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Condition (MeSH)

Neoplasms, Mesothelial

ClinicalTrials.gov lists 561 trials for Neoplasms, Mesothelial or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 51.

MeSH D018301 Neoplasms Neoplasm C04
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Phase 1 Phase 1 160 Phase 1/2 Phase 1/2 76 Phase 2 Phase 2 169 Phase 2/3 Phase 2/3 5 Phase 3 Phase 3 21 Phase 4 Phase 4 5 Not applicable Not applicable 44 Observational Observational 79 Phase 1 Phase 1 160 Phase 1/2 Phase 1/2 76 Phase 2 Phase 2 169 Phase 2/3 Phase 2/3 5 Phase 3 Phase 3 21 Phase 4 Phase 4 5 Not applicable Not applicable 44 Observational Observational 79

Trials per phase (log scale)

1 more section with rows

2 of the 561 trials are tagged with Neoplasms, Mesothelial itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Neoplasms, Mesothelial trials start? (34)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 38

1991: 1 trials (Phase 2 1) 1992: 1 trials (Observational 1) 1994: 1 trials (Phase 2 1) 1996: 2 trials (Phase 2 1, Phase 1 1) 1997: 4 trials (Phase 3 1, Phase 1 3) 1998: 2 trials (Phase 3 1, Phase 2 1) 1999: 7 trials (Phase 3 2, Phase 2 3, Phase 1 2) 2000: 8 trials (Phase 2 6, Phase 1 2) 2001: 10 trials (Not applicable 1, Phase 3 1, Phase 2 6, Phase 1 2) 2002: 6 trials (Observational 1, Phase 2 4, Phase 1 1) 2003: 8 trials (Phase 3 2, Phase 2 3, Phase 1 3) 2004: 8 trials (Observational 1, Phase 2 6, Phase 1 1) 2005: 10 trials (Observational 3, Not applicable 1, Phase 3 1, Phase 2 4, Phase 1 1) 2006: 21 trials (Not applicable 2, Phase 2 10, Phase 1/2 1, Phase 1 8) 2007: 22 trials (Observational 4, Phase 3 1, Phase 2 9, Phase 1/2 1, Phase 1 7) 2008: 18 trials (Observational 2, Not applicable 2, Phase 2/3 1, Phase 2 8, Phase 1/2 3, Phase 1 2) 2009: 14 trials (Observational 5, Phase 2 6, Phase 1/2 1, Phase 1 2) 2010: 15 trials (Observational 1, Not applicable 2, Phase 3 1, Phase 2 5, Phase 1/2 2, Phase 1 4) 2011: 15 trials (Observational 4, Not applicable 3, Phase 2 2, Phase 1/2 2, Phase 1 4) 2012: 16 trials (Observational 3, Not applicable 2, Phase 3 1, Phase 2 4, Phase 1/2 3, Phase 1 3) 2013: 17 trials (Observational 6, Phase 2/3 1, Phase 2 6, Phase 1/2 2, Phase 1 2) 2014: 10 trials (Observational 2, Not applicable 2, Phase 2 3, Phase 1 3) 2015: 34 trials (Observational 4, Not applicable 3, Phase 3 2, Phase 2 11, Phase 1/2 5, Phase 1 9) 2016: 34 trials (Observational 6, Not applicable 1, Phase 3 1, Phase 2/3 1, Phase 2 11, Phase 1/2 4, Phase 1 10) 2017: 25 trials (Observational 1, Not applicable 2, Phase 3 1, Phase 2/3 1, Phase 2 6, Phase 1/2 10, Phase 1 4) 2018: 25 trials (Observational 2, Not applicable 2, Phase 2/3 1, Phase 2 6, Phase 1/2 5, Phase 1 9) 2019: 38 trials (Observational 5, Not applicable 2, Phase 4 3, Phase 3 1, Phase 2 6, Phase 1/2 5, Phase 1 16) 2020: 26 trials (Observational 4, Not applicable 2, Phase 4 1, Phase 3 1, Phase 2 4, Phase 1/2 1, Phase 1 13) 2021: 32 trials (Observational 5, Not applicable 3, Phase 3 2, Phase 2 8, Phase 1/2 3, Phase 1 11) 2022: 31 trials (Observational 5, Not applicable 2, Phase 2 7, Phase 1/2 7, Phase 1 10) 2023: 31 trials (Observational 5, Not applicable 4, Phase 4 1, Phase 3 1, Phase 2 6, Phase 1/2 7, Phase 1 7) 2024: 32 trials (Observational 5, Not applicable 5, Phase 2 7, Phase 1/2 4, Phase 1 11) 2025: 16 trials (Observational 3, Not applicable 2, Phase 2 4, Phase 1/2 4, Phase 1 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 17
2025 16
2024 32
2023 31
2022 31
2021 32
2020 26
2019 38
2018 25
2017 25

Forecast of the full-year count, planned starts included, not rows of this table: about 21 trials starting in 2026 and about 18 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 74 trials still running at the 2026-10-09 snapshot; registered median of 41 months across 350 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Neoplasms, Mesothelial trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 160
Phase 1/2 76
Phase 2 169
Phase 2/3 5
Phase 3 21
Phase 4 5
Not applicable 44
Observational 79
Expanded access 2

How many Neoplasms, Mesothelial trials are recruiting? (11)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 13
Recruiting 75
Enrolling by invitation 3
Active, not recruiting 35
Completed 249

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Neoplasms, Mesothelial trials? (6)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 51
Eli Lilly and Company 7
European Organisation for Research and Treatment of Cancer - EORTC 7
Novartis Pharmaceuticals 7
Bayer 5

Which drugs are being tested for Neoplasms, Mesothelial? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
PEMBROLIZUMAB 33
NIVOLUMAB 22
Cytoxan 15
IPILIMUMAB 11

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Cisplatin 1 55
Pemetrexe 40
Gemcitabine/Gemzar 18
Pemetrexed Disodium Injection 11
or carboplatin 10

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Neoplasms, Mesothelial trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Dyspnoea 226 24
Malignant neoplasm progression 189 8
Pneumonia 177 31
Pyrexia 144 24
Anaemia 139 21

Which publications cover Neoplasms, Mesothelial? (1)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Chemoimmunotherapy: an emerging strategy for the treatment of malignant mesothelioma. Tissue antigens 2009 Yes

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages