Condition (MeSH)
Lecithin Cholesterol Acyltransferase Deficiency
ClinicalTrials.gov lists 62 trials for Lecithin Cholesterol Acyltransferase Deficiency or a narrower condition beneath it. IPCA Laboratories Ltd. has the most among industry and government lead sponsors, with 12.
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Trials per phase (log scale)
62 of the 62 trials are tagged with Lecithin Cholesterol Acyltransferase Deficiency itself; the rest are tagged with a narrower condition beneath it.
When did Lecithin Cholesterol Acyltransferase Deficiency trials start? (21)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 14
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 1 |
| 2023 | 3 |
| 2022 | 3 |
| 2018 | 2 |
| 2017 | 3 |
| 2016 | 1 |
| 2014 | 3 |
| 2013 | 4 |
| 2012 | 14 |
Showing 10 of 21 earlier years.
No forecast is made for this condition: it averages 1.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Lecithin Cholesterol Acyltransferase Deficiency trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 52 |
| Phase 2 | 1 |
| Phase 3 | 1 |
| Phase 4 | 1 |
| Not applicable | 4 |
| Observational | 3 |
How many Lecithin Cholesterol Acyltransferase Deficiency trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 2 |
| Completed | 55 |
| Terminated | 2 |
| Withdrawn | 1 |
| Unknown status | 2 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Lecithin Cholesterol Acyltransferase Deficiency trials? (12)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| IPCA Laboratories Ltd. | 12 |
| Par Pharmaceutical, Inc. | 11 |
| Dr. Reddy's Laboratories Limited | 7 |
| Pfizer | 4 |
| Actavis Inc. | 2 |
Showing 5 of 12 sponsors.
Which drugs are being tested for Lecithin Cholesterol Acyltransferase Deficiency? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Lisinopril | 2 |
Interventions as named in the registry (14)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| PO Morphine | 2 |
| IM olanzapine | 2 |
| Ultracet | 2 |
| 1% Metformin | 2 |
| Ondansetron - Parts A + B | 2 |
Showing 5 of 14 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Lecithin Cholesterol Acyltransferase Deficiency trials report? (2)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Liver-related death | 24 | 1 |
| Non-liver-related death | 1 | 1 |
Which publications cover Lecithin Cholesterol Acyltransferase Deficiency? (3)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| A systematic review of the natural history and biomarkers of primary lecithin:cholesterol acyltransferase deficiency. | Journal of lipid research | 2022 | Yes |
| Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice. | Journal of lipid research | 2007 | Yes |
| Thrombin binding and response in platelets from patients with dyslipoproteinemias: increased stimulus-response coupling in type II hyperlipoproteinemia. | Blood | 1986 | No |
Prevalence (4)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| LCAT deficiency | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Exact |
| LCAT deficiency | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Exact |
| LCAT deficiency | Cases families | Worldwide | Not stated | Exact | |
| LCAT deficiency | Cases families | Worldwide | Not stated | Exact |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| LCAT deficiency | 650 | Exact | Orphadata Science knowledge files, Product 1 |
| LCAT deficiency | 650 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.