Skip to content
Pharma Observatory a Scientist.com platform

Condition (MeSH)

Otorhinolaryngologic Neoplasms

ClinicalTrials.gov lists 1,454 trials for Otorhinolaryngologic Neoplasms or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 51.

MeSH D010039 Neoplasms Neoplasm C04 C09
Email me this page as a PDF

Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Phase 1 Phase 1 126 Phase 1/2 Phase 1/2 81 Phase 2 Phase 2 458 Phase 2/3 Phase 2/3 24 Phase 3 Phase 3 188 Phase 4 Phase 4 12 Not applicable Not applicable 272 Observational Observational 291 Phase 1 Phase 1 126 Phase 1/2 Phase 1/2 81 Phase 2 Phase 2 458 Phase 2/3 Phase 2/3 24 Phase 3 Phase 3 188 Phase 4 Phase 4 12 Not applicable Not applicable 272 Observational Observational 291

Trials per phase (log scale)

1 more section with rows

14 of the 1,454 trials are tagged with Otorhinolaryngologic Neoplasms itself; the rest are tagged with a narrower condition beneath it.

Get the Otorhinolaryngologic Neoplasms report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Otorhinolaryngologic Neoplasms trials start? (33)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 3 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 117

1994: 1 trials (Phase 3 1) 1995: 2 trials (Observational 1, Phase 2 1) 1996: 6 trials (Observational 1, Not applicable 1, Phase 2/3 1, Phase 2 2, Phase 1 1) 1997: 5 trials (Phase 2 3, Phase 1/2 2) 1998: 5 trials (Observational 1, Phase 2 3, Phase 1 1) 1999: 11 trials (Not applicable 3, Phase 2 4, Phase 1/2 1, Phase 1 3) 2000: 10 trials (Not applicable 1, Phase 3 3, Phase 2 2, Phase 1/2 2, Phase 1 2) 2001: 15 trials (Observational 4, Not applicable 2, Phase 3 2, Phase 2 3, Phase 1/2 1, Phase 1 3) 2002: 5 trials (Observational 2, Phase 2 2, Phase 1 1) 2003: 10 trials (Observational 3, Phase 3 1, Phase 2 3, Phase 1/2 2, Phase 1 1) 2004: 10 trials (Observational 1, Phase 3 3, Phase 2 3, Phase 1/2 1, Phase 1 2) 2005: 20 trials (Observational 7, Not applicable 1, Phase 3 2, Phase 2 5, Phase 1 5) 2006: 26 trials (Observational 6, Not applicable 4, Phase 4 1, Phase 3 5, Phase 2 6, Phase 1 4) 2007: 37 trials (Observational 8, Not applicable 5, Phase 4 1, Phase 3 3, Phase 2 13, Phase 1/2 2, Phase 1 5) 2008: 28 trials (Observational 6, Not applicable 5, Phase 4 1, Phase 3 1, Phase 2/3 2, Phase 2 9, Phase 1/2 1, Phase 1 3) 2009: 28 trials (Observational 3, Not applicable 4, Phase 3 6, Phase 2 9, Phase 1/2 2, Phase 1 4) 2010: 35 trials (Observational 9, Not applicable 6, Phase 2 15, Phase 1/2 1, Phase 1 4) 2011: 32 trials (Observational 5, Not applicable 5, Phase 3 4, Phase 2/3 2, Phase 2 13, Phase 1 3) 2012: 35 trials (Observational 9, Not applicable 4, Phase 3 4, Phase 2 13, Phase 1/2 3, Phase 1 2) 2013: 36 trials (Observational 6, Not applicable 9, Phase 3 6, Phase 2/3 1, Phase 2 8, Phase 1/2 1, Phase 1 5) 2014: 45 trials (Observational 6, Not applicable 11, Phase 3 6, Phase 2/3 2, Phase 2 16, Phase 1/2 1, Phase 1 3) 2015: 57 trials (Observational 11, Not applicable 13, Phase 4 3, Phase 3 10, Phase 2 11, Phase 1/2 5, Phase 1 4) 2016: 67 trials (Observational 14, Not applicable 14, Phase 4 1, Phase 3 9, Phase 2 20, Phase 1/2 7, Phase 1 2) 2017: 71 trials (Observational 20, Not applicable 15, Phase 3 6, Phase 2 21, Phase 1/2 4, Phase 1 5) 2018: 93 trials (Observational 20, Not applicable 21, Phase 4 1, Phase 3 12, Phase 2/3 2, Phase 2 28, Phase 1/2 5, Phase 1 4) 2019: 84 trials (Observational 13, Not applicable 24, Phase 3 7, Phase 2/3 2, Phase 2 23, Phase 1/2 6, Phase 1 9) 2020: 85 trials (Observational 16, Not applicable 12, Phase 4 1, Phase 3 14, Phase 2 32, Phase 1/2 2, Phase 1 8) 2021: 91 trials (Observational 19, Not applicable 19, Phase 3 9, Phase 2/3 2, Phase 2 34, Phase 1/2 3, Phase 1 5) 2022: 117 trials (Observational 22, Not applicable 25, Phase 3 12, Phase 2/3 4, Phase 2 38, Phase 1/2 6, Phase 1 10) 2023: 97 trials (Observational 26, Not applicable 18, Phase 3 16, Phase 2/3 2, Phase 2 23, Phase 1/2 6, Phase 1 6) 2024: 101 trials (Observational 24, Not applicable 17, Phase 4 1, Phase 3 13, Phase 2/3 3, Phase 2 35, Phase 1/2 3, Phase 1 5) 2025: 100 trials (Observational 16, Not applicable 18, Phase 4 1, Phase 3 20, Phase 2 32, Phase 1/2 6, Phase 1 7)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 78
2025 100
2024 101
2023 97
2022 117
2021 91
2020 85
2019 84
2018 93
2017 71

