A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors

Title

A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors

Lead sponsor

National Cancer Institute (NCI)

Phase

Phase 1

Overall status

Completed

Start date

February 28, 2010

Completion date

-Not reported

Enrollment

27 (actual)

Sites

9

childhood atypical teratoid/rhabdoid tumor, childhood central nervous system choriocarcinoma, childhood central nervous system embryonal tumor, childhood central nervous system germinoma, childhood central nervous system mixed germ cell tumor, childhood central nervous system teratoma, childhood central nervous system yolk sac tumor, childhood choroid plexus tumor, childhood craniopharyngioma, childhood ependymoblastoma, childhood grade i meningioma, childhood grade ii meningioma, childhood grade iii meningioma, childhood high-grade cerebellar astrocytoma, childhood high-grade cerebral astrocytoma, childhood infratentorial ependymoma, childhood low-grade cerebellar astrocytoma, childhood low-grade cerebral astrocytoma, childhood medulloepithelioma, childhood mixed glioma, childhood oligodendroglioma, childhood supratentorial ependymoma, extra-adrenal paraganglioma, recurrent childhood brain stem glioma, recurrent childhood central nervous system embryonal tumor, recurrent childhood cerebellar astrocytoma, recurrent childhood cerebral astrocytoma, recurrent childhood ependymoma, recurrent childhood medulloblastoma, recurrent childhood pineoblastoma, recurrent childhood spinal cord neoplasm, recurrent childhood subependymal giant cell astrocytoma, recurrent childhood supratentorial primitive neuroectodermal tumor, recurrent childhood visual pathway and hypothalamic glioma