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Condition (MeSH)

Hearing Loss

ClinicalTrials.gov lists 1,357 trials for Hearing Loss or a narrower condition beneath it. Cochlear has the most among industry and government lead sponsors, with 83.

MeSH D034381 Otorhinolaryngologic Diseases C09 C10 C23
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Phase 1 Phase 1 36 Phase 1/2 Phase 1/2 36 Phase 2 Phase 2 59 Phase 2/3 Phase 2/3 13 Phase 3 Phase 3 22 Phase 4 Phase 4 17 Not applicable Not applicable 801 Observational Observational 365 Phase 1 Phase 1 36 Phase 1/2 Phase 1/2 36 Phase 2 Phase 2 59 Phase 2/3 Phase 2/3 13 Phase 3 Phase 3 22 Phase 4 Phase 4 17 Not applicable Not applicable 801 Observational Observational 365

Trials per phase (log scale)

2 more sections with rows

762 of the 1,357 trials are tagged with Hearing Loss itself; the rest are tagged with a narrower condition beneath it.

Get the Hearing Loss report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Hearing Loss trials start? (32)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 10 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Unknown)

Top of scale: 113

1991: 1 trials (Observational 1) 1993: 1 trials (Observational 1) 1997: 2 trials (Observational 2) 1998: 3 trials (Observational 2, Phase 3 1) 1999: 5 trials (Observational 3, Phase 2 2) 2000: 5 trials (Observational 3, Not applicable 1, Phase 2 1) 2001: 5 trials (Observational 3, Not applicable 1, Phase 2 1) 2002: 1 trials (Observational 1) 2003: 3 trials (Not applicable 1, Phase 3 1, Phase 2 1) 2004: 6 trials (Observational 2, Not applicable 2, Phase 4 1, Phase 3 1) 2005: 6 trials (Observational 5, Not applicable 1) 2006: 16 trials (Observational 4, Not applicable 4, Phase 4 2, Phase 2/3 2, Phase 2 1, Phase 1 3) 2007: 19 trials (Observational 4, Not applicable 10, Phase 4 1, Phase 2/3 1, Phase 2 3) 2008: 14 trials (Observational 1, Not applicable 7, Phase 4 1, Phase 2 3, Phase 1/2 1, Phase 1 1) 2009: 16 trials (Observational 7, Not applicable 8, Phase 1 1) 2010: 20 trials (Observational 8, Not applicable 7, Phase 4 2, Phase 2/3 1, Phase 1 2) 2011: 32 trials (Observational 10, Not applicable 11, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 4) 2012: 29 trials (Observational 3, Not applicable 19, Phase 3 2, Phase 2 1, Phase 1/2 3, Phase 1 1) 2013: 40 trials (Observational 5, Not applicable 25, Phase 4 1, Phase 3 2, Phase 2 4, Phase 1/2 2, Phase 1 1) 2014: 43 trials (Observational 10, Not applicable 29, Phase 2 1, Phase 1/2 1, Phase 1 2) 2015: 44 trials (Other 1, Observational 5, Not applicable 33, Phase 3 1, Phase 2 2, Phase 1/2 2) 2016: 48 trials (Other 1, Observational 7, Not applicable 35, Phase 3 1, Phase 2/3 2, Phase 2 1, Phase 1 1) 2017: 71 trials (Other 1, Observational 24, Not applicable 38, Phase 3 1, Phase 2 3, Phase 1/2 2, Phase 1 2) 2018: 87 trials (Observational 23, Not applicable 58, Phase 4 2, Phase 2 2, Phase 1/2 2) 2019: 99 trials (Other 1, Observational 36, Not applicable 54, Phase 4 2, Phase 2/3 1, Phase 2 2, Phase 1/2 2, Phase 1 1) 2020: 85 trials (Observational 24, Not applicable 53, Phase 1/2 3, Phase 1 5) 2021: 111 trials (Other 1, Observational 27, Not applicable 73, Phase 2/3 2, Phase 2 5, Phase 1/2 1, Phase 1 2) 2022: 112 trials (Observational 22, Not applicable 81, Phase 3 1, Phase 2 5, Phase 1 3) 2023: 105 trials (Observational 25, Not applicable 67, Phase 4 1, Phase 3 4, Phase 2/3 1, Phase 2 3, Phase 1/2 1, Phase 1 3) 2024: 99 trials (Other 1, Observational 30, Not applicable 55, Phase 4 1, Phase 2/3 1, Phase 2 5, Phase 1/2 4, Phase 1 2) 2025: 113 trials (Other 1, Observational 32, Not applicable 69, Phase 4 2, Phase 3 2, Phase 2/3 1, Phase 2 3, Phase 1/2 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 99
2025 113
2024 99
2023 105
2022 112
2021 111
2020 85
2019 99
2018 87
2017 71

Forecast of the full-year count, planned starts included, not rows of this table: about 110 trials starting in 2026 and about 110 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 142 trials still running at the 2026-10-09 snapshot; registered median of 15 months across 768 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Hearing Loss trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 36
Phase 1/2 36
Phase 2 59
Phase 2/3 13
Phase 3 22
Phase 4 17
Not applicable 801
Observational 365
Expanded access 1
Unknown 7

How many Hearing Loss trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 98
Recruiting 187
Enrolling by invitation 24
Active, not recruiting 37
Available 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Hearing Loss trials? (8)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Cochlear 83
Sonova AG 80
Oticon Medical 42
MED-EL Elektromedizinische Geräte GesmbH 24
US Department of Veterans Affairs 18

Which drugs are being tested for Hearing Loss? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
METHYLPREDNISOLONE 8
Ebselen 7
Prednisone 4
Sodium Thiosulfate 3

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Dexamethasone/Dexamethasone acetate 12
N Acetylcysteine 8
FX-322 6
Valganciclovir 4
Low dose zonisamide 3

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Hearing Loss trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Loss of residual hearing 21 1
Postoperative decrease/loss of residual hearing 10 1
Profound/total loss of residual hearing 8 1
Loss of Residual Hearing 7 1
Death or terminal illness 6 1

Which publications cover Hearing Loss? (608)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Changes in participatory and societal outcomes during the waiting period for cochlear implantation - an observational study. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2025 Yes
Hearing and cognitive scores measured with the Montreal Cognitive Assessment Scale in The HUNT Study, Norway. Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Yes
Effects on health outcomes following a nurse-led hearing loss management intervention designed for older adults: A randomized controlled trial. International journal of nursing studies 2025 Yes
Awareness about the risk of hearing loss after ototoxic treatments in Swiss childhood cancer survivors. Patient education and counseling 2025 Yes
Hearing Intervention, Social Isolation, and Loneliness: A Secondary Analysis of the ACHIEVE Randomized Clinical Trial. JAMA internal medicine 2025 Yes

Sub-conditions in MeSH (10)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages