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Condition (MeSH)

Pneumococcal Infections

ClinicalTrials.gov lists 336 trials for Pneumococcal Infections or a narrower condition beneath it. Pfizer has the most among industry and government lead sponsors, with 62.

MeSH D011008 Infections C01
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Phase 1 Phase 1 50 Phase 1/2 Phase 1/2 14 Phase 2 Phase 2 32 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 121 Phase 4 Phase 4 45 Not applicable Not applicable 21 Observational Observational 52 Phase 1 Phase 1 50 Phase 1/2 Phase 1/2 14 Phase 2 Phase 2 32 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 121 Phase 4 Phase 4 45 Not applicable Not applicable 21 Observational Observational 52

Trials per phase (log scale)

298 of the 336 trials are tagged with Pneumococcal Infections itself; the rest are tagged with a narrower condition beneath it.

Get the Pneumococcal Infections report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Pneumococcal Infections trials start? (28)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 23

1995: 1 trials (Phase 3 1) 2000: 1 trials (Phase 2 1) 2001: 2 trials (Phase 4 1, Phase 3 1) 2002: 2 trials (Observational 1, Phase 1 1) 2003: 3 trials (Phase 4 1, Phase 1/2 1, Phase 1 1) 2004: 11 trials (Observational 3, Phase 4 2, Phase 2 1, Phase 1/2 3, Phase 1 2) 2005: 11 trials (Observational 3, Not applicable 1, Phase 4 2, Phase 3 3, Phase 2 1, Phase 1 1) 2006: 12 trials (Observational 3, Phase 4 1, Phase 3 8) 2007: 18 trials (Observational 1, Phase 3 14, Phase 2 1, Phase 1 2) 2008: 6 trials (Observational 2, Phase 4 2, Phase 3 2) 2009: 15 trials (Observational 3, Not applicable 1, Phase 3 9, Phase 1 2) 2010: 16 trials (Observational 4, Phase 4 5, Phase 3 3, Phase 2 1, Phase 1 3) 2011: 10 trials (Observational 4, Phase 4 1, Phase 3 3, Phase 1 2) 2012: 7 trials (Phase 4 2, Phase 3 3, Phase 2 2) 2013: 13 trials (Observational 2, Phase 4 6, Phase 3 3, Phase 1 2) 2014: 15 trials (Observational 2, Not applicable 4, Phase 4 1, Phase 3 3, Phase 2 3, Phase 1/2 2) 2015: 15 trials (Observational 4, Not applicable 2, Phase 4 1, Phase 3 2, Phase 2 3, Phase 1/2 2, Phase 1 1) 2016: 6 trials (Observational 1, Phase 4 2, Phase 1 3) 2017: 9 trials (Observational 2, Phase 4 1, Phase 3 1, Phase 2 3, Phase 1 2) 2018: 23 trials (Observational 2, Not applicable 2, Phase 4 1, Phase 3 11, Phase 2/3 1, Phase 2 4, Phase 1 2) 2019: 20 trials (Observational 1, Not applicable 2, Phase 4 1, Phase 3 11, Phase 2 1, Phase 1/2 2, Phase 1 2) 2020: 16 trials (Observational 3, Phase 4 1, Phase 3 9, Phase 1 3) 2021: 13 trials (Observational 2, Phase 4 5, Phase 3 5, Phase 1 1) 2022: 21 trials (Observational 3, Not applicable 2, Phase 4 3, Phase 3 10, Phase 2 1, Phase 1 2) 2023: 20 trials (Observational 2, Not applicable 1, Phase 4 2, Phase 3 5, Phase 2 2, Phase 1/2 2, Phase 1 6) 2024: 16 trials (Observational 2, Not applicable 2, Phase 3 3, Phase 2 4, Phase 1 5) 2025: 15 trials (Not applicable 1, Phase 4 2, Phase 3 3, Phase 2 3, Phase 1/2 1, Phase 1 5)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 14
2025 15
2024 16
2023 20
2022 21
2021 13
2020 16
2019 20
2018 23
2017 9

Forecast of the full-year count, planned starts included, not rows of this table: about 18 trials starting in 2026 and about 17 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 24 months from start to primary completion across 27 trials still running at the 2026-10-09 snapshot; registered median of 15 months across 259 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Pneumococcal Infections trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 50
Phase 1/2 14
Phase 2 32
Phase 2/3 1
Phase 3 121
Phase 4 45
Not applicable 21
Observational 52

How many Pneumococcal Infections trials are recruiting? (7)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 4
Recruiting 22
Active, not recruiting 13
Completed 263
Terminated 8

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Pneumococcal Infections trials? (12)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Pfizer 62
Merck Sharp & Dohme LLC 46
GlaxoSmithKline 31
Wyeth is now a wholly owned subsidiary of Pfizer 16
National Institute of Allergy and Infectious Diseases (NIAID) 9

Interventions as named in the registry (15)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
PREVNAR 13 27
VACCINE: 13-valent pneumococcal conjugate vaccine 26
PNEUMOVAX 24
V114 20
20 Valent Pneumococcal Conjugate Vaccine (20vPnC) 16

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Pneumococcal Infections trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Gastroenteritis 1,388 44
Pneumonia 1,304 57
Bronchiolitis 1,250 34
Dehydration 958 25
Asthmatic crisis 403 2

Which publications cover Pneumococcal Infections? (522)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (2)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages