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Condition (MeSH)

Esophageal Squamous Cell Carcinoma

ClinicalTrials.gov lists 621 trials for Esophageal Squamous Cell Carcinoma or a narrower condition beneath it.

MeSH D000077277 Neoplasms Neoplasm C04 C06 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 72 Phase 1/2 Phase 1/2 40 Phase 2 Phase 2 297 Phase 2/3 Phase 2/3 15 Phase 3 Phase 3 64 Phase 4 Phase 4 2 Not applicable Not applicable 49 Observational Observational 82 Phase 1 Phase 1 72 Phase 1/2 Phase 1/2 40 Phase 2 Phase 2 297 Phase 2/3 Phase 2/3 15 Phase 3 Phase 3 64 Phase 4 Phase 4 2 Not applicable Not applicable 49 Observational Observational 82

Trials per phase (log scale)

621 of the 621 trials are tagged with Esophageal Squamous Cell Carcinoma itself; the rest are tagged with a narrower condition beneath it.

Get the Esophageal Squamous Cell Carcinoma report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Esophageal Squamous Cell Carcinoma trials start? (33)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 65

1992: 2 trials (Phase 3 1, Phase 2 1) 1994: 1 trials (Observational 1) 1995: 2 trials (Phase 3 1, Phase 1 1) 1996: 1 trials (Phase 3 1) 1997: 5 trials (Phase 3 1, Phase 2 3, Phase 1/2 1) 1999: 5 trials (Not applicable 2, Phase 2 2, Phase 1 1) 2000: 8 trials (Observational 1, Phase 3 1, Phase 2 5, Phase 1 1) 2001: 3 trials (Phase 2 3) 2002: 3 trials (Phase 3 1, Phase 2 2) 2003: 8 trials (Observational 2, Phase 2 3, Phase 1/2 2, Phase 1 1) 2004: 4 trials (Observational 1, Phase 2 3) 2005: 8 trials (Observational 1, Not applicable 1, Phase 2 5, Phase 1 1) 2006: 8 trials (Not applicable 1, Phase 2 5, Phase 1/2 1, Phase 1 1) 2007: 5 trials (Not applicable 1, Phase 3 1, Phase 1/2 2, Phase 1 1) 2008: 8 trials (Phase 3 1, Phase 2/3 2, Phase 2 4, Phase 1 1) 2009: 4 trials (Observational 2, Not applicable 1, Phase 3 1) 2010: 8 trials (Observational 1, Phase 3 2, Phase 2/3 1, Phase 2 4) 2011: 10 trials (Phase 3 1, Phase 2 8, Phase 1 1) 2012: 13 trials (Observational 3, Not applicable 2, Phase 3 3, Phase 2 4, Phase 1 1) 2013: 10 trials (Not applicable 2, Phase 2 5, Phase 1/2 1, Phase 1 2) 2014: 17 trials (Observational 2, Not applicable 1, Phase 3 6, Phase 2/3 1, Phase 2 6, Phase 1 1) 2015: 10 trials (Phase 3 3, Phase 2 7) 2016: 15 trials (Not applicable 1, Phase 3 1, Phase 2 8, Phase 1/2 2, Phase 1 3) 2017: 26 trials (Observational 2, Phase 3 1, Phase 2/3 1, Phase 2 18, Phase 1/2 3, Phase 1 1) 2018: 23 trials (Observational 4, Not applicable 3, Phase 3 6, Phase 2/3 1, Phase 2 7, Phase 1/2 1, Phase 1 1) 2019: 45 trials (Observational 6, Not applicable 3, Phase 3 5, Phase 2 22, Phase 1/2 1, Phase 1 8) 2020: 50 trials (Observational 7, Not applicable 6, Phase 3 5, Phase 2 23, Phase 1/2 1, Phase 1 8) 2021: 37 trials (Observational 5, Not applicable 5, Phase 3 2, Phase 2 18, Phase 1/2 3, Phase 1 4) 2022: 50 trials (Observational 5, Not applicable 6, Phase 4 1, Phase 3 5, Phase 2/3 2, Phase 2 24, Phase 1/2 4, Phase 1 3) 2023: 51 trials (Observational 8, Not applicable 4, Phase 3 3, Phase 2/3 1, Phase 2 21, Phase 1/2 6, Phase 1 8) 2024: 65 trials (Observational 7, Not applicable 6, Phase 4 1, Phase 3 5, Phase 2/3 2, Phase 2 36, Phase 1/2 1, Phase 1 7) 2025: 51 trials (Observational 9, Not applicable 1, Phase 3 3, Phase 2/3 2, Phase 2 19, Phase 1/2 6, Phase 1 11)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 65
2025 51
2024 65
2023 51
2022 50
2021 37
2020 50
2019 45
2018 23
2017 26

Forecast of the full-year count, planned starts included, not rows of this table: about 80 trials starting in 2026 and about 64 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 138 trials still running at the 2026-10-09 snapshot; registered median of 39 months across 225 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Esophageal Squamous Cell Carcinoma trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 72
Phase 1/2 40
Phase 2 297
Phase 2/3 15
Phase 3 64
Phase 4 2
Not applicable 49
Observational 82

How many Esophageal Squamous Cell Carcinoma trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 60
Recruiting 143
Enrolling by invitation 8
Active, not recruiting 41
Completed 169

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Esophageal Squamous Cell Carcinoma? (7)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
(nab)-paclitaxel 52
PEMBROLIZUMAB 31
Irinotecan 29
OXALIPLATIN 24
TORIPALIMAB 21

Interventions as named in the registry (8)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Cisplatin 1 73
Fluorouracile 49
Radiation Therapy 38
Radiotherapy 36
or carboplatin 26

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Esophageal Squamous Cell Carcinoma trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 267 15
Dysphagia 171 20
Neutrophil count decreased 112 11
Vomiting 99 19
Nausea 95 15

Which publications cover Esophageal Squamous Cell Carcinoma? (330)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Prevalence (28)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Squamous cell carcinoma of the esophagus Annual incidence 1-9 / 100 000 United Kingdom GB Unspecified
Squamous cell carcinoma of the esophagus Annual incidence 1-9 / 100 000 Malta Not stated Unspecified
Squamous cell carcinoma of the esophagus Annual incidence 1-9 / 100 000 Belgium Not stated Unspecified
Squamous cell carcinoma of the esophagus Annual incidence 1-9 / 100 000 Germany Not stated Unspecified
Squamous cell carcinoma of the esophagus Annual incidence 1-9 / 100 000 Slovakia Not stated Unspecified

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, rare-disease identity, and sub-conditions in mesh.

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