Condition (MeSH)
Hypobetalipoproteinemias
ClinicalTrials.gov lists 11 trials for Hypobetalipoproteinemias or a narrower condition beneath it. National Heart, Lung, and Blood Institute (NHLBI) has the most among industry and government lead sponsors, with 2.
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Trials per phase
7 of the 11 trials are tagged with Hypobetalipoproteinemias itself; the rest are tagged with a narrower condition beneath it.
When did Hypobetalipoproteinemias trials start? (9)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 2
- Phase 3
- Not applicable
- Observational
Top of scale: 2
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2022 | 2 |
| 2018 | 2 |
| 2016 | 1 |
| 2015 | 1 |
| 2014 | 1 |
| 2011 | 1 |
| 2006 | 1 |
| 2000 | 1 |
| 1997 | 1 |
No forecast is made for this condition: it averages 0.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 11 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Hypobetalipoproteinemias trials in? (4)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 2 | 1 |
| Phase 3 | 2 |
| Not applicable | 3 |
| Observational | 5 |
How many Hypobetalipoproteinemias trials are recruiting? (4)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 1 |
| Active, not recruiting | 1 |
| Completed | 8 |
| Unknown status | 1 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Hypobetalipoproteinemias trials? (2)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | 2 |
| Kastle Therapeutics, LLC | 1 |
Which drugs are being tested for Hypobetalipoproteinemias? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Cosyntropin | 1 |
| Mipomersen | 1 |
| Tocofersolan | 1 |
Interventions as named in the registry (3)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Tocofersolan and tocopherol alpha | 1 |
| tocopherol alpha | 1 |
| Characterization of carotenoid status and plasma levels of oxidative stress markers in patients (case group only) | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Hypobetalipoproteinemias trials report? (3)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Liver-related death | 24 | 1 |
| Nasal septum disorder | 1 | 1 |
| Non-liver-related death | 1 | 1 |
Which publications cover Hypobetalipoproteinemias? (10)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease. | Journal of lipid research | 2018 | Yes |
| Clinical and biochemical characteristics of individuals with low cholesterol syndromes: A comparison between familial hypobetalipoproteinemia and familial combined hypolipidemia. | Journal of clinical lipidology | 2017 | Yes |
| A randomized controlled trial to evaluate the effectiveness of CouPLES: a spouse-assisted lifestyle change intervention to improve low-density lipoprotein cholesterol. | Preventive medicine | 2013 | Yes |
| Familial hypobetalipoproteinemia: a review. | Journal of lipid research | 2003 | Yes |
| Hepatitis C virus-associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis, and liver fibrosis. | The American journal of gastroenterology | 2003 | Yes |
Showing 5 of 10 publications.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Hypobetalipoproteinemia | 31154 | Exact | Orphadata Science knowledge files, Product 1 |
| Hypobetalipoproteinemia | 31154 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence.