Condition (MeSH)
Tuberculosis, Central Nervous System
ClinicalTrials.gov lists 32 trials for Tuberculosis, Central Nervous System or a narrower condition beneath it. ANRS, Emerging Infectious Diseases has the most among industry and government lead sponsors, with 2.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase
3 of the 32 trials are tagged with Tuberculosis, Central Nervous System itself; the rest are tagged with a narrower condition beneath it.
When did Tuberculosis, Central Nervous System trials start? (18)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 4
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 1 |
| 2024 | 2 |
| 2023 | 2 |
| 2022 | 1 |
| 2021 | 4 |
| 2020 | 1 |
| 2019 | 2 |
| 2018 | 2 |
| 2017 | 3 |
Showing 10 of 18 earlier years.
No forecast is made for this condition: it averages 1.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 27 months across 18 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Tuberculosis, Central Nervous System trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1/2 | 2 |
| Phase 2 | 11 |
| Phase 2/3 | 2 |
| Phase 3 | 5 |
| Phase 4 | 1 |
| Not applicable | 4 |
| Observational | 7 |
How many Tuberculosis, Central Nervous System trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 5 |
| Enrolling by invitation | 1 |
| Completed | 18 |
| Unknown status | 6 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Tuberculosis, Central Nervous System trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| ANRS, Emerging Infectious Diseases | 2 |
| BioVersys AG | 1 |
| Indian Council of Medical Research | 1 |
| National Institute of Allergy and Infectious Diseases (NIAID) | 1 |
Interventions as named in the registry (15)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Zyvox - linezolid | 5 |
| EC Aspirin | 4 |
| Dexamethasone/Dexamethasone acetate | 4 |
| Rifampicin | 4 |
| Isoniazida | 3 |
Showing 5 of 15 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Tuberculosis, Central Nervous System trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Aspiration | 2 | 1 |
| Acute Kidney Injury Secondary to Sepsis with Chest Focus | 1 | 1 |
| Aspiration Pneumonia | 1 | 1 |
| Drug-Induced Liver Injury | 1 | 1 |
| Fever With Hyponatremia and Hypokalemia | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Tuberculosis, Central Nervous System? (4)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Nos2<sup>-/-</sup> mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis. | Journal of neuroinflammation | 2022 | Yes |
| High mortality in adults hospitalized for active tuberculosis in a low HIV prevalence setting. | PloS one | 2014 | Yes |
| Neurologic manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome: a case series. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 2009 | Yes |
| Rapid diagnosis of CNS tuberculosis by a T-cell interferon-gamma release assay on cerebrospinal fluid mononuclear cells. | Infection | 2008 | Yes |
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.