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Condition (MeSH)

Respiratory Tract Neoplasms

ClinicalTrials.gov lists 12,067 trials for Respiratory Tract Neoplasms or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 326.

MeSH D012142 Neoplasms Neoplasm C04 C08
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Phase 1 Phase 1 1,850 Phase 1/2 Phase 1/2 1,011 Phase 2 Phase 2 3,322 Phase 2/3 Phase 2/3 125 Phase 3 Phase 3 1,014 Phase 4 Phase 4 166 Not applicable Not applicable 2,025 Observational Observational 2,508 Phase 1 Phase 1 1,850 Phase 1/2 Phase 1/2 1,011 Phase 2 Phase 2 3,322 Phase 2/3 Phase 2/3 125 Phase 3 Phase 3 1,014 Phase 4 Phase 4 166 Not applicable Not applicable 2,025 Observational Observational 2,508

Trials per phase (log scale)

2 more sections with rows

60 of the 12,067 trials are tagged with Respiratory Tract Neoplasms itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Respiratory Tract Neoplasms trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 24 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access, Unknown)

Top of scale: 816

1990: 2 trials (Not applicable 1, Phase 2 1) 1991: 2 trials (Phase 2 1, Phase 1 1) 1992: 3 trials (Observational 2, Phase 2 1) 1993: 10 trials (Observational 2, Not applicable 1, Phase 3 2, Phase 2 3, Phase 1 2) 1994: 10 trials (Not applicable 1, Phase 3 6, Phase 2 2, Phase 1 1) 1995: 16 trials (Observational 2, Not applicable 1, Phase 3 4, Phase 2 4, Phase 1/2 1, Phase 1 4) 1996: 27 trials (Observational 3, Not applicable 1, Phase 3 4, Phase 2/3 2, Phase 2 12, Phase 1/2 1, Phase 1 4) 1997: 33 trials (Observational 2, Phase 3 7, Phase 2 11, Phase 1/2 6, Phase 1 7) 1998: 62 trials (Observational 6, Not applicable 2, Phase 3 18, Phase 2 24, Phase 1/2 3, Phase 1 9) 1999: 74 trials (Observational 3, Not applicable 3, Phase 3 18, Phase 2 29, Phase 1/2 3, Phase 1 18) 2000: 102 trials (Observational 10, Not applicable 3, Phase 4 1, Phase 3 19, Phase 2/3 2, Phase 2 40, Phase 1/2 6, Phase 1 21) 2001: 100 trials (Observational 8, Not applicable 6, Phase 3 23, Phase 2/3 4, Phase 2 40, Phase 1/2 7, Phase 1 12) 2002: 133 trials (Observational 13, Not applicable 5, Phase 4 3, Phase 3 23, Phase 2/3 3, Phase 2 64, Phase 1/2 6, Phase 1 16) 2003: 167 trials (Observational 20, Not applicable 8, Phase 4 1, Phase 3 15, Phase 2 82, Phase 1/2 17, Phase 1 24) 2004: 200 trials (Observational 24, Not applicable 20, Phase 4 2, Phase 3 20, Phase 2/3 1, Phase 2 88, Phase 1/2 14, Phase 1 31) 2005: 230 trials (Observational 41, Not applicable 13, Phase 4 1, Phase 3 24, Phase 2/3 5, Phase 2 105, Phase 1/2 12, Phase 1 29) 2006: 301 trials (Observational 35, Not applicable 27, Phase 4 4, Phase 3 37, Phase 2/3 3, Phase 2 140, Phase 1/2 20, Phase 1 35) 2007: 303 trials (Other 1, Observational 42, Not applicable 21, Phase 4 6, Phase 3 34, Phase 2/3 5, Phase 2 116, Phase 1/2 22, Phase 1 56) 2008: 338 trials (Observational 52, Not applicable 31, Phase 4 11, Phase 3 37, Phase 2/3 2, Phase 2 124, Phase 1/2 32, Phase 1 49) 2009: 360 trials (Observational 61, Not applicable 45, Phase 4 8, Phase 3 33, Phase 2/3 4, Phase 2 118, Phase 1/2 20, Phase 1 71) 2010: 299 trials (Observational 78, Not applicable 42, Phase 4 3, Phase 3 20, Phase 2/3 1, Phase 2 80, Phase 1/2 26, Phase 1 49) 2011: 302 trials (Observational 59, Not applicable 54, Phase 4 6, Phase 3 28, Phase 2/3 8, Phase 2 82, Phase 1/2 19, Phase 1 46) 2012: 322 trials (Other 1, Observational 89, Not applicable 56, Phase 4 3, Phase 3 18, Phase 2/3 2, Phase 2 92, Phase 1/2 24, Phase 1 37) 2013: 336 trials (Observational 76, Not applicable 55, Phase 4 5, Phase 3 27, Phase 2/3 4, Phase 2 99, Phase 1/2 17, Phase 1 53) 2014: 354 trials (Observational 78, Not applicable 69, Phase 4 8, Phase 3 29, Phase 2/3 6, Phase 2 76, Phase 1/2 26, Phase 1 62) 2015: 490 trials (Observational 93, Not applicable 93, Phase 4 7, Phase 3 38, Phase 2/3 8, Phase 2 118, Phase 1/2 51, Phase 1 82) 2016: 539 trials (Observational 127, Not applicable 99, Phase 4 7, Phase 3 44, Phase 2/3 2, Phase 2 115, Phase 1/2 50, Phase 1 95) 2017: 541 trials (Observational 124, Not applicable 92, Phase 4 10, Phase 3 30, Phase 2/3 6, Phase 2 125, Phase 1/2 65, Phase 1 89) 2018: 598 trials (Observational 129, Not applicable 128, Phase 4 8, Phase 3 46, Phase 2/3 7, Phase 2 136, Phase 1/2 53, Phase 1 91) 2019: 571 trials (Observational 136, Not applicable 98, Phase 4 14, Phase 3 38, Phase 2/3 4, Phase 2 131, Phase 1/2 50, Phase 1 100) 2020: 633 trials (Observational 168, Not applicable 91, Phase 4 6, Phase 3 48, Phase 2/3 5, Phase 2 167, Phase 1/2 53, Phase 1 95) 2021: 755 trials (Observational 182, Not applicable 140, Phase 4 8, Phase 3 52, Phase 2/3 3, Phase 2 184, Phase 1/2 73, Phase 1 113) 2022: 697 trials (Observational 160, Not applicable 140, Phase 4 7, Phase 3 36, Phase 2/3 5, Phase 2 176, Phase 1/2 69, Phase 1 104) 2023: 730 trials (Observational 191, Not applicable 166, Phase 4 6, Phase 3 48, Phase 2/3 6, Phase 2 143, Phase 1/2 67, Phase 1 103) 2024: 816 trials (Observational 186, Not applicable 175, Phase 4 12, Phase 3 64, Phase 2/3 6, Phase 2 187, Phase 1/2 55, Phase 1 131) 2025: 754 trials (Observational 175, Not applicable 137, Phase 4 3, Phase 3 67, Phase 2/3 11, Phase 2 187, Phase 1/2 61, Phase 1 113)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 734
2025 754
2024 816
2023 730
2022 697
2021 755
2020 633
2019 571
2018 598
2017 541

