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Condition (MeSH)

Mandibular Diseases

ClinicalTrials.gov lists 691 trials for Mandibular Diseases or a narrower condition beneath it.

MeSH D008336 Musculoskeletal Diseases C05 C07
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Phase 1 Phase 1 15 Phase 1/2 Phase 1/2 9 Phase 2 Phase 2 26 Phase 2/3 Phase 2/3 11 Phase 3 Phase 3 9 Phase 4 Phase 4 14 Not applicable Not applicable 418 Observational Observational 189 Phase 1 Phase 1 15 Phase 1/2 Phase 1/2 9 Phase 2 Phase 2 26 Phase 2/3 Phase 2/3 11 Phase 3 Phase 3 9 Phase 4 Phase 4 14 Not applicable Not applicable 418 Observational Observational 189

Trials per phase (log scale)

5 of the 691 trials are tagged with Mandibular Diseases itself; the rest are tagged with a narrower condition beneath it.

Get the Mandibular Diseases report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Mandibular Diseases trials start? (28)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 79

1994: 1 trials (Observational 1) 1997: 2 trials (Observational 1, Not applicable 1) 1999: 3 trials (Phase 2 3) 2002: 2 trials (Phase 2 2) 2003: 3 trials (Not applicable 2, Phase 1 1) 2004: 2 trials (Phase 2 1, Phase 1 1) 2005: 2 trials (Not applicable 1, Phase 1 1) 2006: 4 trials (Observational 1, Not applicable 2, Phase 2 1) 2007: 8 trials (Not applicable 3, Phase 4 1, Phase 3 1, Phase 2 1, Phase 1 2) 2008: 8 trials (Observational 4, Not applicable 2, Phase 2/3 1, Phase 1/2 1) 2009: 10 trials (Observational 3, Not applicable 4, Phase 3 1, Phase 1/2 1, Phase 1 1) 2010: 6 trials (Observational 1, Not applicable 5) 2011: 7 trials (Not applicable 5, Phase 3 1, Phase 2 1) 2012: 12 trials (Observational 2, Not applicable 6, Phase 4 1, Phase 3 1, Phase 2 1, Phase 1 1) 2013: 12 trials (Not applicable 9, Phase 4 1, Phase 2/3 1, Phase 1 1) 2014: 17 trials (Observational 4, Not applicable 12, Phase 1/2 1) 2015: 19 trials (Observational 3, Not applicable 11, Phase 2 2, Phase 1/2 1, Phase 1 2) 2016: 31 trials (Observational 4, Not applicable 23, Phase 3 1, Phase 2/3 1, Phase 2 1, Phase 1 1) 2017: 22 trials (Observational 6, Not applicable 13, Phase 2/3 1, Phase 2 1, Phase 1 1) 2018: 32 trials (Observational 9, Not applicable 18, Phase 4 1, Phase 3 1, Phase 2/3 1, Phase 2 1, Phase 1 1) 2019: 43 trials (Observational 16, Not applicable 24, Phase 4 2, Phase 2 1) 2020: 36 trials (Observational 14, Not applicable 20, Phase 2/3 1, Phase 2 1) 2021: 52 trials (Observational 15, Not applicable 28, Phase 4 1, Phase 2/3 2, Phase 2 3, Phase 1/2 3) 2022: 57 trials (Observational 18, Not applicable 34, Phase 4 1, Phase 3 1, Phase 2/3 2, Phase 2 1) 2023: 79 trials (Observational 18, Not applicable 54, Phase 4 2, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 1) 2024: 75 trials (Observational 18, Not applicable 53, Phase 4 2, Phase 2 1, Phase 1/2 1) 2025: 79 trials (Observational 26, Not applicable 49, Phase 3 2, Phase 2 1, Phase 1 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 64
2025 79
2024 75
2023 79
2022 57
2021 52
2020 36
2019 43
2018 32
2017 22

Forecast of the full-year count, planned starts included, not rows of this table: about 82 trials starting in 2026 and about 79 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 31 months from start to primary completion across 53 trials still running at the 2026-10-09 snapshot; registered median of 10 months across 415 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Mandibular Diseases trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 15
Phase 1/2 9
Phase 2 26
Phase 2/3 11
Phase 3 9
Phase 4 14
Not applicable 418
Observational 189

How many Mandibular Diseases trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 61
Recruiting 72
Enrolling by invitation 18
Active, not recruiting 14
Completed 390

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Interventions as named in the registry (15)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
type A botulinum toxin 13
Low Level Laser Therapy 11
Acupuncture 5
[PRP] platelet rich plasma 5
Physiotherapy 4

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Mandibular Diseases trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
metabolism 3 1
Abdominal pain upper 1 1
Acute kidney injury 1 1
Alcohol abuse 1 1
Appendicitis 1 1

Which publications cover Mandibular Diseases? (102)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (4)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.

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