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Condition (MeSH)

Ossification of Posterior Longitudinal Ligament

ClinicalTrials.gov lists 11 trials for Ossification of Posterior Longitudinal Ligament or a narrower condition beneath it. Medicrea International has the most among industry and government lead sponsors, with 1.

MeSH D017887 Musculoskeletal Diseases C05 C23
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Phase 4 Phase 4 1 Not applicable Not applicable 8 Observational Observational 2 Phase 4 Phase 4 1 Not applicable Not applicable 8 Observational Observational 2

Trials per phase

11 of the 11 trials are tagged with Ossification of Posterior Longitudinal Ligament itself; the rest are tagged with a narrower condition beneath it.

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When did Ossification of Posterior Longitudinal Ligament trials start? (6)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 4
  • Not applicable
  • Observational

Top of scale: 3

2011: 2 trials (Not applicable 1, Phase 4 1) 2016: 1 trials (Observational 1) 2017: 3 trials (Observational 1, Not applicable 2) 2018: 2 trials (Not applicable 2) 2021: 2 trials (Not applicable 2) 2023: 1 trials (Not applicable 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2023 1
2021 2
2018 2
2017 3
2016 1
2011 2

No forecast is made for this condition: it averages 0.2 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: none of the 11 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Ossification of Posterior Longitudinal Ligament trials in? (3)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 4 1
Not applicable 8
Observational 2

How many Ossification of Posterior Longitudinal Ligament trials are recruiting? (3)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Active, not recruiting 1
Completed 8
Unknown status 2

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Ossification of Posterior Longitudinal Ligament trials? (1)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Medicrea International 1

Interventions as named in the registry (2)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Arm I (MEP) 1
Arm II (A-FOLFOX/A-FOLFIRI) 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which publications cover Ossification of Posterior Longitudinal Ligament? (18)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
An open-label randomized multi-Centre study to evaluate anterior controllable Antedisplacement and fusion versus posterior Laminoplasty in patients with cervical ossification of the posterior longitudinal ligament: study design and analysis plan (STAR). BMC musculoskeletal disorders 2021 Yes
Analysis of the spinal cord angle for severe cervical ossification of the posterior longitudinal ligament: comparison between anterior controllable antedisplacement and fusion (ACAF) and posterior laminectomy. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2020 Yes
Comparison of Anterior Controllable Antedisplacement and Fusion With Posterior Laminoplasty in the Treatment of Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective, Randomized, and Control Study With at Least 1-Year Follow Up. Spine 2020 Yes
Anterior controllable antidisplacement and fusion surgery for the treatment of multilevel severe ossification of the posterior longitudinal ligament with myelopathy: preliminary clinical results of a novel technique. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2018 Yes
Morphometric Analysis of the Uncinate Process as a Landmark for Anterior Controllable Antedisplacement and Fusion Surgery: A Study of Radiologic Anatomy. World neurosurgery 2018 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.

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