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Condition (MeSH)

Intestinal Neoplasms

ClinicalTrials.gov lists 9,403 trials for Intestinal Neoplasms or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 216.

MeSH D007414 Neoplasms Neoplasm C04 C06
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Phase 1 Phase 1 1,102 Phase 1/2 Phase 1/2 593 Phase 2 Phase 2 1,898 Phase 2/3 Phase 2/3 123 Phase 3 Phase 3 680 Phase 4 Phase 4 159 Not applicable Not applicable 2,560 Observational Observational 2,272 Phase 1 Phase 1 1,102 Phase 1/2 Phase 1/2 593 Phase 2 Phase 2 1,898 Phase 2/3 Phase 2/3 123 Phase 3 Phase 3 680 Phase 4 Phase 4 159 Not applicable Not applicable 2,560 Observational Observational 2,272

Trials per phase (log scale)

1 more section with rows

100 of the 9,403 trials are tagged with Intestinal Neoplasms itself; the rest are tagged with a narrower condition beneath it.

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When did Intestinal Neoplasms trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 9 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 614

1990: 3 trials (Observational 1, Not applicable 1, Phase 3 1) 1991: 4 trials (Observational 1, Phase 3 2, Phase 2 1) 1992: 2 trials (Phase 3 1, Phase 2/3 1) 1993: 13 trials (Observational 3, Not applicable 1, Phase 3 8, Phase 2 1) 1994: 10 trials (Observational 2, Phase 3 5, Phase 2 2, Phase 1 1) 1995: 8 trials (Observational 1, Phase 3 1, Phase 2 3, Phase 1 3) 1996: 10 trials (Not applicable 1, Phase 3 3, Phase 2 5, Phase 1 1) 1997: 26 trials (Observational 1, Not applicable 3, Phase 3 8, Phase 2 4, Phase 1/2 5, Phase 1 5) 1998: 45 trials (Observational 8, Not applicable 3, Phase 4 1, Phase 3 10, Phase 2 10, Phase 1/2 2, Phase 1 11) 1999: 51 trials (Observational 7, Not applicable 5, Phase 3 10, Phase 2/3 1, Phase 2 16, Phase 1/2 3, Phase 1 9) 2000: 68 trials (Observational 9, Not applicable 4, Phase 3 14, Phase 2 19, Phase 1/2 10, Phase 1 12) 2001: 76 trials (Observational 4, Not applicable 1, Phase 3 15, Phase 2/3 1, Phase 2 33, Phase 1/2 7, Phase 1 15) 2002: 95 trials (Observational 18, Not applicable 7, Phase 4 4, Phase 3 13, Phase 2 34, Phase 1/2 6, Phase 1 13) 2003: 111 trials (Observational 20, Not applicable 12, Phase 4 2, Phase 3 21, Phase 2/3 2, Phase 2 31, Phase 1/2 6, Phase 1 17) 2004: 133 trials (Observational 16, Not applicable 15, Phase 4 2, Phase 3 19, Phase 2/3 8, Phase 2 49, Phase 1/2 11, Phase 1 13) 2005: 174 trials (Observational 25, Not applicable 29, Phase 4 15, Phase 3 22, Phase 2/3 3, Phase 2 47, Phase 1/2 9, Phase 1 24) 2006: 209 trials (Observational 44, Not applicable 23, Phase 4 4, Phase 3 28, Phase 2/3 5, Phase 2 66, Phase 1/2 12, Phase 1 27) 2007: 223 trials (Observational 46, Not applicable 42, Phase 4 10, Phase 3 23, Phase 2 59, Phase 1/2 14, Phase 1 29) 2008: 233 trials (Observational 53, Not applicable 48, Phase 4 8, Phase 3 29, Phase 2/3 2, Phase 2 57, Phase 1/2 14, Phase 1 22) 2009: 272 trials (Observational 63, Not applicable 56, Phase 4 6, Phase 3 12, Phase 2/3 5, Phase 2 78, Phase 1/2 19, Phase 1 33) 2010: 291 trials (Observational 63, Not applicable 71, Phase 4 4, Phase 3 24, Phase 2/3 7, Phase 2 68, Phase 1/2 21, Phase 1 33) 2011: 289 trials (Observational 69, Not applicable 70, Phase 4 6, Phase 3 24, Phase 2/3 6, Phase 2 67, Phase 1/2 10, Phase 1 37) 2012: 311 trials (Observational 93, Not applicable 79, Phase 4 10, Phase 3 14, Phase 2/3 4, Phase 2 66, Phase 1/2 20, Phase 1 25) 2013: 299 trials (Observational 68, Not applicable 99, Phase 4 11, Phase 3 23, Phase 2/3 2, Phase 2 58, Phase 1/2 9, Phase 1 29) 2014: 312 trials (Observational 78, Not applicable 82, Phase 4 5, Phase 3 29, Phase 2/3 4, Phase 2 60, Phase 1/2 18, Phase 1 36) 2015: 353 trials (Observational 87, Not applicable 126, Phase 4 4, Phase 3 24, Phase 2/3 7, Phase 2 60, Phase 1/2 13, Phase 1 32) 2016: 383 trials (Observational 90, Not applicable 120, Phase 4 5, Phase 3 30, Phase 2/3 6, Phase 2 53, Phase 1/2 24, Phase 1 55) 2017: 413 trials (Observational 103, Not applicable 148, Phase 4 3, Phase 3 15, Phase 2/3 7, Phase 2 60, Phase 1/2 29, Phase 1 48) 2018: 466 trials (Observational 130, Not applicable 134, Phase 4 5, Phase 3 25, Phase 2/3 5, Phase 2 84, Phase 1/2 36, Phase 1 47) 2019: 457 trials (Observational 127, Not applicable 133, Phase 4 5, Phase 3 22, Phase 2/3 4, Phase 2 80, Phase 1/2 33, Phase 1 53) 2020: 528 trials (Observational 154, Not applicable 156, Phase 4 6, Phase 3 35, Phase 2/3 3, Phase 2 74, Phase 1/2 38, Phase 1 62) 2021: 553 trials (Observational 179, Not applicable 176, Phase 4 5, Phase 3 24, Phase 2/3 5, Phase 2 73, Phase 1/2 31, Phase 1 60) 2022: 582 trials (Observational 172, Not applicable 183, Phase 4 7, Phase 3 24, Phase 2/3 7, Phase 2 102, Phase 1/2 34, Phase 1 53) 2023: 614 trials (Observational 152, Not applicable 201, Phase 4 7, Phase 3 23, Phase 2/3 7, Phase 2 114, Phase 1/2 37, Phase 1 73) 2024: 604 trials (Observational 152, Not applicable 175, Phase 4 7, Phase 3 34, Phase 2/3 6, Phase 2 106, Phase 1/2 37, Phase 1 87) 2025: 581 trials (Observational 115, Not applicable 179, Phase 4 9, Phase 3 30, Phase 2/3 6, Phase 2 136, Phase 1/2 35, Phase 1 71)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 533
2025 581
2024 604
2023 614
2022 582
2021 553
2020 528
2019 457
2018 466
2017 413

Forecast of the full-year count, planned starts included, not rows of this table: about 660 trials starting in 2026 and about 600 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 10 percent and ran about 4 percent high against the count later registered; forecasts made before the year began were off by about 25 percent and ran about 15 percent low against the count later registered, and had about 7 percent more error than repeating last year's count. The part-way figures are from forecasts that used a multiple fitted only on earlier years. A stricter check that trains only on older years did not support adding planned starts for conditions of this size: it ran about 6 percent high against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 1,176 trials still running at the 2026-10-09 snapshot; registered median of 32 months across 4,973 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Intestinal Neoplasms trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1,102
Phase 1/2 593
Phase 2 1,898
Phase 2/3 123
Phase 3 680
Phase 4 159
Not applicable 2,560
Observational 2,272
Expanded access 16

How many Intestinal Neoplasms trials are recruiting? (12)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 499
Recruiting 1,428
Enrolling by invitation 68
Active, not recruiting 509
Available 6

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Intestinal Neoplasms trials? (5)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 216
Hoffmann-La Roche 87
Pfizer 53
Eli Lilly and Company 45
Amgen 42

Which drugs are being tested for Intestinal Neoplasms? (8)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
OXALIPLATIN 463
"Capecitabine" 380
Irinotecan 366
Calcium Leucovorin 327
CETUXIMAB 312

Interventions as named in the registry (7)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Fluorouracile 482
Bevacizumab 1 425
Regorafenib Pill 104
Radiation Therapy 84
AG chemotherapy 81

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Intestinal Neoplasms trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Diarrhoea 1,927 206
Vomiting 1,471 302
Abdominal pain 1,406 280
Pyrexia 1,329 210
Dehydration 1,323 270

Which publications cover Intestinal Neoplasms? (159)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (3)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages