Condition (MeSH)
Pigmentation Disorders
ClinicalTrials.gov lists 684 trials for Pigmentation Disorders or a narrower condition beneath it. Cosmetique Active International has the most among industry and government lead sponsors, with 13.
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Trials per phase
56 of the 684 trials are tagged with Pigmentation Disorders itself; the rest are tagged with a narrower condition beneath it.
When did Pigmentation Disorders trials start? (28)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 66
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 49 |
| 2025 | 59 |
| 2024 | 66 |
| 2023 | 64 |
| 2022 | 53 |
| 2021 | 51 |
| 2020 | 26 |
| 2019 | 37 |
| 2018 | 34 |
| 2017 | 31 |
Showing 10 of 28 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 64 trials starting in 2026 and about 62 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 21 months from start to primary completion across 56 trials still running at the 2026-10-09 snapshot; registered median of 12 months across 367 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Pigmentation Disorders trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 41 |
| Phase 1/2 | 15 |
| Phase 2 | 88 |
| Phase 2/3 | 19 |
| Phase 3 | 33 |
| Phase 4 | 62 |
| Not applicable | 283 |
| Observational | 143 |
How many Pigmentation Disorders trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 43 |
| Recruiting | 65 |
| Enrolling by invitation | 9 |
| Active, not recruiting | 29 |
| Completed | 333 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Pigmentation Disorders trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Cosmetique Active International | 13 |
| Cryonove Pharma | 9 |
| Incyte Corporation | 7 |
| National Human Genome Research Institute (NHGRI) | 7 |
Which drugs are being tested for Pigmentation Disorders? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Afamelanotide | 6 |
| Hydroquinone Cream | 5 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| acid tranexamic | 18 |
| Ruxolitinib 1.5% Cream | 8 |
| 1% Metformin | 7 |
| IR Tacrolimus | 5 |
| Triple Combination Cream | 5 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Pigmentation Disorders trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Operation NOS | 13 | 1 |
| Abdominal pain NOS | 8 | 1 |
| Respiratory failure | 7 | 3 |
| Anaemia NOS | 6 | 1 |
| Deep vein thrombosis | 5 | 3 |
Showing 5 of 10 adverse events.
Which publications cover Pigmentation Disorders? (82)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance. | Archives of dermatological research | 2023 | Yes |
| Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication. | International journal of molecular sciences | 2021 | Yes |
| Physical Management of Scar Tissue: A Systematic Review and Meta-Analysis. | Journal of alternative and complementary medicine (New York, N.Y.) | 2020 | Yes |
| Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders. | Ageing research reviews | 2020 | Yes |
| Comparison of the accuracy of human readers versus machine-learning algorithms for pigmented skin lesion classification: an open, web-based, international, diagnostic study. | The Lancet. Oncology | 2019 | Yes |
Showing 5 of 82 publications.
Sub-conditions in MeSH (6)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.