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Condition (MeSH)

Intervertebral Disc Displacement

ClinicalTrials.gov lists 430 trials for Intervertebral Disc Displacement or a narrower condition beneath it. Intrinsic Therapeutics has the most among industry and government lead sponsors, with 8.

MeSH D007405 Musculoskeletal Diseases C05 C23
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Phase 1 Phase 1 6 Phase 1/2 Phase 1/2 5 Phase 2 Phase 2 6 Phase 2/3 Phase 2/3 3 Phase 3 Phase 3 19 Phase 4 Phase 4 32 Not applicable Not applicable 252 Observational Observational 107 Phase 1 Phase 1 6 Phase 1/2 Phase 1/2 5 Phase 2 Phase 2 6 Phase 2/3 Phase 2/3 3 Phase 3 Phase 3 19 Phase 4 Phase 4 32 Not applicable Not applicable 252 Observational Observational 107

Trials per phase (log scale)

430 of the 430 trials are tagged with Intervertebral Disc Displacement itself; the rest are tagged with a narrower condition beneath it.

Get the Intervertebral Disc Displacement report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Intervertebral Disc Displacement trials start? (28)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 45

1996: 1 trials (Phase 3 1) 2000: 4 trials (Phase 4 3, Phase 2 1) 2001: 1 trials (Phase 3 1) 2002: 3 trials (Not applicable 2, Phase 2 1) 2003: 3 trials (Not applicable 1, Phase 2 1, Phase 1 1) 2004: 3 trials (Observational 1, Phase 4 1, Phase 3 1) 2005: 1 trials (Phase 4 1) 2006: 7 trials (Observational 1, Not applicable 5, Phase 2/3 1) 2007: 7 trials (Observational 1, Not applicable 3, Phase 4 1, Phase 3 1, Phase 1 1) 2008: 5 trials (Observational 1, Not applicable 2, Phase 3 1, Phase 2 1) 2009: 13 trials (Observational 3, Not applicable 4, Phase 4 2, Phase 3 2, Phase 2/3 1, Phase 2 1) 2010: 7 trials (Observational 2, Not applicable 2, Phase 4 2, Phase 3 1) 2011: 13 trials (Observational 2, Not applicable 4, Phase 4 2, Phase 3 3, Phase 1 2) 2012: 8 trials (Observational 3, Not applicable 4, Phase 1/2 1) 2013: 10 trials (Observational 2, Not applicable 6, Phase 4 1, Phase 1/2 1) 2014: 12 trials (Observational 1, Not applicable 8, Phase 4 1, Phase 3 1, Phase 2/3 1) 2015: 10 trials (Observational 1, Not applicable 5, Phase 4 2, Phase 3 1, Phase 1/2 1) 2016: 15 trials (Observational 2, Not applicable 12, Phase 4 1) 2017: 13 trials (Observational 4, Not applicable 8, Phase 3 1) 2018: 26 trials (Observational 8, Not applicable 12, Phase 4 4, Phase 3 2) 2019: 24 trials (Observational 7, Not applicable 14, Phase 4 3) 2020: 24 trials (Observational 11, Not applicable 9, Phase 4 1, Phase 3 2, Phase 2 1) 2021: 30 trials (Observational 7, Not applicable 23) 2022: 45 trials (Observational 11, Not applicable 28, Phase 4 4, Phase 3 1, Phase 1 1) 2023: 42 trials (Observational 11, Not applicable 28, Phase 4 1, Phase 1/2 1, Phase 1 1) 2024: 37 trials (Observational 13, Not applicable 24) 2025: 33 trials (Observational 6, Not applicable 26, Phase 1/2 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 32
2025 33
2024 37
2023 42
2022 45
2021 30
2020 24
2019 24
2018 26
2017 13

Forecast of the full-year count, planned starts included, not rows of this table: about 41 trials starting in 2026 and about 36 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 33 months from start to primary completion across 23 trials still running at the 2026-10-09 snapshot; registered median of 15 months across 245 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Intervertebral Disc Displacement trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 6
Phase 1/2 5
Phase 2 6
Phase 2/3 3
Phase 3 19
Phase 4 32
Not applicable 252
Observational 107

How many Intervertebral Disc Displacement trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 33
Recruiting 42
Enrolling by invitation 10
Active, not recruiting 11
Completed 216

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Intervertebral Disc Displacement trials? (1)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Intrinsic Therapeutics 8

Which drugs are being tested for Intervertebral Disc Displacement? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Pregabalin 4
+/- Bupivacaine HCl 3

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Transforaminal epidural steroid injection 10
Acupuncture 8
Herbal medicine 6
Control (placebo) group 5
Erector Spinae Plane Block 5

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Intervertebral Disc Displacement trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Revision Surgery for Malposition/Loosening 15 1
Appendicitis 3 2
Surgery - Index Level 3 1
Dysphagia 2 1
Fracture injury after fall 2 1

Which publications cover Intervertebral Disc Displacement? (697)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Incidence of and risk factors for lumbar disc herniation with radiculopathy in adults: a systematic review. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2025 Yes
A new hernia blocking system to prevent recurrent lumbar disc herniation: surgical technique, intraoperative findings and six-months post-operative outcomes. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2025 Yes
Impact of Spinal Manipulative Therapy on Brain Function and Pain Alleviation in Lumbar Disc Herniation: A Resting-State fMRI Study. Chinese journal of integrative medicine 2025 Yes
Impact of Condoliase on Health-related Quality of Life in Participants With Radicular Leg Pain Associated With Lumbar Disk Herniation: Results From a United States Phase 3 Clinical Trial. Spine 2025 Yes
Surgical versus Nonsurgical Treatment for Cervical Radiculopathy. NEJM evidence 2025 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

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