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Condition (MeSH)

Periodontal Diseases

ClinicalTrials.gov lists 3,954 trials for Periodontal Diseases or a narrower condition beneath it. Colgate Palmolive has the most among industry and government lead sponsors, with 55.

MeSH D010510 Stomatognathic Diseases C07
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Phase 1 Phase 1 116 Phase 1/2 Phase 1/2 53 Phase 2 Phase 2 149 Phase 2/3 Phase 2/3 68 Phase 3 Phase 3 134 Phase 4 Phase 4 254 Not applicable Not applicable 2,297 Observational Observational 881 Phase 1 Phase 1 116 Phase 1/2 Phase 1/2 53 Phase 2 Phase 2 149 Phase 2/3 Phase 2/3 68 Phase 3 Phase 3 134 Phase 4 Phase 4 254 Not applicable Not applicable 2,297 Observational Observational 881

Trials per phase (log scale)

1 more section with rows

857 of the 3,954 trials are tagged with Periodontal Diseases itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Periodontal Diseases trials start? (29)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 8 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Unknown)

Top of scale: 379

1998: 4 trials (Observational 1, Not applicable 1, Phase 3 1, Phase 2 1) 1999: 4 trials (Not applicable 1, Phase 3 1, Phase 2 2) 2000: 6 trials (Observational 1, Not applicable 2, Phase 3 1, Phase 2 2) 2001: 4 trials (Observational 1, Not applicable 1, Phase 2 2) 2002: 7 trials (Not applicable 3, Phase 4 1, Phase 3 1, Phase 2 1, Phase 1/2 1) 2003: 10 trials (Observational 2, Not applicable 3, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 1) 2004: 11 trials (Observational 1, Not applicable 5, Phase 3 2, Phase 2 1, Phase 1/2 1, Phase 1 1) 2005: 14 trials (Observational 4, Not applicable 5, Phase 2 3, Phase 1/2 1, Phase 1 1) 2006: 21 trials (Observational 1, Not applicable 5, Phase 4 6, Phase 3 6, Phase 2/3 1, Phase 2 2) 2007: 31 trials (Observational 9, Not applicable 8, Phase 4 5, Phase 3 5, Phase 2 3, Phase 1/2 1) 2008: 51 trials (Observational 7, Not applicable 14, Phase 4 7, Phase 3 9, Phase 2 6, Phase 1/2 4, Phase 1 4) 2009: 41 trials (Observational 10, Not applicable 13, Phase 4 4, Phase 3 4, Phase 2 7, Phase 1/2 1, Phase 1 2) 2010: 67 trials (Observational 11, Not applicable 32, Phase 4 10, Phase 3 2, Phase 2/3 1, Phase 2 6, Phase 1/2 3, Phase 1 2) 2011: 62 trials (Observational 13, Not applicable 30, Phase 4 12, Phase 2/3 1, Phase 2 3, Phase 1 3) 2012: 95 trials (Other 1, Observational 17, Not applicable 41, Phase 4 17, Phase 3 5, Phase 2/3 2, Phase 2 8, Phase 1/2 1, Phase 1 3) 2013: 128 trials (Observational 27, Not applicable 55, Phase 4 21, Phase 3 3, Phase 2/3 8, Phase 2 12, Phase 1 2) 2014: 178 trials (Observational 25, Not applicable 92, Phase 4 20, Phase 3 7, Phase 2/3 15, Phase 2 8, Phase 1/2 5, Phase 1 6) 2015: 171 trials (Observational 35, Not applicable 82, Phase 4 17, Phase 3 8, Phase 2/3 10, Phase 2 10, Phase 1/2 5, Phase 1 4) 2016: 189 trials (Observational 40, Not applicable 112, Phase 4 18, Phase 3 1, Phase 2/3 4, Phase 2 5, Phase 1/2 1, Phase 1 8) 2017: 201 trials (Observational 31, Not applicable 132, Phase 4 15, Phase 3 6, Phase 2/3 3, Phase 2 7, Phase 1/2 3, Phase 1 4) 2018: 222 trials (Observational 55, Not applicable 134, Phase 4 13, Phase 3 5, Phase 2/3 4, Phase 2 5, Phase 1/2 3, Phase 1 3) 2019: 247 trials (Observational 48, Not applicable 157, Phase 4 14, Phase 3 4, Phase 2/3 2, Phase 2 14, Phase 1/2 2, Phase 1 6) 2020: 198 trials (Observational 51, Not applicable 114, Phase 4 11, Phase 3 4, Phase 2/3 2, Phase 2 6, Phase 1/2 4, Phase 1 6) 2021: 247 trials (Other 1, Observational 63, Not applicable 143, Phase 4 13, Phase 3 5, Phase 2/3 3, Phase 2 8, Phase 1/2 3, Phase 1 8) 2022: 296 trials (Observational 79, Not applicable 184, Phase 4 9, Phase 3 4, Phase 2/3 1, Phase 2 4, Phase 1/2 2, Phase 1 13) 2023: 370 trials (Observational 76, Not applicable 257, Phase 4 8, Phase 3 12, Phase 2/3 1, Phase 2 4, Phase 1/2 1, Phase 1 11) 2024: 379 trials (Observational 96, Not applicable 243, Phase 4 6, Phase 3 13, Phase 2/3 1, Phase 2 9, Phase 1/2 2, Phase 1 9) 2025: 375 trials (Observational 83, Not applicable 242, Phase 4 14, Phase 3 11, Phase 2/3 4, Phase 2 7, Phase 1/2 3, Phase 1 11)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 310
2025 375
2024 379
2023 370
2022 296
2021 247
2020 198
2019 247
2018 222
2017 201

Showing 10 of 29 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 370 trials starting in 2026 and about 370 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 34 months from start to primary completion across 280 trials still running at the 2026-10-09 snapshot; registered median of 12 months across 2,522 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Periodontal Diseases trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 116
Phase 1/2 53
Phase 2 149
Phase 2/3 68
Phase 3 134
Phase 4 254
Not applicable 2,297
Observational 881
Unknown 2

How many Periodontal Diseases trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 258
Recruiting 358
Enrolling by invitation 61
Active, not recruiting 136
Completed 2,387

Showing 5 of 9 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Periodontal Diseases trials? (1)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Colgate Palmolive 55

Which drugs are being tested for Periodontal Diseases? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Platelet Rich Fibrin 33
Amoxicillin 19

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
2% chlorhexidine 43
open flap debridement 40
Hyaluronic acid 1% 22
Metronidazol 22
Connective tissue graft 22

Showing 5 of 13 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Periodontal Diseases trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
PREMATURE DELIVERY 42 1
PRE-ECLAMPSIA 33 1
CHORIOAMNIONITIS 24 1
PREMATURE RUPTURE OF MEMBRANES 16 1
GESTATIONAL HYPERTENSION 15 1

Showing 5 of 10 adverse events.

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Which publications cover Periodontal Diseases? (782)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Patient-specific gingival recession system based on periodontal disease prediction. International journal of computerized dentistry 2025 Yes
Genetic Biomarkers for Periodontal Diseases: A Systematic Review. Journal of clinical periodontology 2025 Yes
The influence of periodontal disease and periodontal treatment on colorectal cancer. Radiology and oncology 2025 Yes
Determinants of post-stroke cognitive impairment in patients with periodontal disease. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Yes
PerioAI: A digital system for periodontal disease diagnosis from an intra-oral scan and cone-beam CT image. Cell reports. Medicine 2025 Yes

Showing 5 of 782 publications.

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Sub-conditions in MeSH (10)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

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