Organization (Hospital)
Massachusetts Eye and Ear Infirmary
ClinicalTrials.gov lists Massachusetts Eye and Ear Infirmary as lead sponsor of 100 trials. It has 62 active development programs and 33 approved assets.
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Trials started per year with this organization as sponsor or collaborator, 1990 onward. The series also counts trials where the organization is a collaborator; the lead-sponsor trial count does not.
2026 is partial: 10 registered with a 2026 start date. The hollow diamonds on the dashed line are a forecast of the full-year count, planned starts included: about 11 in 2026 and about 8 in 2027, the average of the 24 months through September, counted as registered and carried forward. The columns, the lighter one included, count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. This method has not been backtested on organizations. In backtests on conditions with as many trial starts a year as this organization (5 to 20), forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored. 1 trial is registered to start in 2027 or later.
This page covers Massachusetts Eye and Ear Infirmary: 100 lead-sponsored trials and 2 legal-entity registrations.
Disease areas (142)
Shown in this order: most trials first.
| Disease area | Trials |
|---|---|
| Vision Disorders | 12 |
| Glaucoma | 11 |
| Hearing Loss | 11 |
| Blindness | 8 |
| Laryngeal Diseases | 8 |
Showing 5 of 142 disease areas.
Trials by start year as sponsor or collaborator (24)
Shown in this order: most recent first. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Show the table of trials by start year as sponsor or collaborator
| Year | Trials started |
|---|---|
| 2026 (partial year) | 10 |
| 2025 | 8 |
| 2024 | 5 |
| 2023 | 4 |
| 2022 | 11 |
| 2021 | 11 |
| 2020 | 6 |
| 2019 | 7 |
| 2018 | 7 |
| 2017 | 2 |
Showing 10 of 24 years.
Prediction, not a registry value: median of 36 months from start to primary completion across 12 trials still running at the 2026-10-09 snapshot; registered median of 34 months across 59 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
Active development programs (62)
Shown in this order: max phase, then active trials.
| Drug | Disease area | Max phase | Trials |
|---|---|---|---|
| Artificial Tears | Trichiasis | Phase 3 | 1 |
| Fluorometholone 0.1% Oph Susp | Trichiasis | Phase 3 | 1 |
| Atorvastatin 80mg | Macular Degeneration | Phase 2 | 1 |
| N-acetyl cysteine (NAC) 20% solution | Corneal Dystrophies, Hereditary | Phase 2 | 1 |
| N-acetyl cysteine (NAC) 20% solution | Fuchs' Endothelial Dystrophy | Phase 2 | 1 |
Showing 5 of 62 active programs.
Approved assets (33)
Shown in this order: max phase first.
| Drug | Trials |
|---|---|
| DEXTENZA (dexamethasone ophthalmic insert) 0.4 mg, for intracanalicular use | 1 |
| Arificial Tear | 1 |
| OPTI-FREE® RepleniSH® | 1 |
| Amoxicillin + Clavulanate | 1 |
| Atropine 1% | 1 |
Showing 5 of 33 approved assets.
Sponsor delivery record (1)
Enrollment hit target: the share of this sponsor's lead-sponsored trials whose actual enrollment reached the planned enrollment. On time: the share whose actual primary completion date was no later than the planned date. Each share counts only trials where we observed an estimated figure before the actual one, and n is that number of trials. Below 5 trials the count is shown as a fraction, not a percentage.
| Enrollment | Timeline |
|---|---|
| 22% hit target (n=36) | 32% on time (n=31) |
Journals published in (244)
Shown in this order: most published in first.
| Journal | Publications |
|---|---|
| American journal of ophthalmology | 13 |
| Investigative ophthalmology & visual science | 12 |
| Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery | 12 |
| The Laryngoscope | 10 |
| Translational vision science & technology | 10 |
Showing 5 of 244 journals.
US granted patents (1)
Patents are not classified by disease area in the source, so this is the organization's overall portfolio, not a split by disease.
| US patents granted | Granted in the last 5 years | Most recent grant |
|---|---|---|
| 267 | 65 | 2025-12-23 |
Financing and grant events (360)
Shown in this order: most recent first.
| Date | Round type | Amount (USD) | Source |
|---|---|---|---|
| 2025-09-22 | NIH grant | 570,177 | Reporter |
| 2025-09-22 | NIH grant | 223,756 | Reporter |
| 2025-09-22 | NIH grant | 592,959 | Reporter |
| 2025-09-19 | NIH grant | 361,250 | Reporter |
| 2025-09-19 | NIH grant | 361,250 | Reporter |
Showing 5 of 360 events.
FDA inspection record (1)
| Latest classification | Inspections |
|---|---|
| NAI | 2 |
Organization relationships (18)
Shown in this order: most evidence first.
| Related organization | Relationship | Evidence |
|---|---|---|
| Government of the United States of America | Co sponsors trial with | 2 |
| University of California System | Co sponsors trial with | 1 |
| BioElectronics (United States) | Co sponsors trial with | 1 |
| Radboud University Medical Center | Co sponsors trial with | 1 |
| Roche (Switzerland) | Co sponsors trial with | 1 |
Showing 5 of 18 relationships.
Latest dated events (754)
Shown in this order: newest first.
| Date | Event | Source |
|---|---|---|
| 2027-09 | Trial started | Clinical trials (ClinicalTrials.gov) (ClinicalTrials.gov, U.S. National Library of Medicine; AACT database, Clinical Trials Transformation Initiative (CTTI)) |
| 2026-10-01 | Trial started | Clinical trials (ClinicalTrials.gov) (ClinicalTrials.gov, U.S. National Library of Medicine; AACT database, Clinical Trials Transformation Initiative (CTTI)) |
| 2026-09-25 | Trial started | Clinical trials (ClinicalTrials.gov) (ClinicalTrials.gov, U.S. National Library of Medicine; AACT database, Clinical Trials Transformation Initiative (CTTI)) |
| 2026-09-15 | Trial started | Clinical trials (ClinicalTrials.gov) (ClinicalTrials.gov, U.S. National Library of Medicine; AACT database, Clinical Trials Transformation Initiative (CTTI)) |
| 2026-09-15 | Trial started | Clinical trials (ClinicalTrials.gov) (ClinicalTrials.gov, U.S. National Library of Medicine; AACT database, Clinical Trials Transformation Initiative (CTTI)) |
Showing 5 of 754 events.
Biomarker capability evidence (76)
Shown in this order: tier desc, then gene symbol.
| Gene | Role | Evidence |
|---|---|---|
| AATF | Trial collaborator | Named in trial inclusion criteria |
| BCAR1 | Trial sponsor | Named in trial inclusion criteria |
| CSE1L | Trial sponsor | Named in trial inclusion criteria |
| IL1RN | Trial sponsor | Named in trial inclusion criteria |
| MYCBP2 | Trial sponsor | Named in trial inclusion criteria |
Showing 5 of 76 evidence rows.
Biomarkers this organization publishes on (358)
Shown in this order: most publications first.
Showing 5 of 358 biomarkers.
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