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Clinical trial

Phase I Study of the Aurora Kinase a Inhibitor MLN8237 in Combination With the Histone Deacetylase Inhibitor Vorinostat in Lymphoid Malignancies

NCT01567709 is registered in ClinicalTrials.gov with National Cancer Institute (NCI) as lead sponsor.

NCT NCT01567709
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Registry record

As filed in ClinicalTrials.gov.

Title
Phase I Study of the Aurora Kinase a Inhibitor MLN8237 in Combination With the Histone Deacetylase Inhibitor Vorinostat in Lymphoid Malignancies
Lead sponsor
National Cancer Institute (NCI)
Phase
Phase 1
Overall status
Completed
Start date
April 16, 2012
Completion date
March 29, 2018
Enrollment
34 (actual)
Sites
5

Conditions

As the registry lists them; a condition with its own page is linked.

adult b acute lymphoblastic leukemia, adult t acute lymphoblastic leukemia, anaplastic large cell lymphoma, angioimmunoblastic t-cell lymphoma, chronic lymphocytic leukemia, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, hepatosplenic t-cell lymphoma, intraocular lymphoma, lymphomatous involvement of non-cutaneous extranodal site, mature t-cell and nk-cell non-hodgkin lymphoma, nodal marginal zone lymphoma, primary cutaneous b-cell non-hodgkin lymphoma, recurrent adult acute lymphoblastic leukemia, recurrent adult burkitt lymphoma, recurrent adult grade iii lymphomatoid granulomatosis, recurrent adult hodgkin lymphoma, recurrent adult immunoblastic lymphoma, recurrent adult lymphoblastic lymphoma, recurrent adult t-cell leukemia/lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, recurrent mantle cell lymphoma, recurrent marginal zone lymphoma, recurrent mycosis fungoides and sezary syndrome, recurrent non-hodgkin lymphoma, recurrent primary cutaneous t-cell non-hodgkin lymphoma, recurrent small lymphocytic lymphoma, refractory chronic lymphocytic leukemia, refractory hairy cell leukemia, small intestinal lymphoma, splenic marginal zone lymphoma, t-cell large granular lymphocyte leukemia, testicular lymphoma, waldenstrom macroglobulinemia