Condition (MeSH)
Legg-Calve-Perthes Disease
ClinicalTrials.gov lists 25 trials for Legg-Calve-Perthes Disease or a narrower condition beneath it.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase
25 of the 25 trials are tagged with Legg-Calve-Perthes Disease itself; the rest are tagged with a narrower condition beneath it.
When did Legg-Calve-Perthes Disease trials start? (15)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 5 |
| 2024 | 1 |
| 2023 | 2 |
| 2018 | 1 |
| 2017 | 1 |
| 2015 | 2 |
| 2013 | 2 |
| 2012 | 2 |
| 2011 | 1 |
Showing 10 of 15 earlier years.
No forecast is made for this condition: it averages 2.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 4 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Legg-Calve-Perthes Disease trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 2 |
| Phase 1/2 | 1 |
| Phase 2 | 3 |
| Phase 3 | 2 |
| Not applicable | 7 |
| Observational | 10 |
How many Legg-Calve-Perthes Disease trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 4 |
| Enrolling by invitation | 3 |
| Active, not recruiting | 3 |
| Completed | 9 |
| Terminated | 4 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Legg-Calve-Perthes Disease trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd. | 2 |
| Zimmer Biomet | 2 |
| Assaf-Harofeh Medical Center | 1 |
| Bone Therapeutics S.A | 1 |
| DePuy International | 1 |
Interventions as named in the registry (15)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Alendronate 20 mg | 2 |
| 15 ml Bupivacaine Hcl 0.25% injection | 1 |
| RAB001 high dose | 1 |
| Hyperbaric Oxygen | 1 |
| RAB001 low dose | 1 |
Showing 5 of 15 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Legg-Calve-Perthes Disease trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| disease progression | 21 | 1 |
| Chest pain | 2 | 1 |
| Colitis ulcerative | 2 | 1 |
| Fall | 2 | 1 |
| Acute renal kidney | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Legg-Calve-Perthes Disease? (10)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Natural History of Structural Hip Abnormalities and the Potential for Hip Preservation. | The Journal of the American Academy of Orthopaedic Surgeons | 2018 | Yes |
| Lateral shelf acetabuloplasty for severe Legg-Calvé-Perthes disease in patients older than 8 years: A mean eleven-year follow-up. | Medicine | 2016 | Yes |
| Legg-Calvé-Perthes disease: an overview with recent literature. | Bulletin of the Hospital for Joint Disease (2013) | 2014 | Yes |
| Joint-preserving surgery improves pain, range of motion, and abductor strength after Legg-Calvé-Perthes disease. | Clinical orthopaedics and related research | 2012 | Yes |
| The classic: Treatment of malum coxae senilis, old slipped upper femoral epiphysis, intrapelvic protrusion of the acetabulum, and coxa plana by means of acetabuloplasty. 1936. | Clinical orthopaedics and related research | 2009 | Yes |
Showing 5 of 10 publications.
Prevalence (6)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Legg-Calvé-Perthes disease | Annual incidence | 1-9 / 100 000 | Worldwide | Not stated | Exact |
| Legg-Calvé-Perthes disease | Annual incidence | 1-9 / 100 000 | Worldwide | Not stated | Unspecified |
| Legg-Calvé-Perthes disease | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| Legg-Calvé-Perthes disease | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| Legg-Calvé-Perthes disease | Annual incidence | 1-9 / 100 000 | Worldwide | Not stated | Exact |
Showing 5 of 6 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Legg-Calvé-Perthes disease | 2380 | Exact | Orphadata Science knowledge files, Product 1 |
| Legg-Calvé-Perthes disease | 2380 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.