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Condition (MeSH)

Jaw Abnormalities

ClinicalTrials.gov lists 214 trials for Jaw Abnormalities or a narrower condition beneath it.

MeSH D007569 Musculoskeletal Diseases C05 C07 C16
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Phase 1 Phase 1 3 Phase 1/2 Phase 1/2 5 Phase 2 Phase 2 7 Phase 2/3 Phase 2/3 2 Phase 3 Phase 3 9 Phase 4 Phase 4 6 Not applicable Not applicable 121 Observational Observational 61 Phase 1 Phase 1 3 Phase 1/2 Phase 1/2 5 Phase 2 Phase 2 7 Phase 2/3 Phase 2/3 2 Phase 3 Phase 3 9 Phase 4 Phase 4 6 Not applicable Not applicable 121 Observational Observational 61

Trials per phase (log scale)

10 of the 214 trials are tagged with Jaw Abnormalities itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Jaw Abnormalities trials start? (27)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 22

1995: 1 trials (Observational 1) 1996: 1 trials (Phase 2 1) 1998: 1 trials (Observational 1) 2002: 1 trials (Phase 2 1) 2003: 1 trials (Not applicable 1) 2004: 1 trials (Phase 3 1) 2006: 5 trials (Observational 2, Not applicable 1, Phase 3 2) 2007: 4 trials (Observational 2, Phase 3 1, Phase 1 1) 2008: 3 trials (Not applicable 2, Phase 2 1) 2009: 4 trials (Observational 2, Not applicable 1, Phase 3 1) 2010: 5 trials (Observational 3, Not applicable 2) 2011: 4 trials (Observational 2, Not applicable 1, Phase 2 1) 2012: 6 trials (Observational 2, Not applicable 3, Phase 1/2 1) 2013: 6 trials (Observational 1, Not applicable 3, Phase 4 1, Phase 1/2 1) 2014: 6 trials (Observational 3, Not applicable 3) 2015: 10 trials (Observational 2, Not applicable 5, Phase 2 1, Phase 1/2 2) 2016: 13 trials (Observational 6, Not applicable 5, Phase 3 1, Phase 2/3 1) 2017: 5 trials (Observational 2, Not applicable 2, Phase 4 1) 2018: 16 trials (Observational 6, Not applicable 8, Phase 4 1, Phase 2 1) 2019: 16 trials (Observational 3, Not applicable 12, Phase 4 1) 2020: 15 trials (Observational 7, Not applicable 7, Phase 2 1) 2021: 11 trials (Observational 2, Not applicable 7, Phase 3 2) 2022: 13 trials (Observational 2, Not applicable 9, Phase 2/3 1, Phase 1 1) 2023: 14 trials (Observational 1, Not applicable 13) 2024: 22 trials (Observational 2, Not applicable 16, Phase 4 1, Phase 3 1, Phase 1/2 1, Phase 1 1) 2025: 22 trials (Observational 8, Not applicable 13, Phase 4 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 8
2025 22
2024 22
2023 14
2022 13
2021 11
2020 15
2019 16
2018 16
2017 5

Forecast of the full-year count, planned starts included, not rows of this table: about 12 trials starting in 2026 and about 17 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 23 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 113 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Jaw Abnormalities trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 3
Phase 1/2 5
Phase 2 7
Phase 2/3 2
Phase 3 9
Phase 4 6
Not applicable 121
Observational 61

How many Jaw Abnormalities trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 14
Recruiting 26
Enrolling by invitation 6
Active, not recruiting 6
Completed 106

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Jaw Abnormalities? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
+/- Bupivacaine HCl 5
DEXMEDETOMIDINE 4

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
A3: Acetaminophen (Tylenol caplets®, from Janssen-Cilag, S.A. de C.V.) 3
systematic therapy 2
acid tranexamic 2
computerized tomography 1
Ropivacaine 2 % 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Jaw Abnormalities trials report? (6)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
metabolism 3 1
Car accident 1 1
Poor feeding 1 1
Upper airway infection 1 1
Upper airway obstructive features 1 1

Which publications cover Jaw Abnormalities? (15)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Two-stage treatment protocol for management of temporomandibular joint ankylosis with secondary deformities in adults: our institution's experience. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2011 Yes
Incidence of complications and problems related to orthognathic surgery. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2007 Yes
A modified approach to "model planning" in orthognathic surgery for patients without a reliable centric relation. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2006 Yes
Sleep-disordered breathing and upper-airway anomalies in first-degree relatives of ALTE children. Pediatric research 2001 Yes
An adjustable bone fixation system for sagittal split ramus osteotomy: preliminary report. The British journal of oral & maxillofacial surgery 1999 Yes

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.

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