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Condition (MeSH)

Gastrointestinal Neoplasms

ClinicalTrials.gov lists 14,385 trials for Gastrointestinal Neoplasms or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 316.

MeSH D005770 Neoplasms Neoplasm C04 C06
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Phase 1 Phase 1 1,571 Phase 1/2 Phase 1/2 898 Phase 2 Phase 2 3,326 Phase 2/3 Phase 2/3 203 Phase 3 Phase 3 1,121 Phase 4 Phase 4 254 Not applicable Not applicable 3,546 Observational Observational 3,435 Phase 1 Phase 1 1,571 Phase 1/2 Phase 1/2 898 Phase 2 Phase 2 3,326 Phase 2/3 Phase 2/3 203 Phase 3 Phase 3 1,121 Phase 4 Phase 4 254 Not applicable Not applicable 3,546 Observational Observational 3,435

Trials per phase

1 more section with rows

690 of the 14,385 trials are tagged with Gastrointestinal Neoplasms itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Gastrointestinal Neoplasms trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 18 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access)

Top of scale: 975

1990: 4 trials (Observational 2, Not applicable 1, Phase 3 1) 1991: 5 trials (Observational 2, Phase 3 2, Phase 2 1) 1992: 5 trials (Phase 3 2, Phase 2/3 1, Phase 2 1, Phase 1 1) 1993: 15 trials (Observational 3, Not applicable 1, Phase 3 10, Phase 2 1) 1994: 12 trials (Observational 3, Phase 3 6, Phase 2 2, Phase 1 1) 1995: 19 trials (Observational 2, Phase 3 6, Phase 2 5, Phase 1 6) 1996: 21 trials (Observational 3, Not applicable 1, Phase 3 5, Phase 2/3 1, Phase 2 10, Phase 1 1) 1997: 40 trials (Observational 3, Not applicable 3, Phase 3 10, Phase 2 11, Phase 1/2 7, Phase 1 6) 1998: 59 trials (Observational 11, Not applicable 3, Phase 4 1, Phase 3 10, Phase 2/3 1, Phase 2 19, Phase 1/2 2, Phase 1 12) 1999: 72 trials (Observational 10, Not applicable 7, Phase 3 12, Phase 2/3 1, Phase 2 24, Phase 1/2 5, Phase 1 13) 2000: 116 trials (Observational 18, Not applicable 6, Phase 3 19, Phase 2 43, Phase 1/2 12, Phase 1 18) 2001: 108 trials (Observational 7, Not applicable 2, Phase 4 1, Phase 3 20, Phase 2/3 1, Phase 2 49, Phase 1/2 8, Phase 1 20) 2002: 139 trials (Observational 26, Not applicable 8, Phase 4 4, Phase 3 25, Phase 2 53, Phase 1/2 9, Phase 1 14) 2003: 168 trials (Observational 29, Not applicable 13, Phase 4 3, Phase 3 30, Phase 2/3 2, Phase 2 58, Phase 1/2 12, Phase 1 21) 2004: 214 trials (Other 1, Observational 24, Not applicable 20, Phase 4 5, Phase 3 31, Phase 2/3 8, Phase 2 86, Phase 1/2 16, Phase 1 23) 2005: 244 trials (Observational 37, Not applicable 31, Phase 4 17, Phase 3 31, Phase 2/3 3, Phase 2 79, Phase 1/2 15, Phase 1 31) 2006: 296 trials (Observational 53, Not applicable 35, Phase 4 7, Phase 3 35, Phase 2/3 6, Phase 2 107, Phase 1/2 16, Phase 1 37) 2007: 330 trials (Observational 68, Not applicable 51, Phase 4 13, Phase 3 32, Phase 2/3 1, Phase 2 102, Phase 1/2 22, Phase 1 41) 2008: 350 trials (Observational 72, Not applicable 59, Phase 4 12, Phase 3 46, Phase 2/3 6, Phase 2 100, Phase 1/2 20, Phase 1 35) 2009: 382 trials (Observational 81, Not applicable 77, Phase 4 8, Phase 3 27, Phase 2/3 9, Phase 2 112, Phase 1/2 26, Phase 1 42) 2010: 419 trials (Observational 100, Not applicable 87, Phase 4 6, Phase 3 33, Phase 2/3 11, Phase 2 107, Phase 1/2 27, Phase 1 48) 2011: 441 trials (Observational 99, Not applicable 92, Phase 4 10, Phase 3 42, Phase 2/3 9, Phase 2 126, Phase 1/2 16, Phase 1 47) 2012: 469 trials (Observational 130, Not applicable 110, Phase 4 14, Phase 3 30, Phase 2/3 10, Phase 2 113, Phase 1/2 24, Phase 1 38) 2013: 455 trials (Observational 109, Not applicable 129, Phase 4 21, Phase 3 42, Phase 2/3 5, Phase 2 94, Phase 1/2 16, Phase 1 39) 2014: 490 trials (Observational 117, Not applicable 123, Phase 4 11, Phase 3 52, Phase 2/3 7, Phase 2 92, Phase 1/2 30, Phase 1 58) 2015: 555 trials (Observational 129, Not applicable 170, Phase 4 8, Phase 3 52, Phase 2/3 13, Phase 2 106, Phase 1/2 24, Phase 1 53) 2016: 598 trials (Observational 140, Not applicable 177, Phase 4 12, Phase 3 50, Phase 2/3 11, Phase 2 94, Phase 1/2 35, Phase 1 79) 2017: 666 trials (Observational 162, Not applicable 202, Phase 4 4, Phase 3 37, Phase 2/3 11, Phase 2 131, Phase 1/2 47, Phase 1 72) 2018: 685 trials (Observational 173, Not applicable 193, Phase 4 8, Phase 3 49, Phase 2/3 7, Phase 2 130, Phase 1/2 56, Phase 1 69) 2019: 713 trials (Observational 194, Not applicable 192, Phase 4 6, Phase 3 41, Phase 2/3 6, Phase 2 149, Phase 1/2 50, Phase 1 75) 2020: 798 trials (Observational 213, Not applicable 223, Phase 4 11, Phase 3 61, Phase 2/3 3, Phase 2 141, Phase 1/2 57, Phase 1 89) 2021: 861 trials (Observational 261, Not applicable 254, Phase 4 10, Phase 3 40, Phase 2/3 7, Phase 2 154, Phase 1/2 47, Phase 1 88) 2022: 902 trials (Observational 251, Not applicable 261, Phase 4 16, Phase 3 42, Phase 2/3 14, Phase 2 177, Phase 1/2 58, Phase 1 83) 2023: 942 trials (Observational 258, Not applicable 277, Phase 4 7, Phase 3 34, Phase 2/3 10, Phase 2 191, Phase 1/2 60, Phase 1 105) 2024: 975 trials (Observational 251, Not applicable 260, Phase 4 13, Phase 3 50, Phase 2/3 11, Phase 2 225, Phase 1/2 56, Phase 1 109) 2025: 896 trials (Observational 206, Not applicable 239, Phase 4 11, Phase 3 47, Phase 2/3 12, Phase 2 220, Phase 1/2 58, Phase 1 103)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 812
2025 896
2024 975
2023 942
2022 902
2021 861
2020 798
2019 713
2018 685
2017 666

Forecast of the full-year count, planned starts included, not rows of this table: about 1,000 trials starting in 2026 and about 920 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 10 percent and ran about 4 percent high against the count later registered; forecasts made before the year began were off by about 25 percent and ran about 15 percent low against the count later registered, and had about 7 percent more error than repeating last year's count. The part-way figures are from forecasts that used a multiple fitted only on earlier years. A stricter check that trains only on older years did not support adding planned starts for conditions of this size: it ran about 6 percent high against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 1,825 trials still running at the 2026-10-09 snapshot; registered median of 32 months across 7,290 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Gastrointestinal Neoplasms trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1,571
Phase 1/2 898
Phase 2 3,326
Phase 2/3 203
Phase 3 1,121
Phase 4 254
Not applicable 3,546
Observational 3,435
Expanded access 31

How many Gastrointestinal Neoplasms trials are recruiting? (12)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 807
Recruiting 2,249
Enrolling by invitation 106
Active, not recruiting 751
Available 11

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Gastrointestinal Neoplasms trials? (4)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 316
Hoffmann-La Roche 118
Pfizer 78
Novartis Pharmaceuticals 71

Which drugs are being tested for Gastrointestinal Neoplasms? (8)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
OXALIPLATIN 713
"Capecitabine" 559
Irinotecan 480
Calcium Leucovorin 413
CETUXIMAB 340

Interventions as named in the registry (7)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Fluorouracile 692
Bevacizumab 1 450
Cisplatin 1 271
Radiation Therapy 165
Docetetaxel 155

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Gastrointestinal Neoplasms trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Vomiting 2,996 499
Diarrhoea 2,762 308
Pneumonia 2,519 339
Abdominal pain 2,420 438
Malignant neoplasm progression 2,393 64

Which publications cover Gastrointestinal Neoplasms? (708)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages