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Condition (MeSH)

Lymphoma, T-Cell

ClinicalTrials.gov lists 1,344 trials for Lymphoma, T-Cell or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 100.

MeSH D016399 Neoplasms Neoplasm C04 C15 C20 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 367 Phase 1/2 Phase 1/2 160 Phase 2 Phase 2 443 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 84 Phase 4 Phase 4 29 Not applicable Not applicable 100 Observational Observational 145 Phase 1 Phase 1 367 Phase 1/2 Phase 1/2 160 Phase 2 Phase 2 443 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 84 Phase 4 Phase 4 29 Not applicable Not applicable 100 Observational Observational 145

Trials per phase (log scale)

2 more sections with rows

276 of the 1,344 trials are tagged with Lymphoma, T-Cell itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Lymphoma, T-Cell trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 6 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access, Unknown)

Top of scale: 61

1990: 2 trials (Not applicable 1, Phase 2 1) 1991: 1 trials (Phase 2 1) 1992: 2 trials (Phase 2 2) 1993: 3 trials (Observational 1, Phase 2 2) 1994: 3 trials (Phase 2 1, Phase 1 2) 1995: 8 trials (Phase 4 2, Phase 3 1, Phase 2 2, Phase 1/2 1, Phase 1 2) 1996: 7 trials (Observational 2, Phase 2 1, Phase 1 4) 1997: 19 trials (Observational 1, Not applicable 2, Phase 3 2, Phase 2 4, Phase 1/2 1, Phase 1 9) 1998: 18 trials (Not applicable 1, Phase 3 2, Phase 2/3 1, Phase 2 6, Phase 1 8) 1999: 34 trials (Not applicable 3, Phase 3 7, Phase 2 7, Phase 1/2 2, Phase 1 15) 2000: 27 trials (Not applicable 4, Phase 4 1, Phase 3 3, Phase 2 11, Phase 1/2 3, Phase 1 5) 2001: 22 trials (Not applicable 2, Phase 4 1, Phase 3 2, Phase 2 8, Phase 1/2 2, Phase 1 7) 2002: 25 trials (Observational 1, Not applicable 6, Phase 4 1, Phase 3 2, Phase 2 2, Phase 1/2 2, Phase 1 11) 2003: 36 trials (Observational 1, Not applicable 6, Phase 3 4, Phase 2/3 1, Phase 2 12, Phase 1/2 6, Phase 1 6) 2004: 41 trials (Observational 5, Not applicable 6, Phase 4 1, Phase 2 17, Phase 1/2 1, Phase 1 11) 2005: 45 trials (Observational 4, Not applicable 4, Phase 3 3, Phase 2/3 1, Phase 2 23, Phase 1/2 4, Phase 1 6) 2006: 49 trials (Observational 5, Not applicable 3, Phase 3 3, Phase 2 17, Phase 1/2 6, Phase 1 15) 2007: 55 trials (Other 1, Observational 4, Not applicable 5, Phase 3 3, Phase 2 19, Phase 1/2 4, Phase 1 19) 2008: 50 trials (Observational 10, Not applicable 3, Phase 3 5, Phase 2 14, Phase 1/2 7, Phase 1 11) 2009: 44 trials (Other 1, Observational 5, Not applicable 3, Phase 3 1, Phase 2 15, Phase 1/2 6, Phase 1 13) 2010: 44 trials (Observational 7, Not applicable 4, Phase 4 1, Phase 3 2, Phase 2 13, Phase 1/2 4, Phase 1 13) 2011: 43 trials (Observational 4, Not applicable 1, Phase 4 3, Phase 3 2, Phase 2 17, Phase 1/2 5, Phase 1 11) 2012: 37 trials (Observational 3, Not applicable 1, Phase 4 3, Phase 3 3, Phase 2 13, Phase 1/2 4, Phase 1 10) 2013: 42 trials (Observational 4, Not applicable 1, Phase 3 6, Phase 2 11, Phase 1/2 5, Phase 1 15) 2014: 31 trials (Observational 2, Not applicable 2, Phase 4 3, Phase 2 11, Phase 1/2 5, Phase 1 8) 2015: 40 trials (Observational 6, Not applicable 3, Phase 4 1, Phase 3 3, Phase 2 14, Phase 1/2 4, Phase 1 9) 2016: 53 trials (Observational 9, Not applicable 2, Phase 4 4, Phase 3 1, Phase 2 20, Phase 1/2 5, Phase 1 12) 2017: 50 trials (Observational 4, Not applicable 9, Phase 4 1, Phase 3 3, Phase 2 16, Phase 1/2 6, Phase 1 11) 2018: 45 trials (Observational 5, Phase 4 1, Phase 3 3, Phase 2 22, Phase 1/2 6, Phase 1 8) 2019: 56 trials (Observational 7, Not applicable 2, Phase 4 2, Phase 3 1, Phase 2/3 1, Phase 2 20, Phase 1/2 6, Phase 1 17) 2020: 61 trials (Observational 4, Not applicable 2, Phase 3 1, Phase 2 25, Phase 1/2 9, Phase 1 20) 2021: 52 trials (Observational 5, Not applicable 2, Phase 4 2, Phase 3 3, Phase 2 19, Phase 1/2 5, Phase 1 16) 2022: 51 trials (Observational 6, Not applicable 5, Phase 4 1, Phase 3 2, Phase 2 9, Phase 1/2 11, Phase 1 17) 2023: 60 trials (Observational 10, Not applicable 7, Phase 4 1, Phase 3 1, Phase 2/3 1, Phase 2 17, Phase 1/2 9, Phase 1 14) 2024: 58 trials (Observational 11, Not applicable 3, Phase 3 2, Phase 2/3 1, Phase 2 19, Phase 1/2 9, Phase 1 13) 2025: 56 trials (Observational 11, Not applicable 2, Phase 3 7, Phase 2 13, Phase 1/2 11, Phase 1 12)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 51
2025 56
2024 58
2023 60
2022 51
2021 52
2020 61
2019 56
2018 45
2017 50

Showing 10 of 37 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 65 trials starting in 2026 and about 62 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 149 trials still running at the 2026-10-09 snapshot; registered median of 43 months across 798 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Lymphoma, T-Cell trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 367
Phase 1/2 160
Phase 2 443
Phase 2/3 7
Phase 3 84
Phase 4 29
Not applicable 100
Observational 145
Expanded access 8
Unknown 1

How many Lymphoma, T-Cell trials are recruiting? (12)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 59
Recruiting 155
Enrolling by invitation 4
Active, not recruiting 48
Available 2

Showing 5 of 12 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Lymphoma, T-Cell trials? (4)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 100
European Organisation for Research and Treatment of Cancer - EORTC 16
Seagen Inc. 16
National Institutes of Health Clinical Center (CC) 12

Which drugs are being tested for Lymphoma, T-Cell? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Cytoxan 129
Prednisone 53
RITUXIMAB 44
Busulfan 42

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
SQ Fludarabine 77
Etoposid 68
Peripheral blood stem cell transplantation 62
Doxorubicine 55
BrentuximabVedotin (BV) 53

Showing 5 of 11 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Lymphoma, T-Cell trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Febrile neutropenia 527 71
Pneumonia 309 73
Pyrexia 248 52
Sepsis 240 79
Neutrophil count decreased 225 37

Showing 5 of 10 adverse events.

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Which publications cover Lymphoma, T-Cell? (116)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
A Phase I Study of Romidepsin in Combination With Gemcitabine, Oxaliplatin, and Dexamethasone in Patients With Relapsed or Refractory Aggressive Lymphomas Enriched for T-Cell Lymphomas. Clinical lymphoma, myeloma & leukemia 2025 Yes
Safety and efficacy of tenalisib in combination with romidepsin in patients with relapsed/refractory T-cell lymphoma: results from a phase I/II open-label multicenter study. Haematologica 2024 Yes
Selinexor With Anti-PD-1 Antibody as a Potentially Effective Regimen for Patients With Natural Killer/T-Cell Lymphoma Failing Prior L-Asparaginase and PD-1 Blockade. The oncologist 2024 Yes
Tislelizumab and radiation therapy in low-risk early-stage extranodal natural killer/T-cell lymphoma, nasal type: a phase II study protocol. Future oncology (London, England) 2024 Yes
Phase II study of the novel antifolate agent pralatrexate in combination with the histone deacetylase inhibitor romidepsin for the treatment of patients with mature T-cell lymphoma. Leukemia & lymphoma 2024 Yes

Showing 5 of 116 publications.

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Prevalence (1)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
T-cell non-Hodgkin lymphoma Annual incidence 1-9 / 1 000 000 Europe Not stated Unspecified

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: rare-disease identity.

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