Skip to content
Pharma Observatory a Scientist.com platform

Condition (MeSH)

Craniomandibular Disorders

ClinicalTrials.gov lists 616 trials for Craniomandibular Disorders or a narrower condition beneath it.

MeSH D017271 Musculoskeletal Diseases C05 C07
Email me this page as a PDF

Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Phase 1 Phase 1 14 Phase 1/2 Phase 1/2 7 Phase 2 Phase 2 24 Phase 2/3 Phase 2/3 10 Phase 3 Phase 3 6 Phase 4 Phase 4 14 Not applicable Not applicable 368 Observational Observational 173 Phase 1 Phase 1 14 Phase 1/2 Phase 1/2 7 Phase 2 Phase 2 24 Phase 2/3 Phase 2/3 10 Phase 3 Phase 3 6 Phase 4 Phase 4 14 Not applicable Not applicable 368 Observational Observational 173

Trials per phase (log scale)

5 of the 616 trials are tagged with Craniomandibular Disorders itself; the rest are tagged with a narrower condition beneath it.

Get the Craniomandibular Disorders report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Craniomandibular Disorders trials start? (28)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 71

1994: 1 trials (Observational 1) 1997: 2 trials (Observational 1, Not applicable 1) 1999: 3 trials (Phase 2 3) 2002: 1 trials (Phase 2 1) 2003: 3 trials (Not applicable 2, Phase 1 1) 2004: 2 trials (Phase 2 1, Phase 1 1) 2005: 2 trials (Not applicable 1, Phase 1 1) 2006: 4 trials (Observational 1, Not applicable 2, Phase 2 1) 2007: 6 trials (Not applicable 3, Phase 4 1, Phase 2 1, Phase 1 1) 2008: 8 trials (Observational 4, Not applicable 2, Phase 2/3 1, Phase 1/2 1) 2009: 7 trials (Observational 2, Not applicable 3, Phase 1/2 1, Phase 1 1) 2010: 6 trials (Observational 1, Not applicable 5) 2011: 6 trials (Not applicable 5, Phase 3 1) 2012: 12 trials (Observational 2, Not applicable 6, Phase 4 1, Phase 3 1, Phase 2 1, Phase 1 1) 2013: 10 trials (Not applicable 7, Phase 4 1, Phase 2/3 1, Phase 1 1) 2014: 15 trials (Observational 3, Not applicable 11, Phase 1/2 1) 2015: 18 trials (Observational 3, Not applicable 10, Phase 2 2, Phase 1/2 1, Phase 1 2) 2016: 25 trials (Observational 3, Not applicable 19, Phase 2/3 1, Phase 2 1, Phase 1 1) 2017: 20 trials (Observational 5, Not applicable 12, Phase 2/3 1, Phase 2 1, Phase 1 1) 2018: 26 trials (Observational 7, Not applicable 14, Phase 4 1, Phase 3 1, Phase 2/3 1, Phase 2 1, Phase 1 1) 2019: 40 trials (Observational 15, Not applicable 22, Phase 4 2, Phase 2 1) 2020: 27 trials (Observational 10, Not applicable 15, Phase 2/3 1, Phase 2 1) 2021: 46 trials (Observational 14, Not applicable 24, Phase 4 1, Phase 2/3 2, Phase 2 3, Phase 1/2 2) 2022: 52 trials (Observational 18, Not applicable 30, Phase 4 1, Phase 3 1, Phase 2/3 1, Phase 2 1) 2023: 71 trials (Observational 18, Not applicable 46, Phase 4 2, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 1) 2024: 69 trials (Observational 17, Not applicable 49, Phase 4 2, Phase 2 1) 2025: 69 trials (Observational 23, Not applicable 42, Phase 3 2, Phase 2 1, Phase 1 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 62
2025 69
2024 69
2023 71
2022 52
2021 46
2020 27
2019 40
2018 26
2017 20

Forecast of the full-year count, planned starts included, not rows of this table: about 78 trials starting in 2026 and about 72 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 30 months from start to primary completion across 44 trials still running at the 2026-10-09 snapshot; registered median of 9 months across 379 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Craniomandibular Disorders trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 14
Phase 1/2 7
Phase 2 24
Phase 2/3 10
Phase 3 6
Phase 4 14
Not applicable 368
Observational 173

How many Craniomandibular Disorders trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 55
Recruiting 64
Enrolling by invitation 15
Active, not recruiting 10
Completed 357

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Interventions as named in the registry (15)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
type A botulinum toxin 13
Low Level Laser Therapy 11
Acupuncture 5
[PRP] platelet rich plasma 5
Physiotherapy 4

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Craniomandibular Disorders trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Abdominal pain upper 1 1
Acute kidney injury 1 1
Alcohol abuse 1 1
Appendicitis 1 1
Breast cancer metastatic 1 1

Which publications cover Craniomandibular Disorders? (14)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Symptoms of craniomandibular dysfunction in professional orchestra musicians. Occupational medicine (Oxford, England) 2014 Yes
Neuromuscular orthotics in the treatment of craniomandibular dysfunction and the effects on patients with multiple sclerosis: a pilot study. Cranio : the journal of craniomandibular practice 2011 Yes
Efficacy and co-morbidity of oral appliances in the treatment of obstructive sleep apnea-hypopnea: a systematic review. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 2004 Yes
Emotional stress and craniomandibular dysfunction in children. Cranio : the journal of craniomandibular practice 2001 Yes
Prevalence of modalities of headaches and bruxism among patients with craniomandibular disorder. Cranio : the journal of craniomandibular practice 1997 Yes

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.

Browse all condition evidence pages