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Condition (MeSH)

Lung Neoplasms

ClinicalTrials.gov lists 11,703 trials for Lung Neoplasms or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 309.

MeSH D008175 Neoplasms Neoplasm C04 C08
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Phase 1 Phase 1 1,805 Phase 1/2 Phase 1/2 998 Phase 2 Phase 2 3,238 Phase 2/3 Phase 2/3 119 Phase 3 Phase 3 989 Phase 4 Phase 4 158 Not applicable Not applicable 1,930 Observational Observational 2,420 Phase 1 Phase 1 1,805 Phase 1/2 Phase 1/2 998 Phase 2 Phase 2 3,238 Phase 2/3 Phase 2/3 119 Phase 3 Phase 3 989 Phase 4 Phase 4 158 Not applicable Not applicable 1,930 Observational Observational 2,420

Trials per phase (log scale)

2 more sections with rows

5,246 of the 11,703 trials are tagged with Lung Neoplasms itself; the rest are tagged with a narrower condition beneath it.

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When did Lung Neoplasms trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 23 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access, Unknown)

Top of scale: 793

1990: 2 trials (Not applicable 1, Phase 2 1) 1991: 2 trials (Phase 2 1, Phase 1 1) 1992: 3 trials (Observational 2, Phase 2 1) 1993: 10 trials (Observational 2, Not applicable 1, Phase 3 2, Phase 2 3, Phase 1 2) 1994: 9 trials (Not applicable 1, Phase 3 5, Phase 2 2, Phase 1 1) 1995: 15 trials (Observational 2, Not applicable 1, Phase 3 4, Phase 2 3, Phase 1/2 1, Phase 1 4) 1996: 23 trials (Observational 2, Not applicable 1, Phase 3 4, Phase 2/3 1, Phase 2 10, Phase 1/2 1, Phase 1 4) 1997: 28 trials (Observational 2, Phase 3 6, Phase 2 9, Phase 1/2 4, Phase 1 7) 1998: 60 trials (Observational 6, Not applicable 2, Phase 3 18, Phase 2 23, Phase 1/2 3, Phase 1 8) 1999: 70 trials (Observational 3, Not applicable 3, Phase 3 18, Phase 2 28, Phase 1/2 3, Phase 1 15) 2000: 99 trials (Observational 10, Not applicable 3, Phase 4 1, Phase 3 17, Phase 2/3 2, Phase 2 39, Phase 1/2 6, Phase 1 21) 2001: 94 trials (Observational 6, Not applicable 5, Phase 3 21, Phase 2/3 4, Phase 2 40, Phase 1/2 6, Phase 1 12) 2002: 131 trials (Observational 13, Not applicable 5, Phase 4 3, Phase 3 22, Phase 2/3 3, Phase 2 63, Phase 1/2 6, Phase 1 16) 2003: 165 trials (Observational 20, Not applicable 8, Phase 4 1, Phase 3 15, Phase 2 81, Phase 1/2 17, Phase 1 23) 2004: 196 trials (Observational 22, Not applicable 20, Phase 4 2, Phase 3 18, Phase 2/3 1, Phase 2 88, Phase 1/2 14, Phase 1 31) 2005: 223 trials (Observational 38, Not applicable 13, Phase 3 23, Phase 2/3 5, Phase 2 103, Phase 1/2 12, Phase 1 29) 2006: 295 trials (Observational 33, Not applicable 25, Phase 4 4, Phase 3 36, Phase 2/3 3, Phase 2 139, Phase 1/2 20, Phase 1 35) 2007: 288 trials (Other 1, Observational 39, Not applicable 19, Phase 4 6, Phase 3 33, Phase 2/3 5, Phase 2 110, Phase 1/2 20, Phase 1 55) 2008: 323 trials (Observational 52, Not applicable 27, Phase 4 11, Phase 3 36, Phase 2/3 1, Phase 2 119, Phase 1/2 31, Phase 1 46) 2009: 349 trials (Observational 60, Not applicable 42, Phase 4 7, Phase 3 32, Phase 2/3 4, Phase 2 116, Phase 1/2 20, Phase 1 68) 2010: 287 trials (Observational 75, Not applicable 39, Phase 4 2, Phase 3 20, Phase 2/3 1, Phase 2 75, Phase 1/2 26, Phase 1 49) 2011: 293 trials (Observational 57, Not applicable 52, Phase 4 6, Phase 3 27, Phase 2/3 8, Phase 2 78, Phase 1/2 19, Phase 1 46) 2012: 314 trials (Other 1, Observational 86, Not applicable 53, Phase 4 3, Phase 3 18, Phase 2/3 2, Phase 2 90, Phase 1/2 24, Phase 1 37) 2013: 330 trials (Observational 74, Not applicable 54, Phase 4 5, Phase 3 27, Phase 2/3 4, Phase 2 97, Phase 1/2 17, Phase 1 52) 2014: 345 trials (Observational 76, Not applicable 66, Phase 4 8, Phase 3 28, Phase 2/3 6, Phase 2 76, Phase 1/2 26, Phase 1 59) 2015: 475 trials (Observational 92, Not applicable 86, Phase 4 7, Phase 3 37, Phase 2/3 8, Phase 2 114, Phase 1/2 51, Phase 1 80) 2016: 515 trials (Observational 118, Not applicable 92, Phase 4 6, Phase 3 43, Phase 2/3 2, Phase 2 111, Phase 1/2 49, Phase 1 94) 2017: 526 trials (Observational 119, Not applicable 87, Phase 4 10, Phase 3 30, Phase 2/3 6, Phase 2 121, Phase 1/2 65, Phase 1 88) 2018: 581 trials (Observational 123, Not applicable 121, Phase 4 7, Phase 3 46, Phase 2/3 6, Phase 2 134, Phase 1/2 53, Phase 1 91) 2019: 558 trials (Observational 136, Not applicable 93, Phase 4 14, Phase 3 38, Phase 2/3 3, Phase 2 129, Phase 1/2 47, Phase 1 98) 2020: 621 trials (Observational 164, Not applicable 88, Phase 4 6, Phase 3 48, Phase 2/3 5, Phase 2 165, Phase 1/2 53, Phase 1 92) 2021: 734 trials (Observational 174, Not applicable 136, Phase 4 7, Phase 3 51, Phase 2/3 3, Phase 2 179, Phase 1/2 73, Phase 1 111) 2022: 675 trials (Observational 152, Not applicable 135, Phase 4 7, Phase 3 35, Phase 2/3 5, Phase 2 172, Phase 1/2 68, Phase 1 101) 2023: 704 trials (Observational 182, Not applicable 158, Phase 4 6, Phase 3 47, Phase 2/3 5, Phase 2 141, Phase 1/2 67, Phase 1 98) 2024: 793 trials (Observational 182, Not applicable 167, Phase 4 11, Phase 3 64, Phase 2/3 5, Phase 2 182, Phase 1/2 55, Phase 1 127) 2025: 736 trials (Observational 172, Not applicable 131, Phase 4 3, Phase 3 64, Phase 2/3 11, Phase 2 183, Phase 1/2 61, Phase 1 111)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 711
2025 736
2024 793
2023 704
2022 675
2021 734
2020 621
2019 558
2018 581
2017 526

Forecast of the full-year count, planned starts included, not rows of this table: about 880 trials starting in 2026 and about 780 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 10 percent and ran about 4 percent high against the count later registered; forecasts made before the year began were off by about 25 percent and ran about 15 percent low against the count later registered, and had about 7 percent more error than repeating last year's count. The part-way figures are from forecasts that used a multiple fitted only on earlier years. A stricter check that trains only on older years did not support adding planned starts for conditions of this size: it ran about 6 percent high against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 1,599 trials still running at the 2026-10-09 snapshot; registered median of 34 months across 6,231 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Lung Neoplasms trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1,805
Phase 1/2 998
Phase 2 3,238
Phase 2/3 119
Phase 3 989
Phase 4 158
Not applicable 1,930
Observational 2,420
Expanded access 45
Unknown 1

How many Lung Neoplasms trials are recruiting? (13)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 628
Recruiting 1,878
Enrolling by invitation 53
Active, not recruiting 829
Available 10

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Lung Neoplasms trials? (9)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 309
AstraZeneca 233
Eli Lilly and Company 159
Pfizer 139
Bristol-Myers Squibb 110

Which drugs are being tested for Lung Neoplasms? (5)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
PEMBROLIZUMAB 484
(nab)-paclitaxel 463
NIVOLUMAB 252
DURVALUMAB 211
Osimertinib 186

Interventions as named in the registry (10)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
or carboplatin 811
Cisplatin 1 562
Pemetrexe 491
Docetetaxel 393
Gemcitabine/Gemzar 298

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Lung Neoplasms trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 9,142 733
Malignant neoplasm progression 6,090 151
Dyspnoea 4,613 560
Febrile neutropenia 3,226 431
Anaemia 2,815 459

Which publications cover Lung Neoplasms? (8,765)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
VALUE Trial: Phase 1 safety and feasibility study of same-day discharge after video-assisted thoracoscopic surgery lung resection. The Journal of thoracic and cardiovascular surgery 2026 Yes
Long-Term Safety and Effectiveness of Durvalumab in Unresectable Stage III NSCLC in Japan: A Multicenter Prospective Study (AYAME). Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2026 Yes
TROPION-Lung12: A phase 3 study of adjuvant datopotamab deruxtecan and rilvegostomig in ctDNA-positive or high-risk pathology stage I non-small cell lung cancer. The Journal of thoracic and cardiovascular surgery 2026 Yes
Active Surveillance of Multifocal Ground-Glass Opacities: Results of a Prospective Multicenter Trial (ECTOP1021). Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2026 Yes
Derivation of Meaningful Change Thresholds for European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-LC13 in Patients With Small-Cell Lung Cancer. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2026 Yes

Sub-conditions in MeSH (8)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages