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Condition (MeSH)

Oropharyngeal Neoplasms

ClinicalTrials.gov lists 372 trials for Oropharyngeal Neoplasms or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 28.

MeSH D009959 Neoplasms Neoplasm C04 C07 C09
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Phase 1 Phase 1 35 Phase 1/2 Phase 1/2 24 Phase 2 Phase 2 105 Phase 2/3 Phase 2/3 9 Phase 3 Phase 3 26 Phase 4 Phase 4 5 Not applicable Not applicable 92 Observational Observational 76 Phase 1 Phase 1 35 Phase 1/2 Phase 1/2 24 Phase 2 Phase 2 105 Phase 2/3 Phase 2/3 9 Phase 3 Phase 3 26 Phase 4 Phase 4 5 Not applicable Not applicable 92 Observational Observational 76

Trials per phase (log scale)

367 of the 372 trials are tagged with Oropharyngeal Neoplasms itself; the rest are tagged with a narrower condition beneath it.

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When did Oropharyngeal Neoplasms trials start? (32)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 28

1995: 1 trials (Phase 2 1) 1996: 4 trials (Not applicable 1, Phase 2/3 1, Phase 2 2) 1997: 3 trials (Phase 2 1, Phase 1/2 2) 1998: 2 trials (Phase 2 1, Phase 1 1) 1999: 5 trials (Not applicable 1, Phase 2 1, Phase 1 3) 2000: 3 trials (Phase 3 3) 2001: 3 trials (Observational 1, Not applicable 1, Phase 1 1) 2002: 3 trials (Observational 1, Phase 2 1, Phase 1 1) 2003: 3 trials (Phase 2 2, Phase 1/2 1) 2004: 1 trials (Phase 3 1) 2005: 5 trials (Observational 1, Not applicable 1, Phase 3 1, Phase 2 1, Phase 1 1) 2006: 8 trials (Observational 1, Not applicable 3, Phase 4 1, Phase 3 1, Phase 2 1, Phase 1 1) 2007: 13 trials (Observational 7, Not applicable 2, Phase 4 1, Phase 2 2, Phase 1/2 1) 2008: 8 trials (Observational 2, Not applicable 3, Phase 2/3 1, Phase 2 2) 2009: 7 trials (Observational 2, Not applicable 1, Phase 3 2, Phase 1/2 1, Phase 1 1) 2010: 10 trials (Observational 2, Not applicable 3, Phase 2 3, Phase 1 2) 2011: 7 trials (Not applicable 2, Phase 3 1, Phase 2/3 1, Phase 2 3) 2012: 10 trials (Not applicable 4, Phase 2 5, Phase 1/2 1) 2013: 11 trials (Observational 4, Not applicable 3, Phase 3 2, Phase 1/2 1, Phase 1 1) 2014: 10 trials (Observational 1, Not applicable 4, Phase 2 4, Phase 1/2 1) 2015: 11 trials (Observational 5, Not applicable 3, Phase 3 1, Phase 2 1, Phase 1 1) 2016: 18 trials (Observational 5, Not applicable 6, Phase 3 2, Phase 2 4, Phase 1/2 1) 2017: 17 trials (Observational 4, Not applicable 5, Phase 3 1, Phase 2 5, Phase 1/2 1, Phase 1 1) 2018: 27 trials (Observational 4, Not applicable 9, Phase 4 1, Phase 2/3 1, Phase 2 10, Phase 1/2 2) 2019: 27 trials (Observational 3, Not applicable 9, Phase 3 2, Phase 2/3 1, Phase 2 6, Phase 1/2 3, Phase 1 3) 2020: 19 trials (Observational 6, Not applicable 3, Phase 3 2, Phase 2 4, Phase 1/2 2, Phase 1 2) 2021: 23 trials (Observational 5, Not applicable 7, Phase 2/3 1, Phase 2 7, Phase 1/2 1, Phase 1 2) 2022: 24 trials (Observational 7, Not applicable 3, Phase 3 1, Phase 2/3 1, Phase 2 9, Phase 1/2 1, Phase 1 2) 2023: 28 trials (Observational 6, Not applicable 7, Phase 3 2, Phase 2/3 1, Phase 2 9, Phase 1/2 1, Phase 1 2) 2024: 17 trials (Observational 6, Not applicable 1, Phase 2/3 1, Phase 2 6, Phase 1/2 2, Phase 1 1) 2025: 26 trials (Observational 1, Not applicable 7, Phase 4 1, Phase 3 1, Phase 2 10, Phase 1/2 1, Phase 1 5)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 15
2025 26
2024 17
2023 28
2022 24
2021 23
2020 19
2019 27
2018 27
2017 17

Forecast of the full-year count, planned starts included, not rows of this table: about 20 trials starting in 2026 and about 23 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 59 trials still running at the 2026-10-09 snapshot; registered median of 42 months across 193 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Oropharyngeal Neoplasms trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 35
Phase 1/2 24
Phase 2 105
Phase 2/3 9
Phase 3 26
Phase 4 5
Not applicable 92
Observational 76

How many Oropharyngeal Neoplasms trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 13
Recruiting 80
Enrolling by invitation 1
Active, not recruiting 47
Completed 139

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Oropharyngeal Neoplasms trials? (1)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 28

Which drugs are being tested for Oropharyngeal Neoplasms? (5)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
PEMBROLIZUMAB 15
CETUXIMAB 13
(nab)-paclitaxel 11
NIVOLUMAB 7
DURVALUMAB 6

Interventions as named in the registry (10)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Cisplatin 1 46
Radiation Therapy 24
Positron Emission Tomography (PET) 18
or carboplatin 15
Radiotherapy 10

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Oropharyngeal Neoplasms trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Dysphagia 141 13
Mucositis oral 110 7
Lymphocyte count decreased 81 4
Nausea 69 11
Dehydration 59 12

Which publications cover Oropharyngeal Neoplasms? (347)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages