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Condition (MeSH)

Ventricular Fibrillation

ClinicalTrials.gov lists 184 trials for Ventricular Fibrillation or a narrower condition beneath it. Boston Scientific Corporation has the most among industry and government lead sponsors, with 14.

MeSH D014693 Cardiovascular Diseases C14 C23
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Phase 1 Phase 1 2 Phase 1/2 Phase 1/2 1 Phase 2 Phase 2 6 Phase 2/3 Phase 2/3 3 Phase 3 Phase 3 17 Phase 4 Phase 4 13 Not applicable Not applicable 56 Observational Observational 86 Phase 1 Phase 1 2 Phase 1/2 Phase 1/2 1 Phase 2 Phase 2 6 Phase 2/3 Phase 2/3 3 Phase 3 Phase 3 17 Phase 4 Phase 4 13 Not applicable Not applicable 56 Observational Observational 86

Trials per phase (log scale)

184 of the 184 trials are tagged with Ventricular Fibrillation itself; the rest are tagged with a narrower condition beneath it.

Get the Ventricular Fibrillation report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Ventricular Fibrillation trials start? (33)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 11

1990: 1 trials (Observational 1) 1992: 1 trials (Phase 3 1) 1993: 1 trials (Observational 1) 1996: 1 trials (Observational 1) 1998: 1 trials (Phase 2/3 1) 1999: 3 trials (Phase 3 2, Phase 2 1) 2000: 2 trials (Not applicable 1, Phase 4 1) 2001: 2 trials (Phase 4 1, Phase 3 1) 2002: 4 trials (Observational 2, Not applicable 1, Phase 4 1) 2003: 5 trials (Observational 3, Not applicable 2) 2004: 9 trials (Observational 3, Phase 4 4, Phase 3 1, Phase 2/3 1) 2005: 7 trials (Observational 4, Not applicable 1, Phase 3 1, Phase 2 1) 2006: 8 trials (Observational 3, Not applicable 4, Phase 1 1) 2007: 9 trials (Observational 4, Not applicable 3, Phase 4 1, Phase 2 1) 2008: 11 trials (Observational 5, Not applicable 4, Phase 4 2) 2009: 5 trials (Observational 4, Not applicable 1) 2010: 4 trials (Observational 3, Phase 1 1) 2011: 6 trials (Observational 4, Not applicable 1, Phase 3 1) 2012: 6 trials (Observational 3, Not applicable 2, Phase 3 1) 2013: 7 trials (Observational 6, Not applicable 1) 2014: 4 trials (Observational 3, Phase 2 1) 2015: 3 trials (Observational 1, Not applicable 2) 2016: 5 trials (Observational 3, Not applicable 2) 2017: 4 trials (Observational 2, Not applicable 2) 2018: 8 trials (Observational 2, Not applicable 4, Phase 4 1, Phase 3 1) 2019: 9 trials (Observational 3, Not applicable 5, Phase 4 1) 2020: 6 trials (Observational 4, Not applicable 2) 2021: 8 trials (Observational 4, Not applicable 1, Phase 3 2, Phase 1/2 1) 2022: 5 trials (Observational 3, Not applicable 2) 2023: 8 trials (Observational 3, Not applicable 3, Phase 4 1, Phase 2 1) 2024: 6 trials (Not applicable 5, Phase 3 1) 2025: 7 trials (Observational 3, Not applicable 3, Phase 2/3 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 12
2025 7
2024 6
2023 8
2022 5
2021 8
2020 6
2019 9
2018 8
2017 4

Forecast of the full-year count, planned starts included, not rows of this table: about 12 trials starting in 2026 and about 8 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 10 trials still running at the 2026-10-09 snapshot; registered median of 37 months across 101 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Ventricular Fibrillation trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 2
Phase 1/2 1
Phase 2 6
Phase 2/3 3
Phase 3 17
Phase 4 13
Not applicable 56
Observational 86

How many Ventricular Fibrillation trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 10
Recruiting 21
Enrolling by invitation 2
Active, not recruiting 6
Completed 103

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Ventricular Fibrillation trials? (7)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Boston Scientific Corporation 14
Medtronic Cardiac Rhythm and Heart Failure 12
Biotronik SE & Co. KG 10
National Heart, Lung, and Blood Institute (NHLBI) 7
AtaCor Medical, Inc. 5

Which drugs are being tested for Ventricular Fibrillation? (5)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Sotalol 3
Mexiletine 2
Quinidine 2
Imipramine 2
Procainamide 2

Interventions as named in the registry (10)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
amiodarone amiodarone 5
MRI 2
Registry 2
Epinephrin 2
L:Lidocaine 2

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Ventricular Fibrillation trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
CHD hospitalization, 1st event post-randomization 728 1
Multiple heart failure symptoms 378 3
SAE-serious adverse events 279 1
Gastrointestinal 245 3
Pulmonary 221 4

Which publications cover Ventricular Fibrillation? (534)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
The impact of alternate defibrillation strategies on time in ventricular fibrillation. Resuscitation 2025 Yes
Epicardial ablation in high-risk Brugada syndrome to prevent ventricular fibrillation: results from a randomized clinical trial. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025 Yes
Double sequential external defibrillation for refractory ventricular fibrillation: the science, the controversies and the future. Journal of electrocardiology 2025 Yes
Reducing Unnecessary Implantable Cardioverter-Defibrillator Therapy With ENHANCED Programming: Long-Term Outcomes of the ENHANCED-ICD Study. Journal of cardiovascular electrophysiology 2025 Yes
Association of a mild or an important decline in left ventricular ejection fraction with ventricular tachyarrhythmias, sudden cardiac death, and all-cause death in heart failure with preserved ejection fraction: a report from the CHART-2 Study. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages