy. Diabetic medicine : a journal of the British Diabetic Association 2020 Yes
The Impact of Baked Egg and Baked Milk Diets on IgE- and Non-IgE-Mediated Allergy. Clinical reviews in allergy & immunology 2018 Yes
Practical Management of Antibiotic Hypersensitivity in 2017. The journal of allergy and clinical immunology. In practice 2017 Yes
Oral Challenge without Skin Testing Safely Excludes Clinically Significant Delayed-Onset Penicillin Hypersensitivity. The journal of allergy and clinical immunology. In practice 2017 Yes
Frequent occurrence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments. The Journal of allergy and clinical immunology 2016 Yes

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages