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Condition (MeSH)

Arrhythmia, Sinus

ClinicalTrials.gov lists 108 trials for Arrhythmia, Sinus or a narrower condition beneath it. Abbott Medical Devices has the most among industry and government lead sponsors, with 11.

MeSH D001146 Cardiovascular Diseases C14 C23
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Phase 2/3 Phase 2/3 2 Phase 3 Phase 3 4 Phase 4 Phase 4 12 Not applicable Not applicable 58 Observational Observational 32 Phase 2/3 Phase 2/3 2 Phase 3 Phase 3 4 Phase 4 Phase 4 12 Not applicable Not applicable 58 Observational Observational 32

Trials per phase (log scale)

18 of the 108 trials are tagged with Arrhythmia, Sinus itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Arrhythmia, Sinus trials start? (28)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 7

1990: 1 trials (Phase 3 1) 1995: 1 trials (Phase 3 1) 1999: 1 trials (Phase 2/3 1) 2000: 2 trials (Observational 1, Phase 4 1) 2003: 5 trials (Not applicable 2, Phase 4 3) 2004: 4 trials (Phase 4 4) 2005: 3 trials (Observational 1, Not applicable 1, Phase 4 1) 2006: 4 trials (Observational 3, Phase 4 1) 2007: 3 trials (Observational 1, Not applicable 1, Phase 4 1) 2008: 2 trials (Observational 1, Not applicable 1) 2009: 3 trials (Observational 2, Not applicable 1) 2010: 4 trials (Observational 1, Not applicable 3) 2011: 6 trials (Observational 3, Not applicable 3) 2012: 5 trials (Observational 3, Not applicable 2) 2013: 5 trials (Not applicable 5) 2014: 6 trials (Observational 2, Not applicable 3, Phase 3 1) 2015: 4 trials (Not applicable 3, Phase 4 1) 2016: 3 trials (Not applicable 2, Phase 3 1) 2017: 2 trials (Observational 1, Not applicable 1) 2018: 4 trials (Observational 3, Not applicable 1) 2019: 5 trials (Not applicable 5) 2020: 3 trials (Not applicable 3) 2021: 5 trials (Not applicable 4, Phase 2/3 1) 2022: 5 trials (Observational 1, Not applicable 4) 2023: 5 trials (Observational 3, Not applicable 2) 2024: 6 trials (Not applicable 6) 2025: 7 trials (Observational 4, Not applicable 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 4
2025 7
2024 6
2023 5
2022 5
2021 5
2020 3
2019 5
2018 4
2017 2

Forecast of the full-year count, planned starts included, not rows of this table: about 4 trials starting in 2026 and about 6 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored. The 2026 forecast is below the 4 already registered with a 2026 start date: at the cutoff, 2 trials were already registered to start in October to December, more than the method's monthly average allows for, and the method does not use those planned starts.

Prediction, not a registry value: median of 36 months from start to primary completion across 9 trials still running at the 2026-10-09 snapshot; registered median of 28 months across 58 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Arrhythmia, Sinus trials in? (5)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 2/3 2
Phase 3 4
Phase 4 12
Not applicable 58
Observational 32

How many Arrhythmia, Sinus trials are recruiting? (7)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 5
Recruiting 11
Enrolling by invitation 2
Completed 56
Terminated 10

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Arrhythmia, Sinus trials? (9)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Abbott Medical Devices 11
Medtronic Cardiac Rhythm and Heart Failure 7
Boston Scientific Corporation 5
Medtronic BRC 5
Biotronik SE & Co. KG 4

Which drugs are being tested for Arrhythmia, Sinus? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
NEBIVOLOL 1
Ivabradine 1
Atenolol 1

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Low dose losartan 1
Routine Management 1
polymixin/bacitracin 1
Focal Cryoablation 1
Pacemaker and defibrillator 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Arrhythmia, Sinus trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Non-cardiovascular 357 1
Cardiovascular - Non-Heart Failure 241 1
Cardiovascular - Heart Failure 101 1
Other 49 1
Cardiac Arrhythmia - Atrial Fibrillation 41 1

Which publications cover Arrhythmia, Sinus? (69)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Do you hear the same? Cardiorespiratory responses between mothers and infants during tonal and atonal music. PloS one 2014 Yes
Respiratory sinus arrhythmia and auditory processing in autism: modifiable deficits of an integrated social engagement system? International journal of psychophysiology : official journal of the International Organization of Psychophysiology 2013 Yes
Cardiac vagal control and children's adaptive functioning: a meta-analysis. Biological psychology 2013 Yes
Matters of the variable heart: respiratory sinus arrhythmia response to marital interaction and associations with marital quality. Journal of personality and social psychology 2011 Yes
Mapping cardiac physiology and parenting processes in maltreating mother-child dyads. Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) 2011 Yes

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages