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Condition (MeSH)

Periodontitis

ClinicalTrials.gov lists 1,810 trials for Periodontitis or a narrower condition beneath it.

MeSH D010518 Stomatognathic Diseases C07
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Phase 1 Phase 1 67 Phase 1/2 Phase 1/2 27 Phase 2 Phase 2 79 Phase 2/3 Phase 2/3 49 Phase 3 Phase 3 45 Phase 4 Phase 4 121 Not applicable Not applicable 957 Observational Observational 465 Phase 1 Phase 1 67 Phase 1/2 Phase 1/2 27 Phase 2 Phase 2 79 Phase 2/3 Phase 2/3 49 Phase 3 Phase 3 45 Phase 4 Phase 4 121 Not applicable Not applicable 957 Observational Observational 465

Trials per phase (log scale)

1,198 of the 1,810 trials are tagged with Periodontitis itself; the rest are tagged with a narrower condition beneath it.

Get the Periodontitis report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Periodontitis trials start? (29)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 3 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 178

1998: 1 trials (Not applicable 1) 1999: 2 trials (Phase 3 1, Phase 2 1) 2000: 3 trials (Not applicable 2, Phase 2 1) 2001: 2 trials (Observational 1, Phase 2 1) 2002: 6 trials (Not applicable 3, Phase 3 1, Phase 2 1, Phase 1/2 1) 2003: 6 trials (Observational 1, Not applicable 2, Phase 3 2, Phase 2 1) 2004: 7 trials (Observational 1, Not applicable 3, Phase 3 1, Phase 1/2 1, Phase 1 1) 2005: 5 trials (Observational 2, Phase 2 2, Phase 1 1) 2006: 14 trials (Observational 1, Not applicable 5, Phase 4 4, Phase 3 3, Phase 2 1) 2007: 12 trials (Observational 5, Not applicable 4, Phase 4 3) 2008: 19 trials (Observational 4, Not applicable 4, Phase 4 4, Phase 3 3, Phase 2 2, Phase 1 2) 2009: 21 trials (Observational 6, Not applicable 6, Phase 4 1, Phase 3 3, Phase 2 4, Phase 1 1) 2010: 27 trials (Observational 5, Not applicable 12, Phase 4 6, Phase 3 1, Phase 2/3 1, Phase 2 1, Phase 1/2 1) 2011: 29 trials (Observational 7, Not applicable 11, Phase 4 8, Phase 2 1, Phase 1 2) 2012: 50 trials (Observational 9, Not applicable 17, Phase 4 12, Phase 3 3, Phase 2 6, Phase 1 3) 2013: 73 trials (Observational 17, Not applicable 29, Phase 4 10, Phase 3 2, Phase 2/3 6, Phase 2 7, Phase 1 2) 2014: 85 trials (Observational 13, Not applicable 39, Phase 4 7, Phase 3 4, Phase 2/3 11, Phase 2 5, Phase 1/2 2, Phase 1 4) 2015: 82 trials (Observational 20, Not applicable 31, Phase 4 8, Phase 3 4, Phase 2/3 8, Phase 2 7, Phase 1/2 3, Phase 1 1) 2016: 93 trials (Observational 17, Not applicable 52, Phase 4 13, Phase 2/3 4, Phase 2 2, Phase 1/2 1, Phase 1 4) 2017: 86 trials (Observational 12, Not applicable 56, Phase 4 6, Phase 3 1, Phase 2/3 3, Phase 2 4, Phase 1/2 3, Phase 1 1) 2018: 74 trials (Observational 20, Not applicable 37, Phase 4 6, Phase 3 2, Phase 2/3 3, Phase 2 3, Phase 1/2 1, Phase 1 2) 2019: 113 trials (Observational 26, Not applicable 67, Phase 4 5, Phase 3 1, Phase 2/3 2, Phase 2 8, Phase 1 4) 2020: 84 trials (Observational 22, Not applicable 43, Phase 4 6, Phase 3 1, Phase 2/3 1, Phase 2 3, Phase 1/2 4, Phase 1 4) 2021: 123 trials (Observational 42, Not applicable 61, Phase 4 6, Phase 3 1, Phase 2/3 2, Phase 2 6, Phase 1/2 2, Phase 1 3) 2022: 133 trials (Observational 40, Not applicable 79, Phase 4 3, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 7) 2023: 169 trials (Observational 36, Not applicable 114, Phase 4 2, Phase 3 5, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 8) 2024: 178 trials (Observational 56, Not applicable 109, Phase 3 2, Phase 2/3 1, Phase 2 4, Phase 1 6) 2025: 165 trials (Observational 49, Not applicable 94, Phase 4 6, Phase 3 2, Phase 2/3 3, Phase 2 2, Phase 1/2 3, Phase 1 6)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 139
2025 165
2024 178
2023 169
2022 133
2021 123
2020 84
2019 113
2018 74
2017 86

Forecast of the full-year count, planned starts included, not rows of this table: about 170 trials starting in 2026 and about 170 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 34 months from start to primary completion across 120 trials still running at the 2026-10-09 snapshot; registered median of 12 months across 1,155 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Periodontitis trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 67
Phase 1/2 27
Phase 2 79
Phase 2/3 49
Phase 3 45
Phase 4 121
Not applicable 957
Observational 465

How many Periodontitis trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 121
Recruiting 157
Enrolling by invitation 24
Active, not recruiting 62
Completed 1,090

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Periodontitis? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Platelet Rich Fibrin 13
Amoxicillin 13

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
open flap debridement 31
2% chlorhexidine 19
Metronidazol 17
SRP 16
Hyaluronic acid 1% 10

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Periodontitis trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
hospitalizations 9 1
Death 4 3
Hysterectomy 2 2
Abdominal hernia 1 1
Back pain 1 1

Which publications cover Periodontitis? (1,103)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.

Browse all condition evidence pages