Organization (Industry)
AGENUS INC
ClinicalTrials.gov lists AGENUS INC as lead sponsor of 31 trials. It has 41 active development programs and 6 approved assets.
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Trials started per year with this organization as sponsor or collaborator, 1990 onward. The series also counts trials where the organization is a collaborator; the lead-sponsor trial count does not.
2026 is partial: 3 registered with a 2026 start date. The hollow diamonds on the dashed line are a forecast of the full-year count, planned starts included: about 5 in 2026 and about 6 in 2027, the average of the 24 months through September, counted as registered and carried forward. The columns, the lighter one included, count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. This method has not been backtested on organizations. In backtests on conditions with as many trial starts a year as this organization (5 to 20), forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Logo Agenus, via Wikimedia Commons, Public domain. Shown to identify the organization; it may be a registered trademark.
This page covers AGENUS INC: 31 lead-sponsored trials and 2 legal-entity registrations.
Disease areas (39)
Shown in this order: most trials first.
| Disease area | Trials |
|---|---|
| Colorectal Neoplasms | 11 |
| Pancreatic Neoplasms | 6 |
| Uterine Cervical Neoplasms | 6 |
| Carcinoma, Non-Small-Cell Lung | 5 |
| Lung Neoplasms | 5 |
Showing 5 of 39 disease areas.
Trials by start year as sponsor or collaborator (20)
Shown in this order: most recent first. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Show the table of trials by start year as sponsor or collaborator
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 7 |
| 2024 | 9 |
| 2023 | 6 |
| 2022 | 3 |
| 2021 | 6 |
| 2020 | 1 |
| 2019 | 5 |
| 2017 | 4 |
| 2016 | 1 |
Showing 10 of 20 years.
Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
Active development programs (41)
Shown in this order: max phase, then active trials.
| Drug | Disease area | Max phase | Trials |
|---|---|---|---|
| Balstilimab | Uterine Cervical Neoplasms | Phase 3 | 5 |
| Botensilimab | Colorectal Neoplasms | Phase 2 | 2 |
| Balstilimab | Sarcoma | Phase 2 | 2 |
| Balstilimab | Hemangiosarcoma | Phase 2 | 2 |
| Balstilimab | Colorectal Neoplasms | Phase 2 | 1 |
Showing 5 of 41 active programs.
Approved assets (6)
Shown in this order: max phase first.
| Drug | Trials |
|---|---|
| GEMCITABINE | 2 |
| PEMETREXED | 1 |
| Irinotecan | 1 |
| TOPOTECAN | 1 |
| Vinorelbine | 1 |
Showing 5 of 6 approved assets.
Sponsor delivery record (1)
Enrollment hit target: the share of this sponsor's lead-sponsored trials whose actual enrollment reached the planned enrollment. On time: the share whose actual primary completion date was no later than the planned date. Each share counts only trials where we observed an estimated figure before the actual one, and n is that number of trials. Below 5 trials the count is shown as a fraction, not a percentage.
| Enrollment | Timeline |
|---|---|
| 59% hit target (n=17) | 43% on time (n=14) |
Journals published in (38)
Shown in this order: most published in first.
| Journal | Publications |
|---|---|
| Journal of clinical oncology : official journal of the American Society of Clinical Oncology | 4 |
| Journal of immunology (Baltimore, Md. : 1950) | 3 |
| The Lancet. Oncology | 3 |
| The New England journal of medicine | 3 |
| American journal of clinical oncology | 2 |
Showing 5 of 38 journals.
US granted patents (1)
Patents are not classified by disease area in the source, so this is the organization's overall portfolio, not a split by disease.
| US patents granted | Granted in the last 5 years | Most recent grant |
|---|---|---|
| 66 | 26 | 2025-12-09 |
SEC-reported annual financials (11)
Shown in this order: newest fiscal year first; SEC EDGAR XBRL companyfacts, USD as reported.
| Fiscal year | Revenue (USD) | Net income (USD) | R&D (USD) |
|---|---|---|---|
| 2025 | 114,196,000 | not reported | 79,338,000 |
| 2024 | 103,463,000 | not reported | 155,528,000 |
| 2023 | 156,314,000 | not reported | 234,569,000 |
| 2022 | 98,024,000 | not reported | 186,691,000 |
| 2021 | 295,665,000 | not reported | 178,608,000 |
| 2020 | 88,170,000 | not reported | 142,617,000 |
| 2019 | 150,048,000 | not reported | 168,339,000 |
| 2018 | 36,784,000 | not reported | 124,600,000 |
| 2017 | 42,877,000 | -120,692,492 | 116,125,000 |
| 2016 | 22,573,303 | -126,995,175 | 94,971,379 |
Showing 10 of 11 fiscal years.
Financing and grant events (31)
Shown in this order: most recent first.
| Date | Round type | Amount (USD) | Source |
|---|---|---|---|
| 2026-07-13 | Private placement | not disclosed | Sec extracted |
| 2026-07-13 | Private placement | not disclosed | Sec extracted |
| 2026-06-29 | Other financing | not disclosed | Sec extracted |
| 2026-01-15 | Private placement | 16,000,000 | Sec extracted |
| 2026-01-03 | Other financing | not disclosed | Sec extracted |
Showing 5 of 31 events.
FDA inspection record (1)
| Latest classification | Inspections |
|---|---|
| NAI | 1 |
Climate targets, as filed (1)
| Reporting year | Net-zero target |
|---|---|
| 2025 | not disclosed |
Workforce and board diversity, as filed (1)
| Reporting year | Workforce % women | Board % women |
|---|---|---|
| 2025 | not disclosed | not disclosed |
Organization relationships (17)
Shown in this order: most evidence first.
| Related organization | Relationship | Evidence |
|---|---|---|
| Government of the United States of America | Co sponsors trial with | 4 |
| Immune Oncology Research Institute | Co sponsors trial with | 2 |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Co sponsors trial with | 2 |
| University of California System | Co sponsors trial with | 1 |
| Dana-Farber Cancer Institute | Co sponsors trial with | 1 |
Showing 5 of 17 relationships.
Latest dated events (160)
Shown in this order: newest first.
| Date | Event | Source |
|---|---|---|
| 2026-09 | Trial started | Clinical trials (ClinicalTrials.gov) (ClinicalTrials.gov, U.S. National Library of Medicine; AACT database, Clinical Trials Transformation Initiative (CTTI)) |
| 2026-07-13 | Private placement | Funding rounds and grants (NIH RePORTER + SEC EDGAR) |
| 2026-07-13 | Private placement | Funding rounds and grants (NIH RePORTER + SEC EDGAR) |
| 2026-06-29 | Financing | Funding rounds and grants (NIH RePORTER + SEC EDGAR) |
| 2026-05-12 | Trial started | Clinical trials (ClinicalTrials.gov) (ClinicalTrials.gov, U.S. National Library of Medicine; AACT database, Clinical Trials Transformation Initiative (CTTI)) |
Showing 5 of 160 events.
Biomarker capability evidence (320)
Shown in this order: tier desc, then gene symbol.
| Gene | Role | Evidence |
|---|---|---|
| ALB | Trial collaborator | Named in trial inclusion criteria |
| ALB | Trial sponsor | Named in trial inclusion criteria |
| ALB | Trial collaborator | Named in trial inclusion criteria |
| ALB | Trial sponsor | Named in trial inclusion criteria |
| ALB | Trial sponsor | Named in trial inclusion criteria |
Showing 5 of 320 evidence rows.
Not on this page
Checked, with nothing recorded for this organization: companies grouped under this page, related companies not grouped here, fda warning letters, fda untitled letters, fda recalls, fda import refusals, manufacturing and distribution sites, clia clinical laboratory certificates, and biomarkers this organization publishes on.