Skip to content
Pharma Observatory a Scientist.com platform

Condition (MeSH)

Femur Head Necrosis

ClinicalTrials.gov lists 84 trials for Femur Head Necrosis or a narrower condition beneath it. Aesculap AG has the most among industry and government lead sponsors, with 6.

MeSH D005271 Musculoskeletal Diseases C05 C23 Listed by Orphanet as a rare disease
Email me this page as a PDF

Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Phase 1 Phase 1 3 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 6 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 5 Phase 4 Phase 4 5 Not applicable Not applicable 25 Observational Observational 37 Phase 1 Phase 1 3 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 6 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 5 Phase 4 Phase 4 5 Not applicable Not applicable 25 Observational Observational 37

Trials per phase (log scale)

64 of the 84 trials are tagged with Femur Head Necrosis itself; the rest are tagged with a narrower condition beneath it.

Get the Femur Head Necrosis report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Femur Head Necrosis trials start? (25)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 11

2000: 2 trials (Phase 4 1, Phase 3 1) 2001: 3 trials (Observational 1, Phase 4 1, Phase 3 1) 2002: 1 trials (Observational 1) 2003: 2 trials (Observational 1, Phase 2 1) 2005: 1 trials (Not applicable 1) 2006: 1 trials (Phase 2 1) 2007: 1 trials (Observational 1) 2008: 1 trials (Observational 1) 2009: 6 trials (Observational 1, Not applicable 2, Phase 3 1, Phase 2/3 1, Phase 1 1) 2011: 3 trials (Observational 1, Phase 4 1, Phase 3 1) 2012: 4 trials (Observational 1, Not applicable 1, Phase 4 1, Phase 2 1) 2013: 4 trials (Observational 3, Not applicable 1) 2014: 3 trials (Observational 1, Not applicable 1, Phase 2 1) 2015: 7 trials (Observational 5, Not applicable 1, Phase 1/2 1) 2016: 4 trials (Observational 1, Not applicable 2, Phase 1 1) 2017: 4 trials (Observational 2, Not applicable 1, Phase 3 1) 2018: 2 trials (Observational 2) 2019: 2 trials (Observational 2) 2020: 2 trials (Observational 1, Not applicable 1) 2021: 6 trials (Observational 4, Not applicable 2) 2022: 2 trials (Observational 1, Not applicable 1) 2023: 3 trials (Observational 1, Not applicable 1, Phase 1 1) 2024: 4 trials (Observational 2, Phase 4 1, Phase 2 1) 2025: 11 trials (Observational 3, Not applicable 8)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 5
2025 11
2024 4
2023 3
2022 2
2021 6
2020 2
2019 2
2018 2
2017 4

Showing 10 of 25 earlier years.

Start your 14-day trial Email me all 25 earlier years as a PDF

No forecast is made for this condition: it averages 4.8 trial starts a year over the five years to September, under the 5 a year the method needs.

Prediction, not a registry value: median of 36 months from start to primary completion across 8 trials still running at the 2026-10-09 snapshot; registered median of 30 months across 41 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Femur Head Necrosis trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 3
Phase 1/2 2
Phase 2 6
Phase 2/3 1
Phase 3 5
Phase 4 5
Not applicable 25
Observational 37

How many Femur Head Necrosis trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 3
Recruiting 14
Enrolling by invitation 3
Active, not recruiting 11
Completed 30

Showing 5 of 9 statuses.

Start your 14-day trial Email me all 9 statuses as a PDF

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Femur Head Necrosis trials? (9)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Aesculap AG 6
Zimmer Biomet 5
Medacta International SA 4
Corin 2
DePuy Orthopaedics 2

Showing 5 of 9 sponsors.

Start your 14-day trial Email me all 9 sponsors as a PDF

Interventions as named in the registry (15)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Ropivacaine 2 % 2
Alendronate 20 mg 2
Core decompression/PREOB® implantation 2
EC Aspirin 1
15 ml Bupivacaine Hcl 0.25% injection 1

Showing 5 of 15 interventions.

Start your 14-day trial Email me all 15 interventions as a PDF

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Femur Head Necrosis trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
disease progression 21 1
Revision surgery for Infection 5 1
Dual Mobility Cup dislocation 3 1
Chest pain 2 1
Colitis ulcerative 2 1

Showing 5 of 10 adverse events.

Start your 14-day trial Email me all 10 adverse events as a PDF

Which publications cover Femur Head Necrosis? (97)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Does Adjunction of Autologous Osteoblastic Cells Improve the Results of Core Decompression in Early-stage Femoral Head Osteonecrosis? A Double-blind, Randomized Trial. Clinical orthopaedics and related research 2023 Yes
Avascular Necrosis of Femoral Head-Overview and Current State of the Art. International journal of environmental research and public health 2022 Yes
Mapping and Crosswalk of the Oxford Hip Score and Different Versions of the Hip Disability and Osteoarthritis Outcome Score. Clinical orthopaedics and related research 2021 Yes
10-year follow-up results of the prospective, double-blinded, randomized, controlled study on autologous bone marrow buffy coat grafting combined with core decompression in patients with avascular necrosis of the femoral head. Stem cell research & therapy 2020 Yes
BONE PERFUSION AND ADIPOSITY BEYOND THE NECROTIC ZONE IN FEMORAL HEAD OSTEONECROSIS: A QUANTITATIVE MRI STUDY. European journal of radiology 2020 Yes

Showing 5 of 97 publications.

Start your 14-day trial Email me the first 50 publications as a PDF

Prevalence (2)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Familial avascular necrosis of femoral head Annual incidence 1-9 / 100 000 United States US Unspecified
Familial avascular necrosis of femoral head Point prevalence Unknown Worldwide Not stated Unspecified

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: rare-disease identity.

Browse all condition evidence pages