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Condition (MeSH)

Central Nervous System Protozoal Infections

ClinicalTrials.gov lists 33 trials for Central Nervous System Protozoal Infections or a narrower condition beneath it. National Institute of Allergy and Infectious Diseases (NIAID) has the most among industry and government lead sponsors, with 5.

MeSH D020808 Infections C01 C10
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Phase 1 Phase 1 4 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 5 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 6 Not applicable Not applicable 8 Observational Observational 6 Unknown Unknown 1 Phase 1 Phase 1 4 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 5 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 6 Not applicable Not applicable 8 Observational Observational 6 Unknown Unknown 1

Trials per phase

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When did Central Nervous System Protozoal Infections trials start? (18)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Not applicable
  • Observational
  • Unknown

Top of scale: 2

2003: 1 trials (Phase 3 1) 2004: 1 trials (Phase 3 1) 2006: 1 trials (Phase 1 1) 2007: 2 trials (Observational 1, Phase 2/3 1) 2008: 1 trials (Not applicable 1) 2009: 1 trials (Observational 1) 2010: 2 trials (Phase 3 2) 2011: 1 trials (Phase 2 1) 2012: 1 trials (Phase 3 1) 2013: 1 trials (Phase 1/2 1) 2014: 1 trials (Phase 2 1) 2016: 1 trials (Not applicable 1) 2018: 2 trials (Not applicable 1, Phase 3 1) 2021: 2 trials (Not applicable 1, Phase 2 1) 2022: 2 trials (Unknown 1, Phase 1/2 1) 2023: 1 trials (Observational 1) 2024: 1 trials (Observational 1) 2025: 1 trials (Observational 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2025 1
2024 1
2023 1
2022 2
2021 2
2018 2
2016 1
2014 1
2013 1
2012 1

No forecast is made for this condition: it averages 1.2 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Central Nervous System Protozoal Infections trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 4
Phase 1/2 2
Phase 2 5
Phase 2/3 1
Phase 3 6
Not applicable 8
Observational 6
Unknown 1

How many Central Nervous System Protozoal Infections trials are recruiting? (4)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Recruiting 2
Completed 25
Terminated 1
Unknown status 5

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Central Nervous System Protozoal Infections trials? (3)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Institute of Allergy and Infectious Diseases (NIAID) 5
U.S. Army Medical Research and Development Command 2
Glaxo Wellcome 1

Which drugs are being tested for Central Nervous System Protozoal Infections? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Pyrimethamine 7
Calcium Leucovorin 5
Atovaquone 2

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Intravenous Artesunate 2
Levetiracetam XR 2
Clindamycin Gel 2
1% Azithromycin 1
20% mannitol 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Central Nervous System Protozoal Infections trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
death 6 1
elevated AST 5 1
Sepsis 4 1
Respiratory problems from ventilator 3 1
respiratory suppression or aspiration 3 1

Sub-conditions in MeSH (3)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: publications, prevalence, and rare-disease identity.

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