Forecast of the full-year count, planned starts included, not rows of this table: about 910 trials starting in 2026 and about 800 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 10 percent and ran about 4 percent high against the count later registered; forecasts made before the year began were off by about 25 percent and ran about 15 percent low against the count later registered, and had about 7 percent more error than repeating last year's count. The part-way figures are from forecasts that used a multiple fitted only on earlier years. A stricter check that trains only on older years did not support adding planned starts for conditions of this size: it ran about 6 percent high against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 1,640 trials still running at the 2026-10-09 snapshot; registered median of 34 months across 6,407 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Respiratory Tract Neoplasms trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1,850
Phase 1/2 1,011
Phase 2 3,322
Phase 2/3 125
Phase 3 1,014
Phase 4 166
Not applicable 2,025
Observational 2,508
Expanded access 45
Unknown 1

How many Respiratory Tract Neoplasms trials are recruiting? (13)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 651
Recruiting 1,931
Enrolling by invitation 55
Active, not recruiting 847
Available 10

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Respiratory Tract Neoplasms trials? (8)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 326
AstraZeneca 233
Eli Lilly and Company 160
Pfizer 139
Bristol-Myers Squibb 110

Which drugs are being tested for Respiratory Tract Neoplasms? (5)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
PEMBROLIZUMAB 496
(nab)-paclitaxel 472
NIVOLUMAB 255
DURVALUMAB 213
Osimertinib 186

Interventions as named in the registry (10)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
or carboplatin 825
Cisplatin 1 603
Pemetrexe 492
Docetetaxel 404
Gemcitabine/Gemzar 300

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Respiratory Tract Neoplasms trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 9,185 738
Malignant neoplasm progression 6,090 151
Dyspnoea 4,613 560
Febrile neutropenia 3,252 439
Vomiting 2,829 669

Which publications cover Respiratory Tract Neoplasms? (24)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages