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Condition (MeSH)

Gingival Diseases

ClinicalTrials.gov lists 1,131 trials for Gingival Diseases or a narrower condition beneath it. Colgate Palmolive has the most among industry and government lead sponsors, with 50.

MeSH D005882 Stomatognathic Diseases C07
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Phase 1 Phase 1 31 Phase 1/2 Phase 1/2 12 Phase 2 Phase 2 47 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 66 Phase 4 Phase 4 80 Not applicable Not applicable 725 Observational Observational 162 Phase 1 Phase 1 31 Phase 1/2 Phase 1/2 12 Phase 2 Phase 2 47 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 66 Phase 4 Phase 4 80 Not applicable Not applicable 725 Observational Observational 162

Trials per phase (log scale)

1 more section with rows

86 of the 1,131 trials are tagged with Gingival Diseases itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Gingival Diseases trials start? (26)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Unknown)

Top of scale: 121

1999: 1 trials (Not applicable 1) 2002: 1 trials (Phase 4 1) 2003: 1 trials (Not applicable 1) 2004: 1 trials (Not applicable 1) 2005: 2 trials (Observational 1, Not applicable 1) 2006: 5 trials (Phase 4 1, Phase 3 3, Phase 2 1) 2007: 10 trials (Observational 1, Not applicable 2, Phase 4 1, Phase 3 4, Phase 2 2) 2008: 21 trials (Observational 2, Not applicable 6, Phase 3 6, Phase 2 4, Phase 1/2 2, Phase 1 1) 2009: 11 trials (Observational 1, Not applicable 2, Phase 4 2, Phase 3 1, Phase 2 3, Phase 1/2 1, Phase 1 1) 2010: 23 trials (Observational 1, Not applicable 13, Phase 4 4, Phase 2 2, Phase 1/2 1, Phase 1 2) 2011: 22 trials (Observational 2, Not applicable 14, Phase 4 4, Phase 2 1, Phase 1 1) 2012: 22 trials (Observational 3, Not applicable 14, Phase 4 3, Phase 2/3 1, Phase 2 1) 2013: 33 trials (Observational 5, Not applicable 15, Phase 4 7, Phase 3 2, Phase 2 4) 2014: 51 trials (Observational 3, Not applicable 29, Phase 4 11, Phase 3 2, Phase 2 3, Phase 1/2 1, Phase 1 2) 2015: 50 trials (Observational 4, Not applicable 35, Phase 4 4, Phase 3 2, Phase 2 1, Phase 1/2 1, Phase 1 3) 2016: 44 trials (Observational 6, Not applicable 33, Phase 4 2, Phase 2 2, Phase 1 1) 2017: 51 trials (Observational 6, Not applicable 36, Phase 4 4, Phase 3 2, Phase 2 2, Phase 1 1) 2018: 69 trials (Observational 10, Not applicable 48, Phase 4 5, Phase 3 1, Phase 2 2, Phase 1/2 2, Phase 1 1) 2019: 76 trials (Observational 10, Not applicable 53, Phase 4 5, Phase 3 1, Phase 2 1, Phase 1/2 2, Phase 1 4) 2020: 55 trials (Observational 10, Not applicable 33, Phase 4 3, Phase 3 3, Phase 2/3 1, Phase 2 3, Phase 1 2) 2021: 66 trials (Other 1, Observational 8, Not applicable 45, Phase 4 4, Phase 3 3, Phase 2/3 1, Phase 2 3, Phase 1 1) 2022: 74 trials (Observational 13, Not applicable 53, Phase 4 3, Phase 3 2, Phase 2 1, Phase 1 2) 2023: 109 trials (Observational 13, Not applicable 84, Phase 4 3, Phase 3 6, Phase 2 2, Phase 1 1) 2024: 120 trials (Observational 24, Not applicable 77, Phase 4 2, Phase 3 9, Phase 2 3, Phase 1/2 2, Phase 1 3) 2025: 121 trials (Observational 22, Not applicable 76, Phase 4 5, Phase 3 8, Phase 2/3 1, Phase 2 6, Phase 1 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 89
2025 121
2024 120
2023 109
2022 74
2021 66
2020 55
2019 76
2018 69
2017 51

Showing 10 of 26 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 110 trials starting in 2026 and about 110 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 34 months from start to primary completion across 91 trials still running at the 2026-10-09 snapshot; registered median of 10 months across 759 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Gingival Diseases trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 31
Phase 1/2 12
Phase 2 47
Phase 2/3 7
Phase 3 66
Phase 4 80
Not applicable 725
Observational 162
Unknown 1

How many Gingival Diseases trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 65
Recruiting 110
Enrolling by invitation 16
Active, not recruiting 33
Completed 728

Showing 5 of 9 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Gingival Diseases trials? (4)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Colgate Palmolive 50
Procter and Gamble 23
HALEON 12
GlaxoSmithKline 8

Which drugs are being tested for Gingival Diseases? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Platelet Rich Fibrin 12
Potassium Nitrate Toothpaste 8
Stannous Fluoride 6

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Connective tissue graft 20
Chlorhexidine mouthwash 14
Stannous Fluoride Toothpaste 13
2% chlorhexidine 13
Colgate Cavity Protection Toothpaste 10

Showing 5 of 12 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Gingival Diseases trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
PREMATURE DELIVERY 42 1
PRE-ECLAMPSIA 33 1
CHORIOAMNIONITIS 24 1
PREMATURE RUPTURE OF MEMBRANES 16 1
GESTATIONAL HYPERTENSION 15 1

Showing 5 of 10 adverse events.

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Which publications cover Gingival Diseases? (112)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Development and psychometric validation of the gum health experience questionnaire. Journal of clinical periodontology 2024 Yes
A large-cohort study of 2971 cases of epulis: focusing on risk factors associated with recurrence. BMC oral health 2023 Yes
Could dietary restrictions affect periodontal disease? A systematic review. Clinical oral investigations 2023 Yes
Vitamin C mesotherapy versus diode laser for the esthetic management of physiologic gingival hyperpigmentation: a randomized clinical trial. BMC oral health 2023 Yes
Effects of three orthodontic retainers on periodontal pathogens and periodontal parameters. Scientific reports 2023 Yes

Showing 5 of 112 publications.

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Sub-conditions in MeSH (7)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

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