Condition (MeSH)
Chronic Periodontitis
ClinicalTrials.gov lists 355 trials for Chronic Periodontitis or a narrower condition beneath it.
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Trials per phase
355 of the 355 trials are tagged with Chronic Periodontitis itself; the rest are tagged with a narrower condition beneath it.
When did Chronic Periodontitis trials start? (24)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 45
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 6 |
| 2025 | 7 |
| 2024 | 13 |
| 2023 | 10 |
| 2022 | 12 |
| 2021 | 12 |
| 2020 | 15 |
| 2019 | 17 |
| 2018 | 26 |
| 2017 | 25 |
Showing 10 of 24 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 8 trials starting in 2026 and about 9 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 30 months from start to primary completion across 11 trials still running at the 2026-10-09 snapshot; registered median of 12 months across 282 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Chronic Periodontitis trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 12 |
| Phase 1/2 | 10 |
| Phase 2 | 26 |
| Phase 2/3 | 25 |
| Phase 3 | 16 |
| Phase 4 | 50 |
| Not applicable | 153 |
| Observational | 63 |
How many Chronic Periodontitis trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 5 |
| Recruiting | 10 |
| Active, not recruiting | 5 |
| Completed | 266 |
| Terminated | 9 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which drugs are being tested for Chronic Periodontitis? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Platelet Rich Fibrin | 6 |
| ROSUVASTATIN | 4 |
| Amoxicillin | 4 |
| Aloe Vera Gel | 3 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| open flap debridement | 14 |
| (PDT) Photodynamic therapy | 6 |
| Metronidazol | 5 |
| SRP | 4 |
| 2% chlorhexidine | 3 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Chronic Periodontitis trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Abdominal hernia | 1 | 1 |
| Back pain | 1 | 1 |
| Brain neoplasm | 1 | 1 |
| Cast | 1 | 1 |
| Cellulitis and pulmonary embolism | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Chronic Periodontitis? (387)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Use of the Probiotic Limosilactobacillus reuteri as an Adjunct to Subgingival Instrumentation in the Treatment of Periodontitis Patients With Diabetes: A Randomised Clinical Trial. | Journal of clinical periodontology | 2026 | Yes |
| Clinical Treatment Endpoints After Active Periodontal Treatment and 10 Years of Supportive Periodontal Care: A Retrospective Cohort Study. | Journal of clinical periodontology | 2025 | Yes |
| Non-surgical periodontal therapy with and without hyaluronic acid gel in type 2 diabetic stage-II periodontitis patients: a randomized clinical trial. | BMC oral health | 2025 | Yes |
| Impact of allogeneic dental pulp stem cell injection on tissue regeneration in periodontitis: a multicenter randomized clinical trial. | Signal transduction and targeted therapy | 2025 | Yes |
| Clinical effect of Nd:YAG laser-assisted non-surgical periodontal treatment on stage II/III periodontitis. | Journal of dentistry | 2025 | Yes |
Showing 5 of 387 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, prevalence, rare-disease identity, and sub-conditions in mesh.