Condition (MeSH)
Respiratory Distress Syndrome, Newborn
ClinicalTrials.gov lists 177 trials for Respiratory Distress Syndrome, Newborn or a narrower condition beneath it. NICHD Neonatal Research Network has the most among industry and government lead sponsors, with 5.
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Trials per phase (log scale)
121 of the 177 trials are tagged with Respiratory Distress Syndrome, Newborn itself; the rest are tagged with a narrower condition beneath it.
When did Respiratory Distress Syndrome, Newborn trials start? (29)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 15
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 14 |
| 2025 | 7 |
| 2024 | 15 |
| 2023 | 6 |
| 2022 | 10 |
| 2021 | 4 |
| 2020 | 12 |
| 2019 | 5 |
| 2018 | 9 |
| 2017 | 12 |
Showing 10 of 29 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 15 trials starting in 2026 and about 11 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 9 trials still running at the 2026-10-09 snapshot; registered median of 23 months across 111 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Respiratory Distress Syndrome, Newborn trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 6 |
| Phase 1/2 | 3 |
| Phase 2 | 15 |
| Phase 2/3 | 1 |
| Phase 3 | 10 |
| Phase 4 | 12 |
| Not applicable | 85 |
| Observational | 45 |
How many Respiratory Distress Syndrome, Newborn trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 14 |
| Recruiting | 11 |
| Enrolling by invitation | 3 |
| Active, not recruiting | 4 |
| Completed | 91 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Respiratory Distress Syndrome, Newborn trials? (2)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| NICHD Neonatal Research Network | 5 |
| Chiesi Farmaceutici S.p.A. | 4 |
Which drugs are being tested for Respiratory Distress Syndrome, Newborn? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Poractant Alfa | 6 |
| Betamethasone | 3 |
| MisoprostoL | 2 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| nCPAP | 7 |
| Dexamethasone/Dexamethasone acetate | 3 |
| Furosemide-IR | 2 |
| Inhaled Nitric Oxide (iNO) use | 2 |
| Poractant alfa instillation | 1 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Respiratory Distress Syndrome, Newborn trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Bronchopulmonary dysplasia | 25 | 2 |
| Retrolental fibro-dysplasia | 25 | 1 |
| Intraventricular haemorrhage neonatal | 24 | 2 |
| Patent ductus arteriosus repair | 23 | 1 |
| Sepsis neonatal | 21 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Respiratory Distress Syndrome, Newborn? (712)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| EIT guided evaluation of regional ventilation distributions in neonatal and pediatric ARDS: a prospective feasibility study. | Respiratory research | 2025 | Yes |
| Changes in lung aeration with high-flow nasal cannula compared to nasal CPAP in preterm infants. | Journal of perinatology : official journal of the California Perinatal Association | 2025 | Yes |
| Non-invasive intermittent positive pressure ventilation vs non-invasive high-frequency oscillatory ventilation as post-extubation support in extremely birth weight infants: a retrospective study. | European journal of pediatrics | 2025 | Yes |
| Automated oxygen control in preterm babies on respiratory support: protocol for a randomised crossover trial. | BMJ paediatrics open | 2025 | Yes |
| Serial lung ultrasound in predicting the need for surfactant and respiratory course in preterm infants-multicentre observational study (SLURP). | European journal of pediatrics | 2025 | Yes |
Showing 5 of 712 publications.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Infant acute respiratory distress syndrome | 70587 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Infant acute respiratory distress syndrome | 70587 | Exact | Orphadata Science knowledge files, Product 1 |
Sub-conditions in MeSH (2)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence.