Condition (MeSH)
Osteoporosis
ClinicalTrials.gov lists 1,757 trials for Osteoporosis or a narrower condition beneath it. Eli Lilly and Company has the most among industry and government lead sponsors, with 45.
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Trials per phase (log scale)
1 more section with rows
1,553 of the 1,757 trials are tagged with Osteoporosis itself; the rest are tagged with a narrower condition beneath it.
When did Osteoporosis trials start? (37)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
- Other (Expanded access)
Top of scale: 97
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 56 |
| 2025 | 66 |
| 2024 | 69 |
| 2023 | 85 |
| 2022 | 63 |
| 2021 | 77 |
| 2020 | 51 |
| 2019 | 72 |
| 2018 | 59 |
| 2017 | 57 |
Showing 10 of 37 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 72 trials starting in 2026 and about 67 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 74 trials still running at the 2026-10-09 snapshot; registered median of 26 months across 1,156 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Osteoporosis trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 116 |
| Phase 1/2 | 17 |
| Phase 2 | 151 |
| Phase 2/3 | 15 |
| Phase 3 | 228 |
| Phase 4 | 219 |
| Not applicable | 522 |
| Observational | 488 |
| Expanded access | 1 |
How many Osteoporosis trials are recruiting? (10)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 48 |
| Recruiting | 109 |
| Enrolling by invitation | 13 |
| Active, not recruiting | 50 |
| Completed | 1,180 |
Showing 5 of 10 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Osteoporosis trials? (9)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Eli Lilly and Company | 45 |
| Amgen | 41 |
| GlaxoSmithKline | 24 |
| Hoffmann-La Roche | 24 |
| Merck Sharp & Dohme LLC | 24 |
Showing 5 of 9 sponsors.
Which drugs are being tested for Osteoporosis? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| DENOSUMAB | 99 |
| Calcium/Vitamin D | 28 |
| Antacid | 21 |
| Calcium-vitamin D3 | 19 |
| Odanacatib | 14 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Transdermal Teriparatide | 101 |
| Alendronate 20 mg | 80 |
| acid Zoledronic | 77 |
| risedronate DR (Phase III clinical supply) | 50 |
| Romosozumab 90 mg/mL | 26 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Osteoporosis trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Pneumonia | 1,071 | 76 |
| Osteoarthritis | 961 | 57 |
| Atrial fibrillation | 618 | 53 |
| Cerebrovascular accident | 499 | 45 |
| Cholelithiasis | 436 | 48 |
Showing 5 of 10 adverse events.
Which publications cover Osteoporosis? (1,664)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| The Inflammation-Energy Metabolism Axis: A Central Driver of Sarcopenia-Osteoporosis: A Narrative Review. | Calcified tissue international | 2026 | Yes |
| Bone density and remodeling after discontinuation of sequential therapy for premenopausal idiopathic osteoporosis. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2026 | Yes |
| Early-life malnutrition exposure associated with higher osteoporosis risk in adulthood: a large-scale cross-sectional study. | International journal of surgery (London, England) | 2025 | Yes |
| Male osteoporosis: the impact of lifestyle, from nutrition to physical activity. | Journal of endocrinological investigation | 2025 | Yes |
| Addressing healthcare disparities and improving osteoporosis management in rural communities: a cluster randomized control trial. | Archives of osteoporosis | 2025 | Yes |
Showing 5 of 1,664 publications.
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.