Forecast of the full-year count, planned starts included, not rows of this table: about 99 trials starting in 2026 and about 97 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 226 trials still running at the 2026-10-09 snapshot; registered median of 37 months across 610 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Otorhinolaryngologic Neoplasms trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 126
Phase 1/2 81
Phase 2 458
Phase 2/3 24
Phase 3 188
Phase 4 12
Not applicable 272
Observational 291
Expanded access 2

How many Otorhinolaryngologic Neoplasms trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 94
Recruiting 274
Enrolling by invitation 7
Active, not recruiting 117
Completed 451

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Otorhinolaryngologic Neoplasms trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 51
Fujian Cancer Hospital 18

Which drugs are being tested for Otorhinolaryngologic Neoplasms? (6)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
PEMBROLIZUMAB 33
TORIPALIMAB 31
"Capecitabine" 30
CETUXIMAB 28
Camrelizumab 21

Interventions as named in the registry (9)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Cisplatin 1 173
Gemcitabine/Gemzar 58
Docetetaxel 40
Intensity-Modulated Radiotherapy 40
Radiation Therapy 39

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Otorhinolaryngologic Neoplasms trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Dysphagia 171 24
Mucositis oral 149 10
Nausea 111 23
Dehydration 110 26
Anorexia 86 13

Which publications cover Otorhinolaryngologic Neoplasms? (26)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Is there a patient population with squamous cell carcinoma of the head and neck region who might benefit from de-intensification of postoperative radiotherapy? : A monocentric retrospective analysis of a previously defined low-risk patient population treated with standard-of-care radiotherapy. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 2019 Yes
Haemorrhage following transoral robotic surgery. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 2018 Yes
Hypoxia imaging with [18F]-FMISO-PET for guided dose escalation with intensity-modulated radiotherapy in head-and-neck cancers. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 2015 Yes
Initial Experience of a Patient Navigation Model for Head and Neck Cancer. JAMA otolaryngology-- head & neck surgery 2015 Yes
Two-year results of a prospective preventive swallowing rehabilitation trial in patients treated with chemoradiation for advanced head and neck cancer. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2014 Yes

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages