Condition (MeSH)
Sick Sinus Syndrome
ClinicalTrials.gov lists 91 trials for Sick Sinus Syndrome or a narrower condition beneath it. Abbott Medical Devices has the most among industry and government lead sponsors, with 11.
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Trials per phase (log scale)
91 of the 91 trials are tagged with Sick Sinus Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Sick Sinus Syndrome trials start? (26)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 6
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 4 |
| 2025 | 6 |
| 2024 | 4 |
| 2023 | 4 |
| 2022 | 5 |
| 2021 | 3 |
| 2020 | 3 |
| 2019 | 3 |
| 2018 | 4 |
| 2016 | 2 |
Showing 10 of 26 earlier years.
No forecast is made for this condition: it averages 4.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 7 trials still running at the 2026-10-09 snapshot; registered median of 32 months across 48 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Sick Sinus Syndrome trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 2/3 | 2 |
| Phase 3 | 3 |
| Phase 4 | 11 |
| Not applicable | 46 |
| Observational | 29 |
How many Sick Sinus Syndrome trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 5 |
| Recruiting | 10 |
| Enrolling by invitation | 1 |
| Completed | 46 |
| Terminated | 9 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Sick Sinus Syndrome trials? (9)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Abbott Medical Devices | 11 |
| Medtronic Cardiac Rhythm and Heart Failure | 7 |
| Boston Scientific Corporation | 5 |
| Biotronik SE & Co. KG | 4 |
| Medtronic BRC | 4 |
Showing 5 of 9 sponsors.
Which drugs are being tested for Sick Sinus Syndrome? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| NEBIVOLOL | 1 |
| Ivabradine | 1 |
| Atenolol | 1 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Low dose losartan | 1 |
| Routine Management | 1 |
| polymixin/bacitracin | 1 |
| Focal Cryoablation | 1 |
| Pacemaker and defibrillator | 1 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Sick Sinus Syndrome trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Non-cardiovascular | 357 | 1 |
| Cardiovascular - Non-Heart Failure | 241 | 1 |
| Cardiovascular - Heart Failure | 101 | 1 |
| Other | 49 | 1 |
| Cardiac Arrhythmia - Atrial Fibrillation | 41 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Sick Sinus Syndrome? (91)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| One-Year Safety and Performance of a Dual-Chamber Leadless Pacemaker. | Circulation. Arrhythmia and electrophysiology | 2025 | Yes |
| Reliability, validity, and sensitivity of short-form 36 health survey (SF-36) in patients with sick sinus syndrome. | Medicine | 2023 | Yes |
| Atrial pacing minimization in sinus node dysfunction and risk of incident atrial fibrillation: a randomized trial. | European heart journal | 2023 | Yes |
| Durable Physiological Changes and Decreased Syncope Burden 12 Months After Unifocal Right-Sided Ablation Under Computed Tomographic Guidance in Patients With Neurally Mediated Syncope or Functional Sinus Node Dysfunction. | Circulation. Arrhythmia and electrophysiology | 2021 | Yes |
| Evaluation of cardiac synchrony in left bundle branch pacing: Insights from echocardiographic research. | Journal of cardiovascular electrophysiology | 2020 | Yes |
Showing 5 of 91 publications.
Prevalence (4)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Hereditary sick sinus syndrome | Cases families | Worldwide | Not stated | Exact | |
| Hereditary sick sinus syndrome | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Exact |
| Hereditary sick sinus syndrome | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Exact |
| Hereditary sick sinus syndrome | Cases families | Worldwide | Not stated | Exact |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Hereditary sick sinus syndrome | 166282 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Hereditary sick sinus syndrome | 166282 | Exact | Orphadata Science knowledge files, Product 1 |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.