Condition (MeSH)
Sprains and Strains
ClinicalTrials.gov lists 829 trials for Sprains and Strains or a narrower condition beneath it.
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Trials per phase (log scale)
166 of the 829 trials are tagged with Sprains and Strains itself; the rest are tagged with a narrower condition beneath it.
When did Sprains and Strains trials start? (28)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 3 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 86
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 62 |
| 2025 | 71 |
| 2024 | 64 |
| 2023 | 86 |
| 2022 | 73 |
| 2021 | 73 |
| 2020 | 44 |
| 2019 | 48 |
| 2018 | 40 |
| 2017 | 24 |
Showing 10 of 28 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 78 trials starting in 2026 and about 73 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 61 trials still running at the 2026-10-09 snapshot; registered median of 12 months across 501 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Sprains and Strains trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 13 |
| Phase 1/2 | 10 |
| Phase 2 | 29 |
| Phase 2/3 | 7 |
| Phase 3 | 26 |
| Phase 4 | 51 |
| Not applicable | 486 |
| Observational | 207 |
How many Sprains and Strains trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 59 |
| Recruiting | 76 |
| Enrolling by invitation | 9 |
| Active, not recruiting | 23 |
| Completed | 467 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which drugs are being tested for Sprains and Strains? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| METHYLPREDNISOLONE | 7 |
| Corticosteroid | 5 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| [PRP] platelet rich plasma | 12 |
| L:Lidocaine | 10 |
| Exercise | 9 |
| Triamcinolone Acetonide alone | 6 |
| Gabapentin 6% | 6 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Sprains and Strains trials report? (5)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Other | 3 | 1 |
| Arthritis | 2 | 1 |
| Fracture | 1 | 1 |
| Myocardial infarction | 1 | 1 |
| Nerve Injury - Digital-Median | 1 | 1 |
Which publications cover Sprains and Strains? (318)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Physiotherapists Approach in Lateral Ankle Sprain Rehabilitation: A Survey Study. | Journal of sport rehabilitation | 2026 | Yes |
| Epidemiology of ankle sprain and chronic ankle instability in elite adolescent dancesport athletes. | The Physician and sportsmedicine | 2025 | Yes |
| Effects of Protein Supplementation During Early Rehabilitation on Muscle Volume and Function After Acute Muscle Strain Injuries: A Randomized Controlled Trial. | Scandinavian journal of medicine & science in sports | 2025 | Yes |
| Tr14 gel for the treatment of acute ankle sprains: a plain language summary of the TRAUMED trial. | Journal of comparative effectiveness research | 2025 | Yes |
| Exploring the Role of Sprint Biomechanics in Hamstring Strain Injuries: A Current Opinion on Existing Concepts and Evidence. | Sports medicine (Auckland, N.Z.) | 2024 | Yes |
Showing 5 of 318 publications.
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.