Condition (MeSH)
Neurofibroma, Plexiform
ClinicalTrials.gov lists 62 trials for Neurofibroma, Plexiform or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 18.
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Trials per phase (log scale)
62 of the 62 trials are tagged with Neurofibroma, Plexiform itself; the rest are tagged with a narrower condition beneath it.
When did Neurofibroma, Plexiform trials start? (22)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 6
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 5 |
| 2024 | 3 |
| 2023 | 4 |
| 2022 | 2 |
| 2021 | 3 |
| 2020 | 1 |
| 2019 | 6 |
| 2018 | 4 |
| 2017 | 3 |
Showing 10 of 22 earlier years.
No forecast is made for this condition: it averages 3.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 10 trials still running at the 2026-10-09 snapshot; registered median of 56 months across 31 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Neurofibroma, Plexiform trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 8 |
| Phase 1/2 | 5 |
| Phase 2 | 23 |
| Phase 3 | 4 |
| Phase 4 | 1 |
| Not applicable | 5 |
| Observational | 14 |
| Expanded access | 2 |
How many Neurofibroma, Plexiform trials are recruiting? (10)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 12 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 13 |
| Available | 1 |
Showing 5 of 10 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Neurofibroma, Plexiform trials? (7)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Cancer Institute (NCI) | 18 |
| AstraZeneca | 6 |
| Novartis Pharmaceuticals | 3 |
| Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | 3 |
| SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany | 2 |
Showing 5 of 7 sponsors.
Which drugs are being tested for Neurofibroma, Plexiform? (7)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Selumetinib | 11 |
| GSK1120212 | 4 |
| EVEROLIMUS | 2 |
| Luvometinib | 2 |
| Imatinib | 2 |
Showing 5 of 7 drugs.
Interventions as named in the registry (8)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Pirfenidoneone | 3 |
| Vinblastin | 1 |
| Radiographic Evaluation | 1 |
| Nilotinib Pill | 1 |
| Mirdametinib (PD-0325901) oral capsule or dispersible tablet | 1 |
Showing 5 of 8 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Neurofibroma, Plexiform trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Pyrexia | 22 | 1 |
| Vomiting | 8 | 2 |
| Seizure | 7 | 3 |
| Alanine aminotransferase increased | 6 | 2 |
| Pneumonia | 6 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Neurofibroma, Plexiform? (55)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
Showing 5 of 55 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.