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Condition (MeSH)

Osteoporosis, Postmenopausal

ClinicalTrials.gov lists 329 trials for Osteoporosis, Postmenopausal or a narrower condition beneath it. Eli Lilly and Company has the most among industry and government lead sponsors, with 25.

MeSH D015663 Musculoskeletal Diseases C05 C18
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Phase 1 Phase 1 23 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 31 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 73 Phase 4 Phase 4 71 Not applicable Not applicable 70 Observational Observational 57 Phase 1 Phase 1 23 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 31 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 73 Phase 4 Phase 4 71 Not applicable Not applicable 70 Observational Observational 57

Trials per phase (log scale)

1 more section with rows

329 of the 329 trials are tagged with Osteoporosis, Postmenopausal itself; the rest are tagged with a narrower condition beneath it.

Get the Osteoporosis, Postmenopausal report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Osteoporosis, Postmenopausal trials start? (32)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access)

Top of scale: 25

1994: 1 trials (Phase 3 1) 1995: 1 trials (Phase 3 1) 1996: 1 trials (Phase 3 1) 1998: 2 trials (Phase 3 1, Phase 2 1) 1999: 2 trials (Phase 3 1, Phase 2 1) 2000: 1 trials (Phase 2 1) 2001: 3 trials (Phase 4 1, Phase 3 2) 2002: 11 trials (Observational 1, Not applicable 1, Phase 4 2, Phase 3 6, Phase 2 1) 2003: 14 trials (Phase 4 6, Phase 3 6, Phase 2 1, Phase 1 1) 2004: 20 trials (Observational 1, Phase 4 10, Phase 3 7, Phase 2 2) 2005: 6 trials (Not applicable 1, Phase 4 2, Phase 3 2, Phase 1 1) 2006: 21 trials (Observational 2, Not applicable 1, Phase 4 9, Phase 3 4, Phase 2 2, Phase 1 3) 2007: 12 trials (Other 1, Observational 1, Not applicable 2, Phase 4 3, Phase 3 3, Phase 2 2) 2008: 8 trials (Observational 4, Not applicable 1, Phase 4 1, Phase 3 1, Phase 1 1) 2009: 16 trials (Observational 4, Phase 4 2, Phase 3 5, Phase 2 4, Phase 1 1) 2010: 9 trials (Observational 4, Not applicable 2, Phase 1 3) 2011: 12 trials (Observational 2, Not applicable 3, Phase 4 1, Phase 3 4, Phase 2 2) 2012: 16 trials (Observational 2, Not applicable 3, Phase 4 3, Phase 3 5, Phase 2 3) 2013: 5 trials (Not applicable 1, Phase 4 2, Phase 3 2) 2014: 6 trials (Observational 1, Not applicable 1, Phase 4 1, Phase 3 2, Phase 1 1) 2015: 7 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 2/3 1, Phase 1 2) 2016: 6 trials (Not applicable 3, Phase 4 3) 2017: 14 trials (Observational 2, Not applicable 6, Phase 4 3, Phase 3 1, Phase 2 1, Phase 1/2 1) 2018: 17 trials (Observational 4, Not applicable 7, Phase 4 1, Phase 3 2, Phase 2 1, Phase 1/2 1, Phase 1 1) 2019: 25 trials (Observational 7, Not applicable 7, Phase 4 2, Phase 3 6, Phase 1 3) 2020: 10 trials (Observational 3, Not applicable 3, Phase 3 1, Phase 2 1, Phase 1 2) 2021: 22 trials (Observational 3, Not applicable 6, Phase 4 5, Phase 3 5, Phase 2 1, Phase 1 2) 2022: 18 trials (Observational 4, Not applicable 6, Phase 4 4, Phase 3 2, Phase 2 2) 2023: 13 trials (Observational 3, Not applicable 4, Phase 4 5, Phase 3 1) 2024: 5 trials (Observational 3, Not applicable 1, Phase 2 1) 2025: 13 trials (Observational 1, Not applicable 7, Phase 4 3, Phase 2 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 10
2025 13
2024 5
2023 13
2022 18
2021 22
2020 10
2019 25
2018 17
2017 14

Forecast of the full-year count, planned starts included, not rows of this table: about 11 trials starting in 2026 and about 11 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 15 trials still running at the 2026-10-09 snapshot; registered median of 22 months across 228 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Osteoporosis, Postmenopausal trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 23
Phase 1/2 2
Phase 2 31
Phase 2/3 1
Phase 3 73
Phase 4 71
Not applicable 70
Observational 57
Expanded access 1

How many Osteoporosis, Postmenopausal trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 6
Recruiting 17
Enrolling by invitation 1
Active, not recruiting 9
Completed 245

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Osteoporosis, Postmenopausal trials? (12)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Eli Lilly and Company 25
Amgen 24
Hoffmann-La Roche 21
Sanofi 10
Organon and Co 9

Which drugs are being tested for Osteoporosis, Postmenopausal? (6)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
DENOSUMAB 46
Antacid 8
Abaloparatide 7
Calcium/Vitamin D 7
Calcium-vitamin D3 6

Interventions as named in the registry (9)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Transdermal Teriparatide 36
Alendronate 20 mg 22
risedronate DR (Phase III clinical supply) 18
acid Zoledronic 17
Romosozumab 90 mg/mL 13

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Osteoporosis, Postmenopausal trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Osteoarthritis 794 30
Pneumonia 780 37
Atrial fibrillation 471 26
Radius fracture 370 22
Cataract 366 18

Which publications cover Osteoporosis, Postmenopausal? (767)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Proposed Denosumab Biosimilar SB16 vs Reference Denosumab in Postmenopausal Osteoporosis: Phase 3 Results Up to Month 12. The Journal of clinical endocrinology and metabolism 2025 Yes
Romosozumab improves microarchitecture as assessed by tissue thickness-adjusted trabecular bone score in postmenopausal women with osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2025 Yes
Romosozumab Improves Tissue Thickness-Adjusted Trabecular Bone Score in Women With Osteoporosis and Diabetes. The Journal of clinical endocrinology and metabolism 2025 Yes
Strength training for osteoporosis prevention during early menopause (STOP-EM): a pilot study protocol for a single centre randomised waitlisted control trial in Canada. BMJ open 2025 Yes
Long-term adherence to anti-osteoporosis medication and determinants of adherence in the population-based screening trial ROSE. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2025 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

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