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Condition (MeSH)

Lichen Sclerosus et Atrophicus

ClinicalTrials.gov lists 29 trials for Lichen Sclerosus et Atrophicus or a narrower condition beneath it.

MeSH D018459 Skin and Connective Tissue Diseases C17 Listed by Orphanet as a rare disease
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Phase 2 Phase 2 4 Phase 3 Phase 3 3 Not applicable Not applicable 12 Observational Observational 10 Phase 2 Phase 2 4 Phase 3 Phase 3 3 Not applicable Not applicable 12 Observational Observational 10

Trials per phase

29 of the 29 trials are tagged with Lichen Sclerosus et Atrophicus itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Lichen Sclerosus et Atrophicus trials start? (15)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 2
  • Phase 3
  • Not applicable
  • Observational

Top of scale: 4

2006: 1 trials (Phase 2 1) 2011: 1 trials (Not applicable 1) 2014: 2 trials (Observational 1, Not applicable 1) 2015: 1 trials (Phase 3 1) 2016: 4 trials (Observational 2, Not applicable 2) 2017: 2 trials (Observational 1, Not applicable 1) 2018: 4 trials (Observational 1, Not applicable 3) 2019: 1 trials (Observational 1) 2020: 2 trials (Not applicable 2) 2021: 1 trials (Phase 3 1) 2022: 2 trials (Observational 1, Phase 2 1) 2023: 1 trials (Not applicable 1) 2024: 2 trials (Observational 1, Phase 2 1) 2025: 2 trials (Observational 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 3
2025 2
2024 2
2023 1
2022 2
2021 1
2020 2
2019 1
2018 4
2017 2

No forecast is made for this condition: it averages 2.2 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: 3 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Lichen Sclerosus et Atrophicus trials in? (4)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 2 4
Phase 3 3
Not applicable 12
Observational 10

How many Lichen Sclerosus et Atrophicus trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 2
Recruiting 4
Enrolling by invitation 1
Active, not recruiting 1
Completed 13

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Lichen Sclerosus et Atrophicus trials? (4)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
1st Federal Budgetary Healthcare Institution Volga District Medical Center 1
Incyte Corporation 1
Juna d.o.o. 1
LEO Pharma 1

Which drugs are being tested for Lichen Sclerosus et Atrophicus? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Delgocitinib 1
Clobetasol 1
Nemolizumab 1

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
[PRP] platelet rich plasma 2
No Interventions 1
Clobetasol 0.05% ointment 1
Ruxolitinib 1.5% Cream 1
Ruxolitinib Topical Cream 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Lichen Sclerosus et Atrophicus trials report? (1)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
COVID-19 pneumonia 1 1

Which publications cover Lichen Sclerosus et Atrophicus? (42)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Systemic Therapy for Lichen Sclerosus: A Systematic Review. Journal of lower genital tract disease 2024 Yes
Treatment of Refractory Vulvar Lichen Sclerosus With Methotrexate. Journal of lower genital tract disease 2024 Yes
EuroGuiderm guideline on lichen sclerosus-introduction into lichen sclerosus. Journal of the European Academy of Dermatology and Venereology : JEADV 2024 Yes
EuroGuiderm guideline on lichen sclerosus-Treatment of lichen sclerosus. Journal of the European Academy of Dermatology and Venereology : JEADV 2024 Yes
Human papilloma virus-16-specific CD8+ T-cell expansions characterize different clinical forms of lichen planus and not lichen sclerosus et atrophicus. Experimental dermatology 2023 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

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