Condition (MeSH)
Peri-Implantitis
ClinicalTrials.gov lists 318 trials for Peri-Implantitis or a narrower condition beneath it.
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Trials per phase (log scale)
318 of the 318 trials are tagged with Peri-Implantitis itself; the rest are tagged with a narrower condition beneath it.
When did Peri-Implantitis trials start? (21)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 34
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 26 |
| 2025 | 29 |
| 2024 | 30 |
| 2023 | 34 |
| 2022 | 28 |
| 2021 | 25 |
| 2020 | 21 |
| 2019 | 20 |
| 2018 | 28 |
| 2017 | 16 |
Showing 10 of 21 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 31 trials starting in 2026 and about 28 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 24 trials still running at the 2026-10-09 snapshot; registered median of 15 months across 187 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Peri-Implantitis trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 3 |
| Phase 1/2 | 1 |
| Phase 2 | 4 |
| Phase 2/3 | 1 |
| Phase 3 | 7 |
| Phase 4 | 17 |
| Not applicable | 167 |
| Observational | 118 |
How many Peri-Implantitis trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 25 |
| Recruiting | 36 |
| Enrolling by invitation | 11 |
| Active, not recruiting | 10 |
| Completed | 180 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which drugs are being tested for Peri-Implantitis? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Amoxicillin | 3 |
Interventions as named in the registry (14)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| 2% chlorhexidine | 11 |
| Control (placebo) group | 3 |
| Metronidazol | 3 |
| open flap debridement | 3 |
| Non-Surgical Intervention | 2 |
Showing 5 of 14 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Peri-Implantitis trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Death | 2 | 2 |
| Acute myocardial infarction | 1 | 1 |
| Colon cancer | 1 | 1 |
| Diverticulitis | 1 | 1 |
| Facial paralysis | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Peri-Implantitis? (329)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Effectiveness of 2D magnesium phosphate hydrogel for surgical decontamination of dental implants: A case series. | Journal of prosthodontics : official journal of the American College of Prosthodontists | 2025 | Yes |
| Evaluation of Peri-Implantitis through Fourier-Transform Infrared Spectroscopy on Saliva. | Journal of proteome research | 2025 | Yes |
| Treatment of peri-implant mucositis using an Er:YAG laser or an ultrasonic device: a randomized, controlled clinical trial. | International journal of implant dentistry | 2025 | Yes |
| Effect of Nonsurgical Mechanical Debridement With or Without Chlorhexidine Formulations in the Treatment of Peri-Implant Mucositis. A Randomized Placebo-Controlled Clinical Trial. | Clinical oral implants research | 2025 | Yes |
| Peri-implantitis reconstructive treatment implementing a titanium brush: 5-year extension results from a randomized clinical trial. | Journal of periodontology | 2025 | Yes |
Showing 5 of 329 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, prevalence, rare-disease identity, and sub-conditions in mesh.