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Clinical trial

A First-in-human Phase 1 Dose-escalation Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of KST-6051 in Patients With Advanced or Metastatic Solid Tumors With a KRAS Mutation

NCT07458347 is registered in ClinicalTrials.gov with Kestrel Therapeutics, Inc. as lead sponsor.

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Registry record

As filed in ClinicalTrials.gov.

Title
A First-in-human Phase 1 Dose-escalation Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of KST-6051 in Patients With Advanced or Metastatic Solid Tumors With a KRAS Mutation
Lead sponsor
Kestrel Therapeutics, Inc.
Phase
Phase 1
Overall status
Recruiting
Start date
April 21, 2026
Completion date
May 31, 2028
Enrollment
145 (estimated)
Sites
9

Conditions

As the registry lists them; a condition with its own page is linked.

kras-mutant colorectal cancer (crc), kras-mutant non-small cell lung cancer (nsclc), kras-mutant pancreatic ductal adenocarcinoma (pdac), other kras-mutant solid tumors