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Clinical trial

A Phase II/III Trial of Chemotherapy + Cetuximab vs Chemotherapy + Bevacizumab vs Atezolizumab + Bevacizumab Following Progression on Immune Checkpoint Inhibition in Recurrent/Metastatic Head and Neck Cancers

NCT05063552 is registered in ClinicalTrials.gov with National Cancer Institute (NCI) as lead sponsor.

NCT NCT05063552
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Registry record

As filed in ClinicalTrials.gov.

Title
A Phase II/III Trial of Chemotherapy + Cetuximab vs Chemotherapy + Bevacizumab vs Atezolizumab + Bevacizumab Following Progression on Immune Checkpoint Inhibition in Recurrent/Metastatic Head and Neck Cancers
Lead sponsor
National Cancer Institute (NCI)
Phase
Phase 2/3
Overall status
Active, not recruiting
Start date
March 13, 2023
Completion date
December 15, 2027
Enrollment
430 (estimated)
Sites
172

Conditions

As the registry lists them; a condition with its own page is linked.

clinical stage iv hpv-mediated (p16-positive) oropharyngeal carcinoma ajcc v8, metastatic head and neck squamous cell carcinoma, metastatic hypopharyngeal squamous cell carcinoma, metastatic laryngeal squamous cell carcinoma, metastatic lip and oral cavity carcinoma, metastatic nasal cavity squamous cell carcinoma, metastatic nasopharyngeal squamous cell carcinoma, metastatic pharyngeal squamous cell carcinoma, metastatic sinonasal squamous cell carcinoma, recurrent head and neck squamous cell carcinoma, recurrent hypopharyngeal squamous cell carcinoma, recurrent laryngeal squamous cell carcinoma, recurrent lip and oral cavity squamous cell carcinoma, recurrent nasopharyngeal squamous cell carcinoma, recurrent pharyngeal squamous cell carcinoma, recurrent sinonasal squamous cell carcinoma, stage iv head and neck cutaneous squamous cell carcinoma ajcc v8, stage iv hypopharyngeal carcinoma ajcc v8, stage iv laryngeal cancer ajcc v8, stage iv lip and oral cavity cancer ajcc v8, stage iv nasopharyngeal carcinoma ajcc v8, stage iv oropharyngeal (p16-negative) carcinoma ajcc v8, stage iv sinonasal cancer ajcc